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Hemijski pregled
2012, vol. 53, br. 1, str. 12-16
jezik rada: srpski
članak
Farmakološko dejstvo prirodnih imida
Univerzitet u Beogradu, Poljoprivredni fakultet


Sažetak

Heterociklični sistemi koji sadrže azot su veo- ma rasprostranjeni među alkaloidima i ispoljavaju različitu farmakološku aktivnost. Petočlani i šestočlani ciklični imidi su značajna bioaktivna jedinjenja koja deluju kao antagonisti androgenih receptora, antiinflamatorni agensi, anksiolitici, antivirotici, antibiotici i agensi koji sprečavaju razvoj različitih tumora. Iako se ova jedinjenja retko nalaze u prirodnim proizvodima, svi do sada izolovani imidi ispoljavaju farmakološku aktivnost, što ukazuje na njihov značaj kao potencijalnih farmakoterapeutika.

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