članak: 1 od 1  
Medicinski pregled
2005, vol. 58, br. 1-2, str. 5-10
jezik rada: srpski
članak
doi:10.2298/MPNS0502005N

Skrining hromozomopatija - akcenat na prvom trimestru
Klinički centar Novi Sad

Sažetak

U savremenoj perinatologiji skriningu hromozomopatija posvećuje se velika pažnja i postojeće metode se stalno unapređuju. Bez obzira koji test koristili, treba biti samokritičan - ultrazvučni pregled u prvom trimestru je veoma važan ne samo zbog markera hromozomopatija, nego i isključivanja postojanja velikih defekata fetusa, te je potrebno napraviti detaljan pregled. Merenje nuhalne translucencije je jedan od najvažnijih koraka ovog procesa, i preporučuje se da svi operateri koji pristupaju proceni rizika od hromozomopatija prođu adekvatnu obuku i sertifikaciju Fondacije za fetalnu medicinu, radi postizanja adekvatnog nivoa pregleda i reproducibilnosti rezultata. Laboratorije koje se bave biohemijskim skriningom i u prvom i u drugom trimestru moraju biti sertifikovane za to, te imati stalnu spoljnu kontrolu kvaliteta rezultata, jer je u protivnom više kako lažno pozitivnih, tako i lažno negativnih nalaza, što smanjuje stopu detekcije. Veoma je važno da se pacijentima uvek napomene i to da se radi o procesu skrininga, ma koliko efikasan on bio, a ne definitivne dijagnoze i da se dijagnoza može postaviti samo na osnovu invazivne intervencije i određivanja kariotipa ploda.

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