članak: 1 od 1  
Acta veterinaria
2008, vol. 58, br. 2-3, str. 111-120
jezik rada: engleski
neklasifikovan
doi:10.2298/AVB0803111S
Uticaj etanola na elektroencefalografske i bihejvioralne znake metafitom-indukovane audiogene epilepsije
Stanojlović Oliveraa, Petrović Bojanaa, Hrnčić D.a, Mladenović D.b, Rašić Aleksandraa, Šušić Veselinkac
aUniverzitet u Beogradu, Medicinski fakultet, Institut za fiziologiju
bUniverzitet u Beogradu, Medicinski fakultet, Institut za patološku fiziologiju
cSrpska akademija nauke i umetnosti (SANU), Beograd

e-adresa: solja@afrodita.rcub.bg.ac.yu

Sažetak

Cilj ovog rada je bio da se utvrdi da li udružena aktivnost metafita i audiogene stimulacije, koja dovodi do generalizovane refleksne epilepsije u pacova, može biti modifikovana etanolom. Pacovi su bili podeljeni u četri grupe koje su intraperitonealno (i.p) tretirane: fiziološkim rastvorom; metafitom (10 mg/kg); metafitom (10 mg/kg) + etanolom (2 g/kg) i etanolom (2 g/kg). Etanol je administriran životinjama koje su prethodno tretirane metafitom i koje su pokazivale epileptičke napade u prvih osam testiranja. Audiogena stimulacija je primenjivana u jednočasovnim intervalima počevši jedan sat nakon injekcije metafita i zatim, tokom svih 16 h trajanja eksperimenta. Za elektroencefalografsko (EEG) registrovanje u lobanje pacova su bile implantirane po tri pozlaćene elektrode. U EEG zapisu je observirana metafitom indukovana hipersinhronizovana epileptiformna aktivnost u formi šiljak talas kompleksa i grupisanih šiljaka dok je ponašanje definisano gradusima. Uočeni su efekti etanola koji značajno umanjuju EEG znake epilepsije, redukuju frekvenciju i povećavaju amplitudu talasa (dominiraju talasi i ). Etanol kompletno blokira sve manifestacije konvulzivnog ponašanja metafitom tretiranih životinja. Rezultati ovog eksperimenta ukazuju da etanol inhibira konvulzivno ponašanje i menja EEG znake metafitom indukovane audiogene generalizovane epilepsije.

Ključne reči

metaphit; seizures; ethanol; EEG; rat

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