Metrika članka

  • citati u SCindeksu: [1]
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[=>]
  • posete u poslednjih 30 dana:2
  • preuzimanja u poslednjih 30 dana:0
članak: 1 od 1  
Medicinski pregled
2012, vol. 65, br. 1-2, str. 9-12
jezik rada: engleski
vrsta rada: izvorni naučni članak
doi:10.2298/MPNS1202009V


Hemoragijske komplikacije trombolitičke terapije
Clinical Center Banjaluka, Department of Neurology, Banja Luka, Republika Srpska, Bosnia and Herzegovina

e-adresa: vujkoviczoran@gmail.com

Sažetak

Uvod. Moždani udar je najčešći neurološki poremećaj i najčešći uzrok značajne nesposobnosti u poređenju s drugim bolestima. Rekombinantni tkivni aktivator plazminogena dokazana je specifična terapija za akutni ishemijski moždani udar. Hemoragija je značajna komplikacija trombolitičkog tretmana. Materijal i metode. U radu su ispitivane komplikacije nakon 100 trombolitičkih tretmana kod moždanog udara. Sve trombolitičke terapije date su u periodu od 30. marta 2007. do 2. maja 2011. Imali smo 100 pacijenata (52 muškarca, 48 žena). Rezultati. Smrt uzrokovana krvarenjem nakon trombolize bila je 3%, a ukupna smrtnost 6%. Učestalost svih hemoragičnih događaja bila je 16%. Učestalost simptomatske intracerebalne hemoragije u ovoj studiji (5%) slična je onoj koja je registrovana u studiji National Institute of Neurological Disorders and Stroke (6,4%). Zaključak. Rezultati studije pokazali su da je intravenska rekombinantnim tkivnim aktivatorom plazminogena terapija sigurna. Smrtnost uzrokovana krvarenjem nakon trombolize bila je mala (3%).

Ključne reči

Reference

Blinzler, C., Breuer, L., Huttner, H.B., Schellinger, P.D., Schwab, S., Köhrmann, M. (2011) Characteristics and outcome of patients with early complete neurological recovery after thrombolysis for acute ischemic stroke. Cerebrovascular diseases (Basel, Switzerland), 31(2): 185-90
Carpenter, C.R., Keim, S.M., Milne, W.K., Meurer, W.J., Barsan, W.G. (2011) Thrombolytic therapy for acute ischemic stroke beyond three hours. Journal of emergency medicine, 40(1): 82-92
Derex, L., Nighoghossian, N. (2008) Intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: An update. Journal of neurology, neurosurgery, and psychiatry, 79(10): 1093-9
Dowlatshahi, D., Demchuk, A.M., Flaherty, M.L., Ali, M., Lyden, P.L., Smith, E.E. (2011) Defining hematoma expansion in intracerebral hemorrhage: Relationship with patient outcomes. Neurology, 76(14): 1238-44
Fugate, J.E., Giraldo, E.A., Rabinstein, A.A. (2010) Thrombolysis for Cerebral IschemiaFront Neurol. 1: 139
Hacke, W., Kaste, M., Fieschi, C., von Kummer, R., Davalos, A., Meier, D., Larrue, V., Bluhmki, E., Davis, S., Donnan, G., Schneider, D., Diez-Tejedor, E., Trouillas, P. (1998) Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet, 352(9136): 1245-51
Kim, Y.D., Lee, J.H., Jung, Y.H., Choi, H.Y., Nam, C.M., Yang, J.H., Cho, H.J., Nam, H.S., Lee, K., Heo, J.H. (2010) Safety and outcome after thrombolytic treatment in ischemic stroke patients with high-risk cardioembolic sources and prior subtherapeutic warfarin use. Journal of the neurological sciences, 298(1-2): 101-5
Lee, S.J., Saver, J.L., Liebeskind, D.S., Ali, L., Ovbiagele, B., Kim, D., Vespa, P., Froehler, M., Tenser, M., Gadhia, J., Starkman, S. (2010) Safety of intravenous fibrinolysis in imaging-confirmed single penetrator artery infarcts. Stroke, 41(11): 2587-91
Marler, J.R., Tilley, B.C., Lu, M., Brott, T.G., Lyden, P.C., Grotta, J.C., Broderick, J.P., Levine, S.R., Frankel, M.P., Horowitz, S.H., Haley, E.C., Lewandowski, C.A., Kwiatkowski, T.P. (2000) Early stroke treatment associated with better outcome: The NINDS rt-PA stroke study. Neurology, 55(11): 1649-55
Martínez-Hernández, E., Martínez-Ramírez, S., Delgado-Mederos, R., Alcolea, D., Marquié, M., Marín, R., de Juan, M., Martí-Vilalta, J.L., Martí-Fàbregas, J. (2010) Remote cerebral hematomas in patients treated with intravenous rt-PA. Journal of neurology, 257(7): 1062-6
Perini, F., de Boni, A., Marcon, M., Bolgan, I., Pellizzari, M., Dionisio, L.D. (2010) Systolic blood pressure contributes to intracerebral haemorrhage after thrombolysis for ischemic stroke. Journal of the neurological sciences, 297(1-2): 52-4
Slankamenac, P., Miljković, S. (2007) Cerebrovaskularne bolesti. u: Pajić D. i dr. [ur.] Hirurgija, Novi Sad: Symbol
Slankamenac, P., Stefanović, D., Žikić, M. (2007) Neurologija danas. Medicinski pregled, vol. 60, br. 11-12, str. 629-635
Slankamenac, P., Jesic, A., Zivanovic, Z., Gebauer-Bukurov, K., Bozic, K. (2010) Agenesis of internal carotid artery with unusual fetal collateral circulation. Archives of neurology, 67(10): 1280-1
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med, 333(24): 1581-7
The NINDS t-PA Stroke Study Group (1997) Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. Stroke, 28(11): 2109-18
Vujkovic, Z., Slankamenac, P. (2010) Color duplex ultrasonography in neurology. u: Stankovic S., Slankamenac P. [ur.] Diagnostic ultrasound, Novi Sad: Medical faculty, p. 179-224