članak: 1 od 1  
Acta veterinaria
2006, vol. 56, br. 2-3, str. 121-136
jezik rada: engleski
neklasifikovan
doi:10.2298/AVB0603121S

Hematološki i biohemijski parametri kod zalučene prasadi hranjene koncentratom kontaminiranim zearalenonom uz dodatak klinoptilolita
aFaculty of Agriculture, Osijek, Croatia
bFaculty of Agriculture, Zagreb, Croatia
cClinical Hospital Osijek, Croatia
dFaculty of Veterinary Medicine, Zagreb, Croatia
eCentar for Livestock Improvement, Osijek

e-adresa: marcela.speranda@pfos.hr

Sažetak

U radu je istraživan utjecaj zeolita klinoptilolita (CLIN) na hematološke i neke metaboličke pokazatelje u serumu odbite prasadi hranjenje hranom s povišenom razinom zearalenona (ZEN) tijekom 14 dana. Istraživanje je provedeno na četiri skupine odbite prasadi u dobi od 40. do 54. dana. Sve su skupine hranjene krmnom smjesom za prasad u porastu, koja je sadržavala 20% sirovih proteina i 12.57 MJ ME/kg. Prva kontrolna skupina (C1) životinja hranjena je smjesom bez dodatka adsorbenta mikotoksina Min-a-Zel Plus® i bez dodatka zearalenona. Druga kontrolna skupina (C2) hranjena je hranom u koju je umješano 0.2% modificiranog klinoptilolita (Min-a-Zel Plus®; razina ZEN<5.1 ng/g). U hranu za prasad pokusne skupine (E1) dodano je 3 mg/kg zearalenona (Sigma-Aldrich Co) i 0.2% pripravka Min-a-Zel Plus®. Drugoj pokusnoj skupini (E2) u hranu je umiješano 3 mg/kg zearalenona. Estrogeni efekt zearalenona očitovao se u sinergističnom djelovanju s inzulinom, što se očitovalo povišenom razinom ukupnih proteina u serumu, nižom razinom glukoze, triglicerida, serumskog željeza, povišenom razinom kolesterola i višom aktivnosti transaminaza. Metabolički antiestrogeni učinak ZEN utvrđen je u E2 skupini, dok je u E1 skupini utvrđen agonistički efekt ZEN zbog smanjene resorpcije zahvaljujući djelovanju klinoptilolita.

Ključne reči

Reference

Alexopoulos, C. (2001) Association of Fusarium mycotoxicosis with failure in applying an induction of parturition program with PGF2 alpha and oxytocin in sow. Theriogenol, 55, 1745-57
Alm, H., Greising, T., Brussow, K.P., Torner, H., Tiemann, U. (2001) The influence of mycotoxin (alphazearalenol) on maturation of pig oocytes and embryo culture in vitro. Arch fur Tier, 44, 159
Basmacioglu, H., Oguz, H., Ergul, M., Col, R., Birdane, Y.O. (2005) Effect of dietary esterified glucomannan on performance, serum biochemistry and haematology in broilers exposed to aflatoxin. Czech Journal of Animal Science, 50, 31-9
Bauer, J., Wertmer, R., Gedek, B. (1980) Zur Kontamination von Futtermitteln mit toxinbildenden Fusariumstämmen und deren Toxinen. Wien tierarztl Mschr, 67, 282-8
Beitz, D.C. (2004) Lipid metabolism. u: Reece W.O. (ur.) Dukes' Physiology of Domestic Animals, Ithaca, London: Cornell University Press, str. 516-34
Bullock, R. (2002) New drugs for Alzheimer's disease and other dementias. Br J Psychiatry, 180: 135-9
Clark, J.F., Khuchua, Z., Kuznetsov, A., Saks, V.A., Venturaclapier, R. (1993) Compartmentation of creatine kinase isoenzymes in myometrium of gravid guinea-pig. J Physiol, 466, 553-72
Dacasto, M., Rolando, P., Nachtmann, C., Ceppa, L., Nebbia, C. (1995) Zearalenone mycotoxicosis in piglets suckling sows fed contaminated grain. Vet Human Tox, 37, 359-61
Doll, S., Danicke, S., Valenta, H., Flachowsky, G. (2004) In vitro studies on the evaluation of mycotoxin detoxifying agents for their efficacy on deoxynivalenol and zearalenone. Archives of Animal Nutrition, 58, 4, 311-24
Dwyer, M.R., Kubena, L.F., Harvey, R.B., Mayura, K., Sarr, A.B., Buckley, S., Bailey, R.H., Phillips, T.D. (1997) Effects of inorganic adsorbents and cyclopiazonic acid in broiler chickens. Poultry Science, 76, 8, 1141-9
Enemark, J.M.D., Frandsen, A.M.S., Thilsing-Hansen, T., Jorgensen, R.J. (2003) Aspects of physiological effects of sodium zeolite A supplementation in dry, non-pregnant dairy cows fed grass silage. Acta Vet Scand, Suppl 97, 97-117
Fokas, P., Zervas, G., Fegeros, K., Zoipoulos, P. (2004) Assessment of Pb retention coefficient and nutrient utilization in growing pigs diets with added clinoptilolite. Anim Feed Sci Technol, 117, 121-9
Gajecka, M., Jakimiuk, E., Polak, M., Otrocka-Domagala, I., Janowski, T., Zwierzchowski, W., Obremski, K., Zielonka, L., Apoznanski, J., Gajecki, M. (2004) Zearalenone applied per os provides adverse effects in structure of chosen parts of bitch reproductive system. Polish J Vet Sci, 7, 1, 59-66
Galtier, P. (1999) Biotransformation and fate of mycotoxins. J Toxicol. Toxin Rev, 18 (3-4), str. 295-312
Gaumy, J.L., Bailly, J.D., Burgat, V., Guerre, P. (2001) Zearalenone: Properties and experimental toxicity. Revue Med Vet, 3, 219-234
Goldfien, A., Monroe, S.E. (1997) Ovaries. u: Greenspan F.S., Strewler G.J. (ur.) Basic and Clinical Endocrinology, Prentice Hall, str. 434-86
Hagler, W.M., Danko, G., Horvath, L., Palyusik, M., Mirocha, C.J. (1980) Transmission of zearalenone and its metabolite into ruminant milk. Acta Vet Acad Sci Hung, 28(2): 209-16
Heringa, M. (2003) Review on raloxifene: Rrofile of a selective estrogen receptor modulator. Int J Clin Pharmacol Therap, 41, 1, 331-45
Horugel, K., Vergara, H. (2003) Influence of mycotoxins on growth and onset of puberty in growing female pigs. Prakt Tierarzt, 84, 8, 611-4
Ivković, S., Deutsch, U., Silberbach, A., Walraph, E., Mannel, M. (2004) Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in imunodeficiency: Effects on the immune system. Advances in Therapy, 21, 135-47
Jurjević, Z., Solfrizzo, M., Cvjetković, B., Avantaggiato, G. (1999) Ochratoxin A and Fumonisins (B1 i B2) in maize from Balkan nephropathy endemic and non endemic areas of Croatia. Mycotoxin Res, 15, 67-80
Kalliamurthy, J., Geraldine, P., Thomas, P.A. (1997) Effects of zearalenone on food consumption, growing rate, organ weight and serum testosteron level in male rats. J Environ Biol, 18, 2, 115- 20
Kaneko, J.J., Harvey, J.W., Bruss, M.L. (1997) Clinical biochemistry of domestic animals. New York-San Diego, itd: Academic Press
Kaye, A.M., Kim, T.Y., Kohen, F., Somjen, D. (1997) Anabolic effects of estrogen and parathyroid hormone on skeletal tissues: The use of creatine kinase B activity as a response marker. Arch Gerontol Geriatr, 24(2): 197-209
Kececi, T., Oguz, H., Kurtoglu, V., Demet, O. (1998) Effects of polyvinylpolypyrrolidone, synthetic zeolite and bentonite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis. Br Poult Sci, 39(3): 452-8
Kitagawa, M., Tashiro, F., Ueno, Y. (1982) Interaction between zearalenone, an estrogenic mycotoxin, and the estrogen receptor of the rat brain. Proc Japan Assoc Mycotoxicol, 15, 28-30
Kuiper, G.G., Lemmen, J.G., Carlsson, B., Corton, J.C., Safe, S.H., van der Saag, P.T., van der Burg, B., Gustafsson, J.A. (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology, 139(10): 4252-63
Kyriakis, S.C., Papaioannou, D.S., Alexopoulus, C., Polizopoulou, Z., Tzika, E.D., Kyriakis, C.S. (2002) Experimental studies on safety and efficacy of the dietary use of a clinoptilolite-rich tuff in sows: A review of recent research in Greece. Microporous and Mesoporous Materials, 51, 65-74
Lawlor, P.G., Lynch, P.B. (2001) Mycotoxins in pig feeds, 1: Source of toxins, prevention and management of mycotoxicosis. Irish Veterinary Journal, 54, 3, 117-20
Lindemann, M.D., Blodgett, D.J., Kornegay, E.T., Schurig, G.G. (1993) Potential ameliorators of aflatoxicosis in weanling/growing swine. J Anim Sci, 71(1): 171-8
Maaroufi, K., Chekir, L., Creppy, E.E., Ellouz, F., Bacha, H. (1996) Zearalenone induces modifications of haematological and biochemical parameters in rats. Toxicon, 34, 5, 535-40
Maggiolini, M., Vivacqua, A., Fasanella, G., Recchia, A.G., Sisci, D., Pezzi, V., Montanaro, D., Musti, A.M., Picard, D., Ando, S. (2004) The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem, 279(26): 27008-16
Makela, S., Davis, V.L., Tally, W.C., Korkman, J., Salo, L., Vihko, R., Santti, R., Korach, K.S. (1994) Dietary estrogens act through estrogen receptor-mediated processes and show no antoestrogenicity in cultured breast cancer cells. Environ Health Perspect, 102, 572-81
Martin-Kleiner, I., Flegar-Meštrić, Z., Zadro, R., Breljak, D., Stanović, J.S., Stojković, R., Marušić, M., Radačić, M., Boranić, M. (2001) The effect of the clinoptilolite on serum chemistry and hematopoiesis in mice. Food Chem Toxicol, 39, 717-27
Mueller, S.O., Simon, S., Chae, K., Metzler, M., Korach, K.S. (2004) Phytoestrogen and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ER alpha), and ER beta in human cells. Toxicol Sci, 80, 1, 14-25
Murata, H., Shimida, N., Yoshioka, M. (2002) Suppressive effect of zearalenone, an estrogenic mycotoxin, on bovine neutrophil chemiluminescence. Vet Human Tox, 44, 2, 83-6
Nogowski, L. (1999) Effects of phytoestrogen-coumestrol on lipid and carbohydrate metabolism in young ovariectomized rats may be independent of its estrogenicity. J Nutr Biochem, 10(11): 664-9
Nogowski, L., Nowak, K.W., Kaczmarek, P., Mackowiak, P. (2002) The influence of cumestrol, zearalenone, and genistein administration on insulin receptors and insulin secretion in ovariectomized rats. J Recept Signal Transduct Res, 22, 449-57
Ojeda, S.R. (2000) Female Reproductive Function. u: Griffin, J.E.and Ojeda, S.R. (ur.) Textbook of physiology, Oxford University Press, str. 202-42
Olver, M.D. (1997) Effect of feeding clinoptilolite (zeolite) on the performance of three strains of laying hens. Br Poult Sci, 38(2): 220-2
Papaioannou, D.S., Kyriakis, S.C., Papasteridiadis, A., Roumbies, N., Yannakopoulos, A., Alexopoulos, C. (2002) A field study on the effect of in-feed inclusion of a natural zeolite (clinoptilolite) on health status and performance of sows/gilts and their litters. Res Vet Sci, 72, 51-9
Parentmassin, D., Parchment, R.E. (1998) Haematotoxicity of mycotoxins. Rev Med Vet, 149, 6, 591-8
Pavelic, K., Katic, M., Sverko, V., Marotti, T., Bosnjak, B., Balog, T., Stojkovic, R., Radacic, M., Colic, M., Poljak-Blazi, M. (2002) Immunostimulatory effect of natural clinoptilolite as a possible mechanism of its antimetastatic ability. J Cancer Res Clin Oncol, 128(1): 37-44
Pentecost, B.T., Mattheiss, L., Dickerman, H.W., Kumar, S.A. (1990) Estrogen regulation of creatin kinase-B in the rat uterus. Molecular Endocrinology, 4, 1000-10
Perfumo, C.J., Sanguinetti, H.R., Giorgio, N., Armocida, A.D., Machuca, M.A., Massone, A.R., Risso, M.A., Aguirre, J.I., Idiart, J.R. (2002) Rectal stricture of postmortem examined pigs in a farrow-to-finishing unit, Considerations about the prevalence, pathology, etiology and pathogenesis. Archivos de Medicina Veterinaria, 34, 245-52
Pfaffl, M.W., Lange, I.G., Daxenberger, A., Meyer, H.H. (2001) Tissue-specific expression pattern of estrogen receptors (ER): Quantification of ER alpha and ER beta mRNA with real-time RT-PCR. APMIS, 109(5): 345-55
Placinta, C.M., d'Mello J.P.F., Macdonald, A.M.C. (1999) A review of worldwide contamination of cereal grains and animal feed with Fusarium mycotoxins. Anim Feed Sci Technol, 78, 21-37
Pond, W.G. (1985) Effect of dietary protein and clinoptilolite levels on weight gain, feed utilization and carcass measurments in finishing lambs. Nutr Rep Int, 32, 855-62
Pond, W.G., Yen, J.T. (1983) Protection by clinoptilolite or zeolite NaA against cadmium-induced anemia in growing swine. Proc Soc Exp Biol Med, 173, 332-7
Pond, W.G., Yen, J.T., Varel, V.H. (1988) Response of growing swine to dietary copper and clinoptilolite supplementation. Nutr Rep Intern, 37, 797-803
Poulsen, P.H., Oksbjerg, N. (1995) Effects of dietary inclusion of a zeolite (clinoptilolite) and performance and protein metabolism of young growing pigs. Anim Feed Sci Technol, 53, 297- 303
Powell-Jones, W., Raeford, S., Lucier, G.V. (1981) Binding properties of zearalenone mycotoxins to hepatic estrogens receptors. Mol Pharmacol, 21, 35-42
Ryberg, M., Nielsen, D., Osterlind, K., Andersen, P.K., Skovsgaard, T., Dombernowsky, P. (2005) Predictors of central nervous system metastasis in patients with metastatic breast cancer. A competing risk analysis of 579 patients treated with epirubicin-based chemotherapy. Breast Cancer Res Treat, 91(3): 217-25
Somjen, D., Waisman, A., Kaye, A.M. (1996) Tissue selecive action of tamoxifen methiodide, raloxifene and tamoxifen on creatine kinase B activity in in vitro and in vivo. J Ster Biochem Mol Biol, 59, 389-96
Somjen, D., Knoll, E., Kohen, F., Stern, N. (2001) Effects of phytoestrogens on DNA synthesis and creatine kinase activity in vascular cells. Am J Hypertens, 14(12): 1256-62
Somjen, D., Amir-Zaltsman, Y., Gayer, B., Kulik, T., Knoll, E., Stern, N., i dr. (2002) 6-Carboxymethyl genistein: A novel selective oestrogen receptor modulator (SERM) with unique, differential effects on the vasculature, bone and uterus. Journal of Endocrinology, 173, 415-427
Somjen, D., Knoll, E., Vaya, J., Stern, N., Tamir, S. (2004) Estrogen-like activity of licorice root constituents: Glabridin and glabrene in vascular tissues in vitro and in vivo. J Ster Biochem Mol Biol, 91, 147- 55
StatSoft Inc (2005) Statistica, data analysis software system version 7.1. www.statsoft.com
Stojić, V., Gagričin, M., Fratrić, N., Tomašević-Čanović, M.R., Kirovski, D. (1998) The effect of a clinoptilolite based mineral adsorbent on colostral immunoglobulin G absorption in newborn piglets. Acta Veterinaria, 48(1): 19-25
Stojšić, D., Stojković, M., Daković, A.S., Adamović, M., Tomašević-Čanović, M.R. (2004) Efikasnost organozeolita u preveniranju toksičnih efekata zearalenona kod jagnjadi. Acta veterinaria, vol. 54, br. 1, str. 53-62
Szuets, P.M., Mesterhazy, A., Falkay, G., Bartok, T. (1997) Early telarche symptoms in children and their relations to zearalenon contamination in foodstuffs. Cereal Res. Commun, 25, 3 part 1, 429-36
Tomašević-Čanović, M.R., Dumić, M., Vukićević, O., Daković, A., Milošević, S., Avakumović, Đ., i dr. (2000) Organomineral adsorbent of mycotoxins as an animal feed additive, procedure for production and application. Patent P-838-00
Tomašević-Čanović, M.R., Daković, A., Rottinghaus, G., Matijašević, S., Đuričić, M. (2003) Surfactant modified zeolites: New efficient adsorbents for mycotoxins. Microporous and mesoporous materials, 61, 173- 80
Tyler, R.D., Cowell, R.L. (1996) Classification and diagnosis of anemia. Comp Haematol Int, 6, 1-16
van de Walle, B., Hornez, L., Revillion, F., Lefebvre, J. (1989) Secretion of transferring by human breast cancer cells. Biochem Biophys Res Comm, 163, 1, 149-54
Ward, T.L., Watkins, K.L., Southern, L.L., Hoyt, P.G., French, D.D. (1991) Interactive effects of sodium zeolite-A and copper in growing swine: Growth, and bone and tissue mineral concentrations. J Anim Sci, 69(2): 726-33
Wood, G.E. (1992) Mycotoxins in foods and feeds in the United States. J Anim Sci, 70(12): 3941-9
Yiannikouris, A., Jouany, J.P. (2002) Mycotoxins in feeds and their fate in animals: A review. Animal Research, 51, 81-99
Zollner, P., Jodlbauer, J., Kleinova, M., Kahlbacher, H., Kuhn, T., Hochsteiner, W., Lindner, W. (2002) Concentration levels of zearalenone and its metabolites in urine, muscle tissue, and liver samples of pigs fed with mycotoxin-contaminated oats. J Agric Food Chem, 50(9): 2494-501