članak: 1 od 1  
Archives of Biological Sciences
2011, vol. 63, br. 3, str. 597-601
jezik rada: engleski
naučni članak
doi:10.2298/ABS1103597S
Differential in vivo regulation of TH and DBH mRNA in rat atria by maprotiline and fluoxetine
(naslov ne postoji na srpskom)
Spasojević Natašaa, Jovanović P.a, Spasojević-Tišma Veraa, Đelić N.b, Dronjak Slađanaa
aInstitut za nuklearne nauke Vinča
bUniverzitet u Beogradu, Fakultet veterinarske medicine, Katedra za biologiju


Projekat Ministarstva nauke Republike Srbije, br. 173044 and 173023

Sažetak

(ne postoji na srpskom)
It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamineβ-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo.

Ključne reči

antidepressants; catecholamine enzymes; gene expression; atria; ventricles; rats

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