Metrika članka

  • citati u SCindeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[=>]
  • posete u poslednjih 30 dana:4
  • preuzimanja u poslednjih 30 dana:4
članak: 4 od 8  
Back povratak na rezultate
Scripta Medica
2019, vol. 50, br. 2, str. 82-88
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 13/08/2019
doi: 10.5937/scriptamed50-22278
Results of the kidney transplant programme at the University Clinical Centre of the Republic of Srpska from 2010 to 2018
(naslov ne postoji na srpskom)
aKlinički centar Republike Srpske, Klinika za unutrašnje bolesti, Banja Luka, Republika Srpska, BiH + Univerzitet u Banjoj Luci, Medicinski fakultet, Republika Srpska, BiH
bUniverzitet u Banjoj Luci, Medicinski fakultet, Republika Srpska, BiH + Klinički centar Republike Srpske, Banja Luka, Republika Srpska, BiH
cUniverzitet u Banjoj Luci, Medicinski fakultet, Republika Srpska, BiH + Klinički centar Republike Srpske, Služba za vaskularnu hirurgiju, Banja Luka, Republika Srpska, BiH
dKlinički centar Republike Srpske, Klinika za urologiju, Banja Luka, Republika Srpska, BiH + Klinički centar Republike Srpske, Služba za vaskularnu hirurgiju, Banja Luka, Republika Srpska, BiH
eUniverzitet u Banjoj Luci, Medicinski fakultet, Republika Srpska, BiH + Klinički centar Republike Srpske, Klinika za anesteziju i intenzivno liječenje, Banja Luka, Republika Srpska, BiH
fnema
gKlinički centar Republike Srpske, Klinika za anesteziju i intenzivno liječenje, Banja Luka, Republika Srpska, BiH
hKlinički centar Republike Srpske, Služba za vaskularnu hirurgiju, Banja Luka, Republika Srpska, BiH
iKlinički centar Republike Srpske, Centar za radioterapiju, Banja Luka, Republika Srpska, BiH
jKlinički centar Republike Srpske, Klinika za psihijatriju, Banja Luka, Republika Srpska, BiH
kKlinički centar Republike Srpske, Klinika za unutrašnje bolesti, Banja Luka, Republika Srpska, BiH
lKlinički centar Republike Srpske, Klinika za neurologiju, Banja Luka, Republika Srpska, BiH

e-adresa: grujicic-m@hotmail.com

Sažetak

(ne postoji na srpskom)
Background: Kidney transplantation is the best treatment for patients with end-stage renal disease (ESRD). The aim of the study was to show the results of kidney transplantation performed in the University Clinical Centre of the Republic of Srpska in the period 2010-2018. Methods: This was a retrospective, 8-year observational cross-sectional study. Studied endpoints were overall patient survival, as well as graft survival rate in kidney transplant recipients. Recipient's age, gender, induction immunosuppressive therapy, the underlying cause of ESRD, the dialysis modality and post-operative complications (surgical, medical, urinary tract infections, electrolyte imbalance, and graft rejection) and their influence on the patient and graft survival rates were monitored. Results: The 30 living-donor kidney transplantations were performed, 29 living-related donor and one living-unrelated donor renal transplantation. A total of 70% of kidney recipients were male, and 30% were female. The average age of patient was 34.43 ± 8.67 years. Induction immunosuppressive regimen was prescribed to 76.7% of transplanted patients. Graft rejection occurred in 5 patients (16.7%). The 1-year, 3-year, 5-year, and 8-year patients survival rates were 100%, 100%, 96.97% and 93.33%, respectively. The 1-, 3-, 5-, and 8-year graft survival rates were 100%, 96.97%, 93.33% and 86.67%, respectively. The current mean value of glomerular filtration rate (GFR) in 25 patients with functional graft was 81.8 ± 30.3 ml/min. There was a statistically significant difference in the graft survival rate in the group with urinary tract infections (UTIs) (66.66%) compared to a group without UTIs (100%). Overall patient survival was significantly lower in the group with graft rejection (60%) compared to the group without graft rejection (92%). Kidney graft survival rate and overall patient survival have not been significantly different in terms of the studied factors (recipient's age, gender, induction immunosuppressive treatment, underlying cause of ESRD, dialysis modality, surgical or medical complications, and electrolyte imbalance). Conclusion: The results of living-donor kidney transplantation performed in the University Clinical Center of the Republic of Srpska are good in comparison with the results obtained at other centres.

Ključne reči

kidney transplantation; living donor; graft survival rate; patient survival

Reference

Bašić-Jukić, N. (2013) It is possible to maintain the highest number of transplantation in Croatia in the long term?. Bantao J, 11: 49-49
Bodro, M., Sanclemente, G., Lipperheide, I., Allali, M., Marco, F., Bosch, J., Cofan, F., Ricart, M.J., Esforzado, N., Oppenheimer, F., Moreno, A., Cervera, C. (2015) Impact of urinary tract infections on short-term kidney graft outcome. Clinical Microbiology and Infection, 21(12): 1104.e1-1104.e8
Brunet, M., van Gelder, T., Åsberg, A., Haufroid, V., Hesselink, D.A., Langman, L., Lemaitre, F., Marquet, P., Seger, C., Shipkova, M., Vinks, A., Wallemacq, P., Wieland, E., Woillard, J.B. (2019) Therapeutic drug monitoring of tacrolimus-personalized therapy: Second consensus report. Therapeutic Drug Monitoring, 41(3): 261-307
Campbell, S.B., Hothersall, E., Preston, J., Brown, A.M., Hawley, C.M., Wall, D., Griffin, A.D., Isbel, N.M., Nicol, D.L., Johnson, D.W. (2003) Frequency and severity of acute rejection in liveversus cadaveric-donor renal transplants. Transplantation, 76(10): 1452-1457
Dávila, F.A., Luna, R.D., Pardo, R.D.A. (2015) Analysis of graftposttransplant renal survival. Revistas Colombiana de Nefrología, 2(2): 96-101
Gołębiewska, J.E., Dębska-Ślizień, A., Rutkowski, B. (2014) Urinary tract infections during the first year after renal transplantation: One center's experience and a review of the literature. Clinical Transplantation, 28(11): 1263-1270
Gondos, A., Döhler, B., Brenner, H., Opelz, G. (2013) Kidney graft survival in Europe and the United States: Strikingly different long-term outcomes. Transplantation, 95(2): 267-74
Jha, V., Garcia-Garcia, G., Iseki, K., Li, Z., Naicker, S., Plattner, B., Saran, R., Wang, A.Y., Yang, C. (2013) Chronic kidney disease: Global dimension and perspectives. Lancet, 382(9888): 260-272
Kandus, A., Buturović-Ponikvar, J., Mlinšek, G., Oblak, M., Arnol, M. (2016) Kidney Transplantation in Slovenia from 1970 to 2015. Therapeutic Apheresis and Dialysis, 20(3): 229-233
Laupacis, A., Keown, P., Pus, N., Krueger, H., Ferguson, B., Wong, C., Muirhead, N. (1996) A study of the quality of life and cost-utility of renal transplantation. Kidney International, 50(1): 235-242
Morales, J.M., Marcen, R., Del, C.D., Andres, A., Gonzalez-Molina, M., Oppenheimer, F., Seron, D., Gil-Vernet, S., Lampreave, I., Gainza, F.J., Valdes, F., Cabello, M., Anaya, F., Escuin, F., Arias, M., Pallardo, L., Bustamante, J. (2012) Risk factors for graft loss and mortality after renal transplantation according to recipient age: A prospective multicentre study. Nephrology Dialysis Transplantation, 27(suppl 4): iv39-iv46
Noppakun, K., Cosio, F.G., Dean, P.G., Taler, S.J., Wauters, R., Grande, J.P. (2011) Living Donor Age and Kidney Transplant Outcomes. American Journal of Transplantation, 11(6): 1279-1286
Russell, D.J., Beecroft, M.L., Ludwin, D., Churchill, D.N. (1992) The quality of life and cost utility of renal transplantationa prospective study. Transplantation, 54(4): 656-660
Schnuelle, P., Lorenz, D., Trede, M., van der Woude, F.J. (1998) Impact of renal cadaveric transplantation on survival in end-stage renal failure: evidence for reduced mo tality risk compared with hemodialysis during longterm follow-up. J Am Soc Nephrol, 9(11): 2135-2176
Spasovski, G., Busic, M., Raley, L., Pipero, P., Sarajlic, L., Popovic, A.S., Dzhaleva, T., Codreanu, I., Ratkovic, M.M., Popescu, I., Lausevic, M., Avsec, D., Ekberg, H., Ploeg, R., Delmonico, F. (2012) Current status of transplantation and organ donation in the Balkans: Could it be improved through the South-eastern Europe Health Network (SEEHN) initiative?. Nephrology Dialysis Transplantation, 27(4): 1319-1323
Tonelli, M., Wiebe, N., Knoll, G., Bello, A., Browne, S., Jadhav, D., Klarenbach, S., Gill, J. (2011) Systematic Review: Kidney Transplantation Compared with Dialysis in Clinically Relevant Outcomes. American Journal of Transplantation, 11(10): 2093-2109
Wolfe, R.A., Ashby, V.B., Milford, E.L., Ojo, A.O., Ettenger, R.E., Agodoa, L.Y.C., Held, P.J., Port, F.K. (1999) Comparison of Mortality in All Patients on Dialysis, Patients on Dialysis Awaiting Transplantation, and Recipients of a First Cadaveric Transplant. New England Journal of Medicine, 341(23): 1725-1730