članak: 1 od 1  
Archives of Biological Sciences
2010, vol. 62, br. 1, str. 39-45
jezik rada: engleski
naučni članak
doi:10.2298/ABS1001039K

Mitotska aktivnost glatkih mišićnih ćelija mioma - da li hormonska stimulacija utiče na broj mitoza?
aKatedra za ginekologiju i akušerstvo, Medicinski fakultet, Kragujevac
bUniverzitet u Kragujevcu, Medicinski fakultet
cUniverzitet u Beogradu, Medicinski fakultet, Institut za histologiju i embriologiju
dOdeljenje za ginekologiju i akušerstvo, Zdravstveni centar, Sremska Mitrovica

Sažetak

Miomi nastaju usled povećane mitotske aktivnosti (proliferacije) glatkih mišićnih ćelija. U ovom radu ispitivani su patohistološki uzorci 176 mioma i pripadajućih endometrijuma, dobijenih nakon histerektomije od pacijentkinja u proliferativnoj i u sekretornoj fazi menstrualnog ciklusa. Određivana je mitotska aktivnost ćelija mioma i endometrijuma u obe faze i utvrđeno je da je srednja vrednost broja mitoza u proliferativnoj fazi značajno je veća u odnosu na sekretornu fazu ciklusa, kao i da u proliferativnoj fazi ciklusa postoji statistički značajna konvergentna asocijacija broja mitoza u endometrijumu i u miomima. Broj mitoza u endometrijumu je statistički značajno veći u odnosu na broj mitoza u miomu u obe faze menstrualnog ciklusa.

Ključne reči

Mitotic activity; myoma; menstrual cycle

Reference

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