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Medicinski časopis
2016, vol. 50, br. 4, str. 144-149
jezik rada: engleski
vrsta rada: prikaz
doi:10.5937/mckg50-13270


Mali disajni putevi u astmi
aClinic of Pulmonology, Clinical Centre 'Kragujevac ', Kragujevac
bClinic of Pulmonology, Clinical Centre 'Kragujevac ', Kragujevac + Faculty of Medical Sciences, University of Kragujevac, Kragujevac

e-adresa: icekerevac@gmail.com

Sažetak

Astma je hronična inflamatorna bolest pluća koju karakterišu hiperreaktivnost bronhijalnog stabla i reverzibilna opstrukcija disajnih puteva. Poslednjih godina pažnja se fokusira na ulogu malih disajnih puteva u astmi i nađeni su mnogobrojni dokazi o njihovom značajnom uticaju na kliničke manifestacije bolesti. Brojne studije su pokazale da postoji inflamacija u malim disajnim putevima i da je intenzivnija od one u većim disajnim putevima, posebno kod bolesnika sa teškom astmom, noćnom astmom, kod gojaznih pacijenata i pušača. Trenutno ne postoji prihvaćena pojedinačna dijagnostička metoda za preciznu procenu disfunkcije malih disajnih puteva. Najnoviji podaci pokazuju da je impulsna oscilometrija dijagnostička metoda koja mnogo obećava u proceni malih disajnih puteva u astmi. Upotreba kortikosteroida u formi ekstrafinih čestica, bilo posebno bilo u fiksnoj kombinaciji sa dugodelujućim beta 2 agonistima, poboljšava distribuciju leka kroz bronhijalno stablo, a time se nižim dozama leka postiže bolji terapijski učinak.

Ključne reči

astma; bronhiole; zapaljenje

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