članak: 1 od 1  
Vojnosanitetski pregled
2002, vol. 59, br. 3, str. 265-270
jezik rada: engleski
stručni članak
doi:10.2298/VSP0203265T

Intratekalna sinteza komponenti komplementa C3c i C4 u infekcijama centralnog nervnog sistema koje se manifestuju sindromom akutnog seroznog meningitisa
Vojnomedicinska akademija

Sažetak

Kod 210 bolesnika s meningizmom i infekcijama centralnog nervnog sistema koje se manifestuju sindromom akutnog seroznog meningitisa (ASM), podeljenih u grupe na temelju etiologije (enterovirusni meningitis-ENTERO, serozni meningitis različite etiologije-SM i tuberkulozni meningitis-TBC) određena je intratekalna sinteza (ITS) komponenti komplementa C3c i C4 (kao i IgG) metodom likvorskih indeksa (I), da bi se istražila njihova uloga u diferencijalnoj dijagnozi ovoga sindroma. Urađena je korelativna studija između albuminskih kvocijenata (QAlb) i QC3c i QC4 kod bolesnika kod kojih nije dokazana ITS ova dva proteina komplementa, kao i komparativna studija povišenih vrednosti C3cI i C4I (kao i IgGI) između ispitivanih grupa bolesnika. Nađena je statistički visoko značajna korelacija između QAlb i QC3c (r = 0,89, p<0,001) i QC4 (r = 0,85, p<0,001). ITS C3c i C4 nađena je ukupno u 22,4% ispitivanih bolesnika. Nije nađena razlika u učestalosti ITS ova dva proteina komplementa između ispitivanih grupa, niti unutar pojedine grupe. Nađen je statistički značajno niži intenzitet ITS C3c i C4 u TBC grupi (p<0,05) i to u odnosu na ENTERO i SM za C3c, na MNG i ENTERO za C4, a značajno viši intenzitet ITS IgG (p<0,05) u odnosu na ostale ispitivane grupe. Likvorski indeks je veoma dobra metoda za detekciju ITS C3c i C4. Određivanje ITS C3c i C4 ne može biti od veće pomoći u diferencijalnoj dijagnozi bolesnika sa sindromom ASM. Intenzitet ITS C3c i C4, ukoliko se stavi u odnos sa intenzitetom ITS IgG, možda bi mogao govoriti o fazi bolesti.

Ključne reči

meningitis; meningizam; cerebrospinalna tečnost; cerebrospinalna tečnost, proteini; komplementi; IGG; dijagnoza, diferencijalna

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