2005, vol. 56, iss. 1, pp. 29-32
article language: Serbian
Glikemija našte i/ili test oralne glukozne tolerancije (OGTT) u dijagnozi poremećaja metabolizma glukoze
(title is not available in English)
aUniversity of Belgrade, Faculty of Medicine
bUniverzitet u Beogradu, Medicinski fakultet, KBC 'Dr Dragiša Mišović'
Diabetes mellitus is a chronic metabolic disease with constant rising frequency and long evolution before clinical manifestations. Aim: to determine the importance, necessity and sufficiency of fasting glycaemia as well as of oral glucose tolerance tests (OGTT) in the diagnose of glucose metabolism impairment. Material and methods: The research was conducted using data from ambulance laboratory protocols on 217 non-selected patients (144 female/73 male, average age 46+-9 years) who where being tested with fasting glvcaemia and the standardized oral glucose tolerance test with 75 gr of glucose during a period of one year. When diagnosing glucose metabolism impairment the criteria of our National guide of good clinical practice for Diabetes mellitus where used. Statistical analysis was done using Student t-test and STATISTICA 4.5(StatStof, Tulsa, OK, USA). Results and discussion: The results of our research showed that as the patients got older (especially between the age of 35-44 and 45-54) the percentage of those diagnosed with a glucose metabolism impairment (glucose intolerance or diabetes mellitus) on the basis of glycaemia in 120. minute of OGTT was increasing. Prediction value of fasting glycaemia was 73% for normal glucose tolerance and only 65% for diabetes mellitus. The value of fasting glycemia below 6.1 mmol/L was false negative for 4% of patients with diabetes mellitus, while this value equal or above 7.0 mmol/L was false positive for even 15% of patients with normal glucose tolerance. Conclusion: Measurement of fasting glycaemia as a method of screening wider population, but for a precise diagnoses of a particular glucose metabolism impairement diagnosing glycaemia in the 120. minute of OGTT is necessary as well.
glycaemia on an empty stomach; oral glucose tolerance test; glucose metabolism imbalance