članak: 1 od 1  
Srpski arhiv za celokupno lekarstvo
2002, vol. 130, br. 5-6, str. 213-216
jezik rada: srpski
prikaz knjige
doi:10.2298/SARH0206213F

Primarna bilijarna ciroza
Univerzitet u Beogradu, Medicinski fakultet, KBC 'Bežanijska kosa'

e-adresa: branka_filipovic@yahoo.com

Sažetak

Primerna bilijarna ciroza je hronično zapaljenje jetre s holestazom, koje se odlikuje promenama na intrahepatičnim žučnim kanalićima u ranim stadijumima i na parenhimu jetre kada je već bolest napredovala. Oboljenje postepeno progreduje u kliničku sliku bilijarne ciroze. Primarna bilijarna ciroza prvenstveno zahvata osobe ženskog pola svih rasa i socijalnog statusa starosti između 35 i 60 godina. Naša bolesnica, žena starosti 78 godina hospitalizovana je radi lečenja hipertrofične kardiomiopatije. U toku rutinskog ispitivanja laboratorijskih analiza, registrovani su znaci holestaze: visoki nivo alkalne fosfataze i gama-glutamil-transferaze kombinovani s trombocitopenijom, verovatno autoimunskog porekla. U serumu je utvrđena hiperholesterolemija (7,8 mmol/L), udružena s normalnim nivoima triglicerida. Glavno dijagnostičko merilo za primarnu bilijarnu cirozu bio je visok titar antimitohondrijskih antitela u serumu, koji je kod naše bolesnice iznosio 1:640. Lek izbora u terapiji primarne bilijarne ciroze jeste ursodeoksiholna kiselina, koji smo primenili kod naše bolesnice. Naša bolesnica s primernom bilijarnom cirozom interesantna je zbog komorbiditeta s oboljenjem srca, koje je prikrivalo oboljenje jetre.

Ključne reči

primarna bilijarna ciroza; antimitohondrijska antitela

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