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Journal of Medical Biochemistry
2017, vol. 36, br. 4, str. 349-357
jezik rada: srpski
vrsta rada: izvorni naučni članak
objavljeno: 31/01/2020
PMC ID: PMC6294082
doi: 10.1515/jomb-2017-0015
Povezanost između dva česta polimorfizma vitamin d-vezujućeg proteina i rizika od koronarne arterijske bolesti - anamnestička studija
aShahid Beheshti University of Medical Sciences, School of Allied Medical Sciences, Department of Medical Laboratory Sciences, Tehran, Iran
bUniversal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran + Universal Scientific Education and Research Network (USERN), Cardiac Outcome Research and Education (CORE), Tehran, Iran
cTehran University of Medical Sciences, Endocrinology and Metabolism Clinical Sciences Institute, Osteoporosis Research Center, Tehran, Iran
dUniversity of Medical Sciences, Shahid Beheshti Faculty of Medicine, Department of Medical Genetics, Tehran, Iran
eTehran University of Medical Sciences, School of Medicine, Department of Biochemistry, Tehran, Iran
fIran University of Medical Sciences, Faculty of Medicine, Faculty of Medicine, Tehran, Iran

e-adresa: Shanaki_m@sbmu.ac.ir

Projekat

The present study was supported by a grant (1395-9-7181) from Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Sažetak

Uvod: Koronarna arterijska bolest (CAD) jedno je od najrasprostranjenijih hroničnih oboljenja. Vitamin D-vezujuci protein (VDBP) i njegovi genetski polimorfizmi predočeni su kao podložne komponente za CAD. Cilj ove studije bio je da se ispita povezanost između polimorfizama pojedinačnih nukleotida (SNPs) proteina VDBP -rs7041 i rs4588 i podložnosti CAD u populaciji Iranaca. Metode: Ukupno 143 muškarca sa CAD i 145 zdravih kontrolnih ispitanika odgovarajuceg uzrasta i pola podvrgnuto je genotipizaciji za polimorfizme -rs7041 i rs4588 pomocu metode lančane reakcije polimeraze odnosno polimorfizama dužine restrikcionih fragmenata (PCR-RFLP). Nivo 25(OH)D u serumu određen je pomocu kolorimetrijskog enzimskog imunoeseja na mikroploči. Rezultati: Otkrili smo značajnu povezanost između genotipa GG (rs7041) i CAD (p= 0,02, O R= 0,537 95% C I= 0,306-0,944). Sto se tiče polimorfizma rs4588, uočena je značajna razlika, pri čemu su genotip CA (P= 0,00032, or =2,578, 95% CI = 1,579-4,208) i alel A (P= 0,028, O R= 1,491, 95% CI = 1,043-2,132) bili značajno viši kod obolelih od CAD u poređenju s kontrolom. Uprkos nižim serumskim nivoima 25(OH)D kod pacijenata sa CAD, nije otkrivena značajna povezanost između ovih polimorfizama i koncentracija vita - mina D u serumu. Zaključak: Zaključili smo da polimorfizmi VDBP utiču na podložnost CAD kod iranskih muškaraca. Dakle, potrebne su dalje studije kako bi se razjasnila povezanost između fenotipova VDBP i njegovih nivoa u serumu i CAD.

Ključne reči

koronarna arterijska bolest; polimorfizam; vitamin D-vezujuci protein; 25(OH)D

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