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Srpski arhiv za celokupno lekarstvo
2019, vol. 147, iss. 9-10, pp. 571-577
article language: English
document type: Original Paper
published on: 16/11/2019
doi: 10.2298/SARH190204031J
Surgical treatment for breast tumors in children
aUniversity of Novi Sad, Faculty of Medicine, Institute for Child and Youth Health Care of Vojvodina + University of Novi Sad, Faculty of Medicine
bUniversity of Novi Sad, Faculty of Medicine + Oncology Institute of Vojvodina, Sremska Kamenica



Introduction/Objective Fibroadenoma, often called "breast mice tumors" due to their mobility, are the most common breast tumors in pediatric population. Considering that some tumors have a potential for rapid growth, breast tissue damage, and that an ideal diagnostic tool has yet to be found, complete mass extirpation might be the treatment of choice. The aim of the study was to present our clinical experience in treating children with breast masses. Methods A retrospective review (2011-2018) of patients treated for breast tumors at the Institute for Child and Youth Health Care of Vojvodina in Novi Sad was conducted. Results In this study 29 girls (mean age 15.8 ± 1.8) were included. The majority of masses were located in the upper outer (27.6%) or lower inner (24.1%) breast quadrant. The mean mass diameter was 39.7 mm. It has been observed that the mean mass diameter in the group of girls with positive family history for breast diseases was significantly lower (p < 0.05) than in those with negative family history (27.5 vs. 43.2 mm). There were no proven malignant tumors and all tumors have been completely extirpated. The mean postoperative stay was 1.5 ± 1.02 days. Conclusion An appropriate radical operative technique dependent on mass size and localization is still the "gold standard" for treating breast masses in pediatric patients. Cooperation with experts in the field of oncologic breast surgery enables implementing these operative techniques in clinical practice of pediatric surgeons.


breast fibroadenoma; phylloid breast tumor; surgery; children


Ahmed, S., Tate, J., Thrift-Perry, M., Wait, S. (2018) Barriers and opportunities in genetic testing for BRCA gene mutations in Europe: A strategic policy response to support women and families at risk for breast cancer. J Glob Oncol, 4(2)
Bhatia, S., Robinson, L., Oberlin, O., Greenberg, M., Bunin, G., Fossatibellani, F. (1996) Breast cancer and other second neoplasms after childhood Hodgkin's disease. N Engl J Med, 334(12), 745-751
Cerrato, F., Labow, B. (2013) Diagnosis and management of fibroadenomas in the adolescent breast. Semin Plast Surg, 27(1), 23-25
Cucinotta, M., Cistaro, A. (2014) Phylloid tumor of the breast. in: Cistaro A. [ed.] Atlas of PET/CT in Pediatric Patients, Milano: Springer
Gao, Y., Saksena, M., Brachtel, E., ter Meulen, D. (2015) How to approach breast lesions in children and adolescents. Eur J Radiol, 84(7), 1350-1364
Gatta, G., Iaselli, F., Parlato, V., di Grezia, G., Grassi, R., Rotondo, A. (2011) Differential diagnosis between fi broadenoma, giant fi broadenoma and phyllodes tumour: Sonographic features and core needle biopsy. Radiol Med, 116(6), 905-918
Greenberg, R., Skornick, Y., Kaplan, O. (1998) Management of breast fibroadenomas. J Gen Intern Med, 13(9), 640-645
Gunasekaran, G., Naik, D., Sharma, S., Bhandari, V., Mandal, A.K., Rajput, D. (2014) Recurrent phyllodes tumor of the breast transforming to a fibrosarcoma. Int Surg J, 1(3), 173-176
Jang, J.H., Choi, M.Y., Lee, S.K., Kim, S., Kim, J., Lee, J., et al. (2012) Clinicopathologic risk factors for the local recurrence of phyllodes tumors of the breast. Ann Surg Oncol, 19(8), 2612-2617
Kaneda, H., Mack, J., Kasales, C., Schetter, S. (2013) Pediatric and adolescent breast masses: A review of pathophysiology, imaging, diagnosis, and treatment. AJR Am J Roentgenol, 200(2), 204-212
Kennedy, R., Boughey, J. (2013) Management of pediatric and adolescent breast masses. Semin Plast Surg, 27(1), 19-22
Kuijper, A., Mommers, E., Wall, E., Diest, P. (2001) Histopathology of fibroadenoma of the breast. Am J Clin Pathol, 115(5), 736-742
Lee, M., Soltanian, M.T. (2015) Breast fibroadenomas in adolescents: Current perspectives. Adolesc Health Med Ther, 6, 159-163
Lim, W.K., Ong, C.K., Tan, J., Thike, A.A., Ng, Y.C.C., Rajasegaran, V., et al. (2014) Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. Nat Genet, 46(8), 877-880
Mavaddat, N., Pharoah, P., Michaidiolu, K., Tyrer, J., Brook, M., Bolla, M. (2015) Prediction of breast cancer risk based on profiling with common genetic variants. J Natl Cancer Inst, 107(5)
Mercato-Matos, J., Matthew-Onabanjo, A., Shaw, L. (2017) RUNX1 and breast cancer. Oncotarget, 8(23), 36934-36935
Muller, K.E., Tafe, L.J., Abreu, F.B., Peterson, J.D., Wells, W.A., Barth, R.J., et al. (2015) Benign phyllodes tumor of the breast recurring as a malignant phyllodes tumor and spindle cell metaplastic carcinoma. Hum Pathol, 46(2), 327-333
Ng, W., Mrad, A., Beown, M. (2011) Juvenile fibroadenoma of the breast: Treatment and literature review. Can J Plast Surg, 19(3), 105-107
Pinto, J., Aguiar, A.T., Duarte, H., Vilaverde, F., Rodrigues, A., Krug, J.L. (2014) Simple and complex fibroadenomas: Are there any distinguishing sonographic features. J Ultrasound Med, 33(3), 415-419
Sanders, L.M., Sharma, P., El-Madany, M., King, A.B., Goodman, K.S., Sanders, A.E. (2018) Clinical breast concerns in low-risk pediatric patients: Practice review with proposed recommendations. Pediatr Radiol, 48(2), 186-195
Sharma, B.B., Bhardwaj, N., Dewan, S., Aziz, M.R. (2017) Adolescent fibroadenoma (Breast 'Mouse'): Role of radiology in assisting diagnosis: A case report. EJMCR, 1(1), 5-9
Sherwani, A.M. (2014) Comparison of management and treatment options for recurrent breast fibroadenomas in adolescent females. BS: Boston University,
Siegel, M., Chung, E. (2017) Breast masses in children and adolescents. Appl Radiol, 46(9), 12-17
Silwal-Pandit, L., Moen, V.H.K., Chin, S.F., Rueda, O., McKinney, S., Osako, T., et al. (2014) TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance. Clin Cancer Res, 20(13), 1-12
Sosin, M., Pulcrano, M., Feldman, E., Patel, K., Nahabedian, M., Weisller, J. (2015) Giant juvenile fibroadenoma: A systematic review with diagnostic and treatment recommendations. Gland Surg, 4(4), 312-321
Stehr, K.G., Lebeau, A., Stehr, M., Grantzow, R. (2004) Fibroadenoma of the breast in an 11-year-old girl. Eur J Pediatr Surg, 14(1), 56-59
Tan, P.H., Thike, A.A., Tan, W.J., Thu, M.M., Busmanis, I., Li, H. (2012) Predicting clinical behaviour of breast phyllodes tumours: A nomogram based on histological criteria and surgical margins. J Clin Pathol, 65(1), 69-76
Thuruthiyath, N., Das, P.C., Avabratha, S., Mascarenhas, V., Marla, N. (2012) Giant fibroadenoma of breast in an adolescent girl. Oman Med J, 27(4), 314-315
Zhang, Y., Kleer, C.G. (2016) Phyllodes tumor of the breast histopathologic features, differential diagnosis, and molecular/genetic updates. Arch Pathol Lab Med, 140(7), 665-671
Zhang, Y., Walsh, M., Wu, G., Edmonson, M., Gruber, T., Easton, J. (2015) Germline mutations in predisposition genes in pediatric cancer. N Engl J Med, 373, 2336-2346