članak: 1 od 1  
Acta chirurgica iugoslavica
2009, vol. 56, br. 4, str. 153-158
jezik rada: engleski
stručni članak
doi:10.2298/ACI0904153B

Kontrola bolnih lezija kičme prouzrokovanih multiplim mielomom primenom perkutano aplikovanog akrilnog cementa
aInstitute of Radiology, Clinical Center, Niš
bClinic for haemathology, Clinical Center, Niš

Sažetak

Podaci i cilj rada: spinalne lezije sa izraženom destrukcijom kosti su česta lokacija u bolesnika sa multiplim mielomom što dovodi do ozbiljnih kliničkih simptoma. Cilj ove studije je evaluacija terapijskog efekta perkutane vertebroplastike (PVP) u tretmanu lezija pršljenskih tela u bolesnika obolelih od multiplog mieloma. Bolesnici i metode: Dvadeset devet bolesnika (55 pršljenskih tela) tretirano je nakon kompletne dijagnostičke obrade, pripreme i obezbeđenja pristanka na intervenciju. Pozicioniranje igle i ubrizgavanje akrilatnog cementa vršeno je pod kontrolom fluoroskopije. Rezultati: Prosečna vrednost vizuelno analognog skora smanjena je sa 7,8 pre na 2,3 posle intervencije. Curenje cementa u meka tkiva bilo je prisutno na 9 tretiranih nivoa, manje epiduralne količine cementa na 5, pojava cementa u perivertebralnim venama u 4 te u intervertebral nim diskusima u 3 nivoa bez kliničkih manifestacija. Efekti PVP su bili stabilni u periodu praćenja od 12 meseci. Subjektivna procena ishoda intervencije pokazala je poboljšanje od 1,45 (bol), 1.15 (pokretljivost) i 1,23 (korišćeni lekovi). Bol u leđima se ponovo javio u 9 bolesnika usled pojave novih lezija na nivoima koji nisu tretirani. Zaključak: U našoj seriji, PVP bolnih lezija uzrokovanih multiplim mielomom obezbedila je neposredno i dugotrajno obezboljavanje. Procedura je sigurna a, uprkos prisutnog curenja cementa, može biti izvođena u ambulantnih bolesnika.

Ključne reči

perkutana vertebroplastika; bol u leđima; multipli mijelom

Reference

Barr, J.D., Barr, M.S., Lemley, T.J., Mccann, R.M. (2000) Percutaneous vertebroplasty for pain relief and spinal stabilization. Spine, 25(8): 923-8
Callander, N.S., Roodman, G.D. (2001) Myeloma bone disease. Semin Hematol, 38(3): 276-85
Cortet, B., Cotton, A., Boutry, N., i dr. (1997) Percutaneous vertebroplasty in patients with osteolytic metastases or multiple myeloma. Rev Rheum Engl Ed, 64, str. 177-183
Deramond, H., Depriester, C., Toussaint, P., i dr. (1997) Percutaneous vertebroplasty. Semin Muskuloskel Radiol, 1:285- 295
Deramond, H., Galibert, P., Debussche, C., i dr. (1990) Percutaneous Vertebroplasty with methyl-methacrylate: Technique, method, results. Radiology, 177:352
Dudeney, S., Lieberman, I.H., Reinhardt, M., Hussein, M. (2002) Kyphoplasty in the treatment of osteolytic vertebral compression fractures as a result of multiple myeloma. J Clin Oncol, 20(9): 2382-7
Evans, A.J., Jensen, M.E., Kip, K.E., Denardo, A.J., Lawler, G.J., Negin, G.A., Remley, K.B., Boutin, S.M., Dunnagan, S.A. (2003) Vertebral compression fractures: pain reduction and improvement in functional mobility after percutaneous polymethylmethacrylate vertebroplasty retrospective report of 245 cases. Radiology, 226(2): 366-72
Fourney, D.R., Abi, D., Lang, F.F., Mccutcheon, I.E., Gokaslan, Z.L. (2001) Use of pedicle screw fixation in the management of malignant spinal disease: experience in 100 consecutive procedures. J Neurosurg, 94(1 Suppl): 25-37
Galibert, P., Deramond, H., Rosat, P., le Gars, D. (1987) Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie, 33(2): 166-8
Gangi, A., Kastler, B.A., Dietemann, J.L. (1994) Percutaneous vertebroplasty guided by a combination of CT and fluoroscopy. AJNR Am J Neuroradiol, 15(1): 83-6
Gilbert, H.A., Kagan, A.R., Nussbaum, H., Rao, A.R., Satzman, J., Chan, P., Allen, B., Forsythe, A. (1977) Evaluation of radiation therapy for bone metastases: Pain relief and quality of life. AJR Am J Roentgenol, 129(6): 1095-6
Gupta, A.K., Purkayastha, S., Kapilamoorthy, T.R., i dr. (2006) Management of painful neoplastic spinal lesions using percutaneous acrylic cement injection. Rivista di Neuroradiologia, 19, 236-244
Kaemmerlen, P., Thiesse, P., Bouvard, H., Biron, P., Mornex, F., Jonas, P. (1989) Percutaneous vertebroplasty in the treatment of metastases. Technic and results. J Radiol, 70(10): 557-62
Lapras, C., Mottolese, C., Deruty, R., Lapras, C., Remond, J., Duquesnel, J. (1989) Percutaneous injection of methyl-metacrylate in osteoporosis and severe vertebral osteolysis (Galibert's technic). Ann Chir, 43(5): 371-6
Lieberman, I.H., Dudeney, S., Reinhardt, M.K., Bell, G. (2001) Initial outcome and efficacy of 'kyphoplasty' in the treatment of painful osteoporotic vertebral compression fractures. Spine, 26(14): 1631-8
Mcdonald, R.J., Trout, A.T., Gray, L.A., i dr. (2008) Vertebroplasty in multiple myeloma: Outcomes in a large patients series. AJNR, 29, str. 642-48
Schachar, N.S. (2001) An update on the nonoperative treatment of patients with metastatic bone disease. Clin Orthop Relat Res, (382): 75-81
Shepherd, S. (1988) Radiotherapy and the management of metastatic bone pain. Clin Radiol, 39(5): 547-50
Wenger, M., Markwalder, T.M. (1999) Surgically controlled, transpedicular methyl methacrylate vertebroplasty with fluoroscopic guidance. Acta Neurochir (Wien), 141(6): 625-31