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Advanced Technologies
2015, vol. 4, br. 2, str. 5-10
jezik rada: engleski
vrsta rada: izvorni naučni članak
doi:10.5937/savteh1502005B


Antimikrobna aktivnost ekstrakata origana (Origanum vulgare L.) i bosiljka (Ocimum basilicum L.)
aUniverzitet u Beogradu, Farmaceutski fakultet
bUniverzitet u Beogradu, Farmaceutski fakultet, Institut za mikrobiologiju i imunologiju
cUniverzitet u Beogradu, Institut za molekularnu genetiku i genetičko inženjerstvo, Beograd

e-adresa: ktatjana@pharmacy.bg.ac.rs

Projekat

Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (MPNTR - 173021)
Biljni i sinteticki bioaktivni proizvodi novije generacije (MPNTR - 34012)

Sažetak

Komercijalni uzorci nadzemnih delova Origanum vulgare L. i Ocimum basilicum L. (Lamiaceae) su korišćeni za određivanje antimikrobne aktivnosti. Aktivnost ekstrakata različite polarnosti je testirana protiv izabranih mikroorganizama, uključujući laboratorijski soj Helicobacter pilori NCTC 12868. Testirani ekstrakti su imali umerenu aktivnost. Ekstrakti O. vulgare su bili aktivniji protiv bakterija, posebno Gram pozitivnih bakterija sa minimalnim inhibitornim koncentracijama (MIK) između 62,5 i 125 μg/mL, od ekstrakata O. basilicum koji su pokazali aktivnost protiv Candida albicans (MIK 125 μg/mL). Cikloheksanski ekstrakt O. vulgare nije pokazao antimikrobnu aktivnost na testirani H. pylori, dok su ostali testirani ekstrakti bili aktivni sa MIK vrednostima između 250 μg/mL i 500 μg/mL. Identifikovana i kvantifikovana ruzmarinska kiselina i druga polarna jedinjenja mogu predstavljati aktivna jedinjenja sa antibakterijskom aktivnošću u ovim začinima.

Ključne reči

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