članak: 1 od 1  
Acta veterinaria
2002, vol. 52, br. 2-3, str. 137-150
jezik rada: engleski
neklasifikovan
doi:10.2298/AVB0203137M

Uticaji blokade endotelinskih receptora na TDK postishemične eksperimentalne akutne bubrežne insuficijencije
aInstitut za medicinska istraživanja, Beograd
bUniversidad de Salamanca - Instituto Reina Sofia de Investigacipn Nefrologica - Departamento de Fisiologia, Spain
cUniverzitet u Beogradu, Medicinski fakultet, Klinički centar Srbije
dUniverzitet u Beogradu, Medicinski fakultet, Institut za patološku anatomiju

Sažetak

Uticaji blokade receptora endotelinskih peptida na tok postishemične eksperimentalne akutne bubrežne insuficijencije (ABI), predstavljali su glavni cilj naših istraživanja. Eksperimenti su izvođeni na odraslim pacovima Wistar soja. Urađena je netrektomija desnog bubrega, a leva bubrežna arterija je klemovana u trajanju od 45 minuta. Eksperimentalne grupe su prekofemoralne vene primale Hi bpsentan (antagonist ETA/ETB-receptora) Hi fiziološki rastvor, kontinuirano, 20 minuta pre, tokom i 20 minuta posle perioda ishemije. Svi parametri su mereni 24 časa nakon perioda ishemije. Dobijeni rezultati jasno pokazuju da bozentan iskazuje povoljne uticaje na tok ABI. Bozentan poboljšava bubrežne hemodinamske i funkcionalne parametre, a lezije epitelnih ćelija tubula (glavnih mesta oštećenja u ABI), su manje izražene kod pacova tretiranih bosentanom, negp kod kontrolnih životinja sa ABI. Sve to navodi na zaključak da endotelini imaju uticaja u razvoju ishemično/reperfuzionih oštećenja u ABI i da bosentan poseduje potencijal za primenu u kliničkoj praksi.

Ključne reči

acute renal failure; biochemistry; bosentan; endothelin receptor blockade; haemodynamic; tubular injury

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