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Medicinski podmladak
2005, vol. 56, iss. 1, pp. 29-32
article language: Serbian
Professional Paper
Glikemija našte i/ili test oralne glukozne tolerancije (OGTT) u dijagnozi poremećaja metabolizma glukoze
(title is not available in english)
aUniversity of Belgrade, Faculty of Medicine
bUniverzitet u Beogradu, Medicinski fakultet, KBC 'Dr Dragiša Mišović'

Abstract

Diabetes mellitus is a chronic metabolic disease with constant rising frequency and long evolution before clinical manifestations. Aim: to determine the importance, necessity and sufficiency of fasting glycaemia as well as of oral glucose tolerance tests (OGTT) in the diagnose of glucose metabolism impairment. Material and methods: The research was conducted using data from ambulance laboratory protocols on 217 non-selected patients (144 female/73 male, average age 46+-9 years) who where being tested with fasting glvcaemia and the standardized oral glucose tolerance test with 75 gr of glucose during a period of one year. When diagnosing glucose metabolism impairment the criteria of our National guide of good clinical practice for Diabetes mellitus where used. Statistical analysis was done using Student t-test and STATISTICA 4.5(StatStof, Tulsa, OK, USA). Results and discussion: The results of our research showed that as the patients got older (especially between the age of 35-44 and 45-54) the percentage of those diagnosed with a glucose metabolism impairment (glucose intolerance or diabetes mellitus) on the basis of glycaemia in 120. minute of OGTT was increasing. Prediction value of fasting glycaemia was 73% for normal glucose tolerance and only 65% for diabetes mellitus. The value of fasting glycemia below 6.1 mmol/L was false negative for 4% of patients with diabetes mellitus, while this value equal or above 7.0 mmol/L was false positive for even 15% of patients with normal glucose tolerance. Conclusion: Measurement of fasting glycaemia as a method of screening wider population, but for a precise diagnoses of a particular glucose metabolism impairement diagnosing glycaemia in the 120. minute of OGTT is necessary as well.

Keywords

glycaemia on an empty stomach; oral glucose tolerance test; glucose metabolism imbalance

References

American Diabetes Association (2005) Standards of medical care for patients with diabetes mellitus. Diabetes Care, 28: S4-S36
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 26 Suppl 1: S5-20
Lalić, N.M. (2004) Novine u dijagnostici i terapiji dijabetesa. Medicinski podmladak, vol. 55, br. 1-2, str. 89-92
Manojlović, D., ur. (2003) Interna medicina. Beograd: Zavod za udžbenike
mc Caty, D., Zimmet, P. Diabetes 1994 to 2010. Global Estmates and Production
Milenković, T., i dr. (2004) Imaired fasting glucose, impaired glucose tolerance and diabetes mellitus. in: Second Macedonian Congress on Endocrinology. Diabetes and Metabolic Disorders with International Participation, 29.09.- 02.10.Ohrid. Macedonia, Abstract br. 27
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