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Acta medica Medianae
2019, vol. 58, br. 2, str. 126-134
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 09/09/2019
doi: 10.5633/amm.2019.0220
Creative Commons License 4.0
Radiomorfometrijska analiza hipofize čoveka u procesu starenja
aUniverzitet u Nišu, Medicinski fakultet + Univerzitet u Nišu, Medicinski fakultet, Katedra Anatomija
bKlinički centar Niš, Centar za radiologiju
cUniverzitet u Nišu, Medicinski fakultet
dUniverzitet u Nišu, Medicinski fakultet, Katedra Anatomija

e-adresa: sonjasgirl@gmail.com

Sažetak

Tokom života postoje značajne promene u funkcionisanju hipotalamo-hipofizarne ose i ostalih endokrinih žlezdi u organizmu, što utiče na unutrašnju i spoljašnju morfologiju same žlezde. Takođe, veliki broj patoloških stanja pokazuje promenu u volumenu hipofize. Poznavanje dimenzija i volumena hipofize veoma je značajno za dijagnostiku i prognozu bolesti hipofize. Cilj našeg istraživanja bio je izvršiti morfometrijsku analizu hipofize osoba različite starosti i različitog pola. Naše istraživanje predstavlja retrospektivnu studiju koja obuhvata 144 ispitanika (60 muškaraca (41,6 %) i 84 žene (58,3 %)), starosti od 20 do 80 godina, koji su upućeni na pregled endokranijuma na magnetnoj rezonanci (MR). Ispitanici su podeljeni na osnovu godina starosti na: I grupu (20-39 godina), II grupu (40-59 godina) i III grupu (60-80 godina). Merena su tri dijametra hipofize: anteroposteriorni (AP), latero-lateralni (LL) i kranio-kaudalni (KK). Zapremina hipofize (V) izračunavana je na osnovu formule V = AP x LL x KK/2. U našem radu dobijena je statistički značajna razlika za parametre AP-H (p < 0,037) i AP-A (p < 0,04) kod bolesnika I i II grupe. Takođe, kod parametra KK postoji statistički značajna razlika između I i III starosne grupe (p < 0,031). Kod ispitanika ženskog pola vrednost AP-H parametra iznosi 10,99 ± 1,16 mm, dok kod ispitanika muškog pola iznosi 10,43 ± 1,31 mm, što ukazuje na postojanje statistički značajne razlike AP-H parametra u odnosu na pol (p < 0,008). AP-N paremetar kod ispitanika ženskog pola iznosi 2,21 ± 0,72 mm, a kod ispitanika muškog pola 1,91 ± 0,67 mm, što takođe ukazuje na postojanje statisti-čki značajne razlike AP-N parametra u odnosu na pol (p < 0,012). Vrednosti parametara hipofize dobijene u našem radu ukazuju na normalne vrednosti dimenzija hipofize u srpskoj populaciji. Tokom života dolazi do promene morfologije hipofize u smislu povećanja AP dimenzije, a smanjenja KK dimenzije. Takođe su utvrđene razlike prema polu što sve zajedno treba imati na umu prilikom ispitivanja patoloških promena ili povrede hipofize.

Ključne reči

hipofiza; Mr; radiomorfometrijska analiza; starenje; zapremina

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