članak: 1 od 1  
Acta veterinaria
2011, vol. 61, br. 2-3, str. 133-140
jezik rada: engleski
neklasifikovan
doi:10.2298/AVB1103133N

Efekti pinacidila - otvarača kalijumovih kanala na kontrakcije izolovanog negravidnog uterusa pacova izazvane kalijum hloridom
aUniverzitet u Beogradu, Medicinski fakultet
bUniversity of East Sarajevo, Faculty of Medicine, Foca, Federation BH
cUniverzitet u Beogradu, Fakultet veterinarske medicine

e-adresa: bukarica@rcub.bg.ac.rs

Projekat Ministarstva nauke Republike Srbije, br. TR 20027

Sažetak

U ovom radu su prikazani efekti pinacidila, koji ima osobinu da otvara kalijumove kanale, na kontrakcije izazvane kalijum hloridom na modelu izolovanog negravidnog uterusa ženki pacova tokom estrusa. Pinacidil dovodi do snažnije inhibicije kontrakcija izazvanih sa 20mM KCl (pD2= 6.57 μM) u poređenju sa kontrakcijama izazvanim sa 40 ili 80 mM KCl (pD2 = 5.11 i 5.19 μM). Poznato je da je glibenclamid selektivni blokator adenozin-3-fosfat senzitivnih K+ (KATP) kanala antagonizuje pinacidilom indukovanu kompetitivnu inhibiciju kontrakcija izazvanih pomoću 20 mM KCl-a. Međutim, pinacidilom indukovana inhibicija kontrakcija, izazvanih sa 40 i 80 mM KCl-a nije se mogla prevenirati glibenclamidom. Sposobnost pinacidila da dovede do potpune relaksacije negravidnog uterusa ženki pacova pre kontrakcije izazvane rastvorom kalijuma ukazuje na to da u relaksaciji učestvuje i mehanizam nezavisan od kalijumovih kanala.

Ključne reči

high K+ solution; KATP channels; pinacidil; rat uterus

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