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2020, vol. 26, iss. 1, pp. 1-5
Distribution of histopathological types of thyroid tumors in 1999-2015 compared to 1966-1988 year period
aUniversity of Saints Cyril and Methodius, Faculty of Medicine, Institute of Pathophysiology and Nuclear Medicine "Akademik Isak S. Tadzer", Skopje, Republic of North Macedonia
bClinical hospital Tetovo, Department of Oncology, Tetovo, Republic of North Macedonia
cUniversity of Saints Cyril and Methodius, Faculty of Medicine, Institute for Epidemiology and Biostatistics with Medical Informatics, Skopje, Republic of North Macedonia
Keywords: thyroid carcinomas; histopathological change; PTC/FTC ratio; periodicity
Background: The most common thyroid tumors originate from the epithelial follicular cells. Etiology involved in the development of thyroid carcinoma is multifactorial, including external influences and genetic predisposition. Aim: The objective of our study was to analyze the distribution of the histopathological types of thyroid carcinoma during 1999-2015 year period, to evaluate papillary and follicular thyroid carcinoma ratio and to compare thyroid carcinoma types with the data from prior epidemiological study referring to the period from 1966 -1988. Methods: A retrospective analysis was performed. The trend for thyroid carcinoma cases was evaluated in the time period of 50 years. Percentages of different histopathological types of thyroid carcinoma were presented and papillary and follicular thyroid carcinoma ratio was calculated for the two evaluated periods. Results: A total number of 422 thyroid carcinoma patients were diagnosed in the 1999-2015 year period vs. 323 patients in the period from 1966-1988. Analysis revealed no statistically significant difference in histopathological types of thyroid carcinoma during 1999-2015 year period, but statistically significant difference was detected between the two analyzed periods with a significant increase of papillary and follicular thyroid carcinoma ratio (from 3.1 to 7.3), and a significant reduction of anaplastic thyroid carcinomas cases in the more recent evaluated period (1999-2015). Conclusion: The analysis of the fifty-year-period in population of North Macedonia showed an increase in number of thyroid carcinoma cases, especially papillary and reduction of follicular thyroid carcinoma and anaplastic thyroid carcinomas cases. Further, genetic profiling studies could be useful in evaluating possible mechanisms behind this shift in histopathology of the thyroid carcinomas.
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article language: English
document type: Original Scientific Paper
DOI: 10.2298/AOO190402005M
published in SCIndeks: 30/11/2019
peer review method: single-blind
Creative Commons License 4.0

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