Impulse oscillometry in evaluation bronchial hyperresponsiveness in patients with persistent allergic rhinitis

Koruga, Dragan; Baletić, Nenad; Tot-Vereš, Kristina; Perić, Aleksandar

doi:10.2298/VSP160407236K

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Vojnosanitetski pregled

2018, vol. 75, br. 1, str. 39-45

Impulsna oscilometrija u proceni bronhijalne hipereaktivnosti kod bolesnika sa perzistentnim alergijskim rinitisom

Koruga Dragan^a, Baletić Nenad^b, Tot-Vereš Kristina^a, Perić Aleksandar^b

^aMilitary Medical Centre, Department of Pulmonary Diseases, Novi Sad
^bVojnomedicinska akademija, Klinika za otorinolaringologiju, Beograd + Univerzitet odbrane, Medicinski fakultet Vojnomedicinske akademije, Beograd

e-adresa: dkoruga16@gmail.com

Ključne reči: rinitis; alergijski; oscilometrija; spirometrija; respiratorna funkcija; testovi; dijagnoza; osetljivost i specifičnost

Sažetak

Uvod/Cilj. Impulsna oscilometrija (IOS) je metod za procenu funkcije pluća koji se koristi za rano otkrivanje bronhijalne hiperreaktivnosti (BHR) i astme. Cilj rada je bio da se utvrde učestalost BHR, korelacija između IOS i spirometrije, senzitivnost i specifičnost IOS u dijagnozi BHR kod bolesnika sa perzistentnim alergijskim rinitisom. Metode. Od 81 ispitanika sa alergijskim rinitisom uzeta je anamneza, urađeno je alergološko testiranje, merenja funkcije pluća pomoću spirometrije i IOS pre i posle nespecifičnog bronhoprovokativnog testa (BPT) sa histaminom preko Aerosol provokacionog sistema. Merene su promene parametara IOS do pada FEV1 za 20% koje su upoređivane sa promenama spirometrijskih parametara. Nakon BPT ispitanici su bili podeljeni u grupu sa BHR (grupa 1) i bez BHR (grupa 2). Rezultati. Prosečno životno doba ispitanika iznosilo je 25,7 ± 5,7 godina, a 50,5% su bili muškarci. Od ukupnog broja ispitanika sa alergijskim rinitisom 56 (58,9%) su imali pozitivan BPT. Posle bronhoprovokacije u grupi 1 prosečno povećanje za Rrs5 bilo je 88,15%, za Fres 111,98%, za AX 819,69%. Visok stepen korelacije dokazan je između IOS i spirometrije u grupi 2, dok je u grupi 1 utvrđena slaba korelacija između vrednosti parametara ova dva metoda. Dokazana je visoka senzitivnost i niska specifičnost za vrednosti Rrs5 i Fres u odnosu na FEV1 u dijagnostikovanju BHR. Zaključak. Dokazana je visoka prevalencija BHR u grupi pacijenata sa perzistentnim alergijskim rinitisom, loša korelacija u odnosu na spirometrijska merenja u grupi sa BHR i visoka osetljivost i niska specifičnost IOS u detekciji ranih promena u disajnim putevima.

Abstract

Background/Aim. Impulse oscillometry (IOS) is a method for estimating lung function which is used for early detection of bronchial hyperresponsiveness (BHR) and asthma. The aim of the study was to determine the prevalence of BHR, the correlation between spirometry and IOS and sensitivity and specificity of IOS in proving BHR in patients with persistent allergic rhinitis. Methods. The study included 81 patients with allergic rhinitis. From all of them, medical history was taken, allergy testing was done, as well as measurements of parameters of lung function by the IOS and spirometry before and after nonspecific bronchial provocation test with histamin via Aerosol provocative system. Changes of the IOS parameters to fall in FEV1 of 20% were measured and compared with changes in the spirometry parameters. After bronchial challenge test subjects were divided into two groups: the group with BHR (group 1) and that without BHR (group 2). Results. The mean age of participants was 25.7 ± 5.7 years, and 50.5% were men. Out of the total number of subjects with allergy rhinitis, 56 (58.9%) had a positive BPT. After bronchoprovocation an average increase in the group 1 was 88.15% for Rrs5, 111.98% for Fres, and for AX 819.69%. The high degree of correlation between the IOS and spirometry was proven in the group 2, while the whole group 1 had a weak correlation between parameters of these two methods. High sensitivity and low specificity for Rrs5 and Fres compared to FEV1 in diagnosing BHR was proven. Conclusion. The study demonstrated a high prevalence of BHR in the study group of patients with persistent allergic rhinitis, poor correlation in relation to the spirometric measurements in the group with BHR and a high sensitivity and low specificity of IOS for the detection of early changes in the airways.

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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/VSP160407236K
objavljen u SCIndeksu: 26.01.2018.
metod recenzije: dvostruko anoniman

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