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2009, vol. 25, br. 5-6-2, str. 703-711
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Kompleks respiratornog oboljenja goveda sa aspekta infekcije parainfluence-3 virusom
Complex of respiratory diseases in cattle from the aspect of parainfluenca-3 virus
aNaučni institut za veterinarstvo 'Novi Sad', Novi Sad bVeterinary Clinic 'Kendrišić', Šid
e-adresa: lazic@niv.ns.ac.rs
Ključne reči: BRDC; PI-3 virus; specific antibodies against PI-3 virus; beef cattle
Sažetak
Oboljenja organa respiratornog sistema goveda se smatraju najvećim zdravstvenim problemom današnjeg govedarstva. Među mnogobrojnim oboljenjima organa respiratornog sistema 'kompleks respiratornog oboljenja goveda' (Bovine Respiratory Disease Complex - BRDC) sigurno predstavlja najznačajnije oboljenje. BRDC se manifestuje teškim oblicima zapaljenja disajnih puteva i pluća, izazvanih virusima i bakterijama uz uticaj stresogenih faktora. Ipak se smatra da su glavni etiološki faktori ovog oboljenja virusi uz delovanje faktora stresa. Od mnogobrojnih virusnih agenasa najznačajniju ulogu u nastanku BRDC imaju: goveđi herpesvirus tip-1 (BHV-1), parainfluenca-3 virus (PI-3), goveđi respiratorni sincicijalni virus (BRSV), virus goveđe virusne dijareje (BVDV), dok su drugi virusi, npr. goveđi adeno i korona virus, ipak manjeg značaja. BRDC je česta pojava u govedarstvu u Srbiji, a posebno u sistemima intenzivnog odgoja tovne junadi. Etiopatogeneza, kliničke i patoanatomske karakteristike BRDC su u našoj stručnoj i naučnoj literaturi najčešće predstavljane sa aspekta infekcije BHV-1 i BVDV. Malo je literaturnih podataka koji ovo oboljenje predstavljaju sa aspekta infekcije virusom PI-3 i BRSV. Prema tome, cilj ovoga rada je da se prikaže pojava BRDC u jednom tovilištu junadi, industrijskog tipa, (broj junadi u turnusu iznosi od 800-1200) sa aspekta infekcije virusom PI-3. U radu je prikazana klinička slika, postupak izolacije virusa PI-3 i nalaz bakterijske mikroflore kod obolele junadi. Takođe, u radu je prikazan i imuni status kod 30 junadi (boks u kojem se pojavila infekcija) na virus PI-3. Imuni status je određivan utvrđivanjem nivoa specifičnih antitela protiv virusa PI-3 u momentu pojave bolesti, 3 i 6 nedelja posle pojave oboljenja i na kraju tova, odnosno 4 meseca posle pojave infekcije PI-3 virusom. Utvrđena geometrijska srednja vrednost titra antitela protiv ovog virusa je iznosila u momentu pojave oboljenja 14,58, tri i šest nedelja posle pojave oboljenja 45,25 i 54,44, a na kraju tova 22,11.
Abstract
Respiratory diseases of cattle are considered to be the most frequent causes of health problems in now days cattle industry. Among all respiratory diseases the Bovine Respiratory Disease Complex - BRDC is the most significant. BRDC is manifested with severe inflammation of respiratory tract and lungs. The disease is caused by viruses, bacteria and stress factors. The major etiological agents of this disease are, however, the viruses especially accompanied with stress. Among many viruses the most significant role in BRDC is attributed to herpes virus type-1 (BHV-1), parainfluneca-3 virus (PI-3), the bovine respiratory syncytial virus (BRSV), bovine viral diarrhoea virus (BVDV) while less important are bovine adenoviruses and corona viruses. BRDC is common in our cattle industry mostly in intensive rearing of beef cattle. Ethiopathogenesis, clinical and pathological characteristics of BRDC are presented in our literature usually from the aspect of BHV-1 and BVDV infections. A small number of papers deal with the disease from the aspect of PI-3 and BRSV. Therefore the goal of this paper is to present BRDC outbreak, accompanied with PI-3 infection, in one bull calves fattening unit of industrial type (number of bull calves in one production cycle is 800 to 1200). The paper presents clinical signs, procedure for PI-3 virus isolation and bacteria detection in diseased beef cattle. In the paper is also presented the immune response in 30 beef cattle (from the stable where the infection occurred) on PI-3 virus. The immune response was determined through detection of specific antibodies to PI-3 at the time of occurrence of the disease and also at 3 and 6 weeks after diseases outbreak as well as at the end of fattening, i.e. 4 months after PI-3 infection. The geometric mean value of antibody titre against this virus was at the moment of disease occurrence 14.58, while in 3 and 6 weeks after outbreak it was 45.25 and 54.44, and at the end of fattening it was 22.11.
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