Actions

Archive of Oncology
how to cite this article
share this article
Permalink

Metrics

  • citations in SCIndeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[]
  • visits in previous 30 days:5
  • full-text downloads in 30 days:3

Contents

article: 1 from 4  
Back back to result list
Archive of Oncology
2020, vol. 26, iss. 1, pp. 1-5
Distribution of histopathological types of thyroid tumors in 1999-2015 compared to 1966-1988 year period
Makazlieva Tanjaa, Vaskova Olivijaa, Nikolovska Aleksandrab, Velikj Stefanovska Vesnac
aUniversity of Saints Cyril and Methodius, Faculty of Medicine, Institute of Pathophysiology and Nuclear Medicine "Akademik Isak S. Tadzer", Skopje, Republic of North Macedonia
bClinical hospital Tetovo, Department of Oncology, Tetovo, Republic of North Macedonia
cUniversity of Saints Cyril and Methodius, Faculty of Medicine, Institute for Epidemiology and Biostatistics with Medical Informatics, Skopje, Republic of North Macedonia

email: tmakazlieva@gmail.com
Keywords: thyroid carcinomas; histopathological change; PTC/FTC ratio; periodicity
Abstract
Background: The most common thyroid tumors originate from the epithelial follicular cells. Etiology involved in the development of thyroid carcinoma is multifactorial, including external influences and genetic predisposition. Aim: The objective of our study was to analyze the distribution of the histopathological types of thyroid carcinoma during 1999-2015 year period, to evaluate papillary and follicular thyroid carcinoma ratio and to compare thyroid carcinoma types with the data from prior epidemiological study referring to the period from 1966 -1988. Methods: A retrospective analysis was performed. The trend for thyroid carcinoma cases was evaluated in the time period of 50 years. Percentages of different histopathological types of thyroid carcinoma were presented and papillary and follicular thyroid carcinoma ratio was calculated for the two evaluated periods. Results: A total number of 422 thyroid carcinoma patients were diagnosed in the 1999-2015 year period vs. 323 patients in the period from 1966-1988. Analysis revealed no statistically significant difference in histopathological types of thyroid carcinoma during 1999-2015 year period, but statistically significant difference was detected between the two analyzed periods with a significant increase of papillary and follicular thyroid carcinoma ratio (from 3.1 to 7.3), and a significant reduction of anaplastic thyroid carcinomas cases in the more recent evaluated period (1999-2015). Conclusion: The analysis of the fifty-year-period in population of North Macedonia showed an increase in number of thyroid carcinoma cases, especially papillary and reduction of follicular thyroid carcinoma and anaplastic thyroid carcinomas cases. Further, genetic profiling studies could be useful in evaluating possible mechanisms behind this shift in histopathology of the thyroid carcinomas.
References

al-Brahim N., Asa, S.L. (2006) Papillary thyroid carcinoma: An overview. Arch Pathol Lab Med, 130(7), 1057-1062, https://www.ncbi.nlm.nih.gov/pubmed/16831036

Bubenhofer, R., Hedinger, C. (1977) Thyroid neoplasms before and after the prophylactic supplementation of table salt with iodine. Schweiz Med Wochenschr, 107, 733-741

de Groot, L.J., Larsen, R.P., Hennemann, G. (1995) The thyroid and its diseases. Churchill Livingstone, December 12, 6th edition

Favus, M.J., Schneider, A.B., Stachura, M.E., Arnold, J.E., Ryo, Y.U., Pinsky, S.M., Colman, M., Arnold, M.J., Frohman, L.A. (1976) Thyroid cancer occurring as a late consequence of head-and-neck irradiation. New England Journal of Medicine, 294(19), 1019-1025

Fiore, A.P., Fuziwara, C.S., Kimura, E.T. (2009) High iodine concentration attenuates RET/PTC3 oncogene activation in thyroid follicular cells. Thyroid, 19(11), 1249-1256, https://www.ncbi.nlm.nih.gov/pubmed/19725779

Furukawa, K., Preston, D., Funamoto, S., Yonehara, S., Ito, M., Tokuoka, S., Sugiyama, H., Soda, M., Ozasa, K., Mabuchi, K. (2013) Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: 60 years after exposure. International Journal of Cancer, 132(5), 1222-1226, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910094

Girardi, F.M., Barra, M.B., Zettler, C.G. (2013) Variants of papillary thyroid carcinoma: Association with histopathological prognostic factors. Brazilian Journal of Otorhinolaryngology, 79(6), 738-744

Guan, H., Ji, M., Bao, R.M., Yu, H., Wang, Y., Hou, P., Zhang, Y., Shan, Z., Teng, W., Xing, M. (2009) Association of high iodine intake with the T1799A BRAF mutation in papillary thyroid cancer. J Clin Endocrinol Metab, 94(5), 1612-1617, https://academic.oup.com/jcem/article/94/5/1612/2598162

2

Haugen, B.R., Alexander, E.K., Bible, K.C., Doherty, G.M., Mandel, S.J., Nikiforov, Y.E., et al. (2016) American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid, 26(1), 1-133

Hodgson, N.C., Button, J., Solorzano, C.C. (2004) Thyroid cancer: Is the incidence still increasing?. Annals of Surgical Oncology, 11(12), 1093-1097, http://europepmc.org/abstract/med/15576834

Horn-Ross, P.L., Morris, J.S., Lee, M., West, D.W., Whittemore, A.S., McDougall, I.R. (2001) Iodine and thyroid cancer risk among women in a multiethnic population: The bay area thyroid cancer study. Cancer Epidemiol Biomarkers Prev, 10(9), 979-985

Karanfilski, B., Serafimov, N., Dolgova-Korubin, V., Tadzer, I., Shestakov, G.J., Simova, N. (1982) Klinichki i laboratoriski karakteristiki na karcinomot na tiroidnata zhlezda vo SR Makedonija. Prilozi, 3(2), 13-27

Karanfilski, B., Tadzer, I., Serafimov, N., Dolgova-Korubin, V., Loparska, S., Miceva-Ristevska, S., et al. (1990) Karcinom na tiroidnata zhlezda vo SR Makedonija. in: Maligni zaboluvanja: problemi i dilemi, Nauchen sobir, Bitola

1

Karanfilski, B., Bogdanova, V., Vaskova, O., Loparska, S., Miceva-Ristevska, S., Sestakov, G., Kuzmanovska, S., Kolevska, L. (2003) Correction of Iodine deficiency in Macedonia. Journal of Pediatric Endocrinology and Metabolism, 16(7), 1041-1045

Katoh, H., Yamashita, K., Enomoto, T., Masahiko, W. (2015) Classification and general considerations of thyroid cancer. Ann Clin Pathol, 3(1), 1045-1054

Kebebew, E., Greenspan, F.S., Clark, O.H., Woeber, K.A., McMillan, A. (2005) Anaplastic thyroid carcinoma, treatment outcome and prognostic factors. Cancer, 103(7), 1330-1335, https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.20936

Kimura, T., van Keymeulen, A., Golstein, J., Fusco, A., Dumont, J.E., Roger, P.P. (2001) Regulation of thyroid cell proliferation by TSH and other factors: A critical evaluation of in vitro models. Endocrine Reviews, 22(5), 631-656, https://academic.oup.com/edrv/article/22/5/631/2424232

Kini, H., Rau, A.R., Augustine, A., Nirupama, M., Gupta, S. (2012) Poorly differentiated (insular) thyroid carcinoma arising in a long-standing colloid goitre: A cytological dilemma. Journal of Cytology, 29(1), 97-99, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307470

Knobel, M., Medeiros-Neto, G. (2007) Relevance of iodine intake as a reputed predisposing factor for thyroid cancer. Arquivos Brasileiros de Endocrinologia & Metabologia, 51(5), 701-712

1

La, V.C., Malvezzi, M., Bosetti, C., Garavello, W., Bertuccio, P., Levi, F., Negri, E. (2015) Thyroid cancer mortality and incidence: A global overview. International Journal of Cancer, 136(9), 2187-2195

Lam, K.A. (2017) Pathology of endocrine tumors update: World health organization new classification 2017-other thyroid tumors. AJSP: Reviews & Reports, 22(4), 209-216

Li, V.V.A. (2011) Papillary thyroid carcinoma: An update. Modern Pathology, 24(S2), S1-S9, https://www.nature.com/articles/modpathol2010129

Lloyd, R.V., Buehler, D., Khanafshar, E. (2011) Papillary thyroid carcinoma variants. Head and Neck Pathology, 5(1), 51-56, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037461

Makazlieva, T., Vaskova, O., Majstorov, V. (2016) Etiopathogenesis of differentiated thyroid carcinomas. Open Access Macedonian Journal of Medical Sciences, 4(3), 517-522, http://www.mjms.mk/Online/doi/OAMJMS2016_086Abstract.htm

Morris, L.G.T., Sikora, A.G., Tosteson, T.D., Davies, L. (2013) The increasing incidence of thyroid cancer: The influence of access to care. Thyroid, 23(7), 885-891, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704124

Nagaiah, G., Hossain, A., Mooney, C.J., Parmentier, J., Remick, S.C. (2011) Anaplastic thyroid cancer: A review of epidemiology, pathogenesis, and treatment. Journal of Oncology, 2011:542358, https://www.ncbi.nlm.nih.gov/pubmed/21772843

Refetoff, S., Harrison, J., Karanfilski, B.T., Kaplan, E.L., de Groot, L.J., Bekerman, C.J. (1975) Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood. New England Journal of Medicine, 292(4), 171-175

Schlumberger, M., Pacini, F., Tutle, R.M. (2015) Thyroid tumors. Paris: Institute Medico-Educatif, 4th edition

Scopa, C.D. (2004) Histopathology of thyroid tumors: An overview. Hormones, 3(2), 100-110, http://www.hormones.gr/89/article/article.html

Sobrinho-Simões, M., Eloy, C., Magalhães, J.C., Lobo, C., Amaro, T. (2011) Follicular thyroid carcinoma. Modern Pathology, 24(S2), S10-S18

Tucker, M.A., Jones, P.H., Boice, J.D., Robison, L.L., Stone, B.J., Stovall, M., Jenkin, R.D., Lubin, J.H., Baum, E.S., Siegel, S.E., The Late Effects Study Group (1991) Therapeutic radiation at a young age is linked to secondary thyroid cancer. Cancer Res, 51(11), 2885-2888

Vaskova, O., Kuzmanovska, S., Josifovska, T., Bogdanovska, A., Majstorov, V., Zdravkovska, M., et al. (2005) Thyroid malignomas before and after correction of mild iodine deficit. in: Radioactive isotopes in clinical medicine and research 27th International Symposium, Bad Gastein, Austria, Nuklearmedizin, 6

Williams, E.D., Doniach, I., Bjarnason, O., Michie, W. (1977) Thyroid cancer in an iodide rich area: A histopathological study. Cancer, 39(1), 215-222

Zimmermann, M.B., Galetti, V. (2015) Iodine intake as a risk factor for thyroid cancer: A comprehensive review of animal and human studies. Thyroid Research, 8:8, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490680
   

About

article language: English
document type: Original Scientific Paper
DOI: 10.2298/AOO190402005M
published in SCIndeks: 30/11/2019
peer review method: single-blind
Creative Commons License 4.0

Related records

No related records