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Engrami - časopis za kliničku psihijatriju, psihologiju i granične discipline
2003, vol. 25, br. 4, str. 23-30
jezik rada: srpski
neklasifikovan
Lečenje depresije u Parkinsonovoj bolesti
Univerzitet u Beogradu, Medicinski fakultet, Klinički centar Srbije

Sažetak

Pored poznatih motornih simptoma Parkinsonova bolest (PB) je često udružena sa kognitivnim i psihijatrijskim morbiditetom. Depresija je najčešća psihijatrijska komplikacija udružena sa PB. Srednja vrednost učestalosti depresije povezane sa PB iznosi 43% (u rasponu od 4-70%). Farmakoterapija sa antidepresivima je najpouzdanija za tretman depresije u PB. Antidepresivi koji se primenjuju kod obolelih od PB su triciklični antidepresivi (TCA), selektivni inhibitori ponovnog preuzimanja serotonina (SSRI), inhibitori monoamino oksidaze (MAOI) i noviji antidepresivi ali su TCA jedina grupa antidepresiva koja je pažljivo ispitana (duplo-slepe, placebo-kontrolisane studije) u odnosu na njihovo antidepresivno dejstvo kod PB. Elektrokonvulzivna terapija (EKT) takođe predstavlja jedan od terapijskih modaliteta za depresiju u PB, sa povoljnim tranzitornim učinkom na motornu funkciju. Novije studije sugerišu terapeutski potencijal transkranijalne magnetne stimulacije (TMS) u depresiji udruženoj sa PB. Duplo slepe prospektivne kliničke studije su neophodne za procenu sigurnosti i efikasnosti antidepresiva i njihovog uticaja na motoriku u tretmanu depresije u PB.

Ključne reči

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