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2005, vol. 133, br. 7-8, str. 384-387
Onkogeni virusi i njihova uloga u nastanku tumora
aUniverzitet u Beogradu, Medicinski fakultet, Institut za mikrobiologiju i imunologiju
bVojnomedicinska akademija, Beograd

e-adresatajm@eunet.yu
Ključne reči: humani onkovirusi; molekulski mehanizmi onkogeneze; RNK onkovirusi; DNK onkovirusi
Sažetak
Onkogeni virusi su tumorski DNK i RNK virusi koji imaju sposobnost da maligno transformišu ćeliju. Ono što je zajedničko za obe grupe virusa jeste da svoj genetski materijal ugrađuju u genom ćelije u potpunosti ili jedan njegov deo (DNK virusi), ili se kao provirusni DNK integrišu u ćelijski hromozom (RNK virusi). Inficirana ćelija se fenotipski menja, nastaju promene u ponašanju ćelije, odnosno promene na nivou rasta i razmnožavanja. DNK onkogeni virusi imortalizuju samo nepermisivne ćelije u kojima može da se izvrši ekspresija ranih virusnih gena, čiji proizvodi udruženi sa proizvodima antionkogena mogu da izazovu transformaciju ćelije. Tumorski RNK virusi izazivaju malignu transformaciju i permisivnih i nepermisivnih ćelija prevashodno mehanizmom aktivacije protoonkogena. U odnosu na način kojim izazivaju onkogenezu, razlikuju se tri grupe RNK onkovirusa. Tumorski DNK virusi pripadaju različitim familijama DNK virusa, dok RNK virusi pripadaju samo familiji retrovirusa. Maligna transformacija ćelija koja je izazvana virusima predstavlja samo etapu u složenom procesu nastanka tumora.
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O članku

jezik rada: srpski
vrsta rada: članak
DOI: 10.2298/SARH0508384C
objavljen u SCIndeksu: 02.06.2007.