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2020, vol. 26, br. 1, str. 6-9
Epidemiological and pathological characteristics of postsurgical cases of invasive breast cancer among ethnicities of Iran in 2018: A single center cross-sectional study
(naslov ne postoji na srpskom)
aIran University of Medical Sciences, Firoozgar Clinical Research Development Center (FCRDC), Department of Surgery, Tehran, Iran + Iran University of Medical Sciences, Institute of Endocrinology and Metabolism, Pediatric Growth and Development Research Center, Tehran, Iran
bIran University of Medical Sciences, Student Research Committee, Tehran, Iran + Iran University of Medical Sciences, Institute of Endocrinology and Metabolism, Pediatric Growth and Development Research Center, Tehran, Iran
cIran University of Medical Sciences, Institute of Endocrinology and Metabolism, Pediatric Growth and Development Research Center, Tehran, Iran
dIran University of Medical Sciences, Firoozgar Clinical Research Development Center (FCRDC), Department of Pathology, Tehran, Iran
eLorestan University of Medical Sciences, Social Determinants of Health Research Center, Khorramabad, Iran

e-adresadr.anbari@gmail.com
Ključne reči: breast cancer; estrogen receptor; HER2; triple negative; pathology; Iran
Sažetak
(ne postoji na srpskom)
Background: Present study aimed to investigate immunohistochemical parameters in post-surgical cases of invasive breast cancer. Methods: In this single center cross-sectional study we investigated ethnicity, familial history, type of cancer, stage of cancer, lymph node positivity, bilateral involvement, metastasis and immunohistochemical parameters (estrogen and progesterone receptor, human epidermal growth factor receptor 2, as well as frequency of triple positive and triple negative patients merely based on immunohistochemical parameters). Results: Frequency of positive familial history was 27.42% (16.31-38.52%). Lymph node involvement was detected in 55.93% (43.26-68.60%) of the cases. Frequency of positive HER2 was 38.60% (25.96-51.23%). There were 17.54% (7.67-27.42%) of triple positive and 7.02% (0.39-13.65%) of triple negative cases. The most common stage at the time of diagnosis was stage 3 with 43.33% (30.79-55.87%) frequency. In Lur/Lak population higher frequency of positive HER2 cases was detected whereas in Mazani population frequency of positive HER2 cases was low (p=0.0291). Conclusions: These results could contribute to understanding of breast cancer patterns among different ethnicities. In order to draw clear conclusion future investigations have to be done in several health centers, for longer time periods and with larger number of patients.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/AOO190626007S
objavljen u SCIndeksu: 30.11.2019.
metod recenzije: jednostruko anoniman
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