Metrika

  • citati u SCIndeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:2
  • preuzimanja u poslednjih 30 dana:1

Sadržaj

članak: 4 od 16  
Back povratak na rezultate
2021, vol. 12, br. 2, str. 160-169
Povezanost metaboličkog sindroma i homocisteinemije kod ishemijskog moždanog udara
aUniverzitet u Banjoj Luci, Medicinski fakultet, Katedra za patološku fiziologiju, Republika Srpska, BiH
bUniverzitet u Istočnom Sarajevu, Medicinski fakultet, Foča, Republika Srpska, BiH

e-adresamilorad.vujnic@med.unibl.org
Sažetak
Uvod. Moždani udar predstavlja jedan od vodećih uzroka morbiditeta i mortaliteta širom svijeta. Povezanost između metaboličkog sindroma (MetS) i homocisteinemije (Hcy) kao faktora rizika za ishemijski moždani udar (IMU) nije dovoljno rasvijetljena. Cilj istraživanja je bio da se ustanovi učestalost MetS, nivo Hcy u serumu i učestalost hiperhomocisteinemije (HHcy), kao i njihova međusobna povezanost kod oboljelih od IMU. Metode. Istraživanjem su bila obuhvaćena 53 ispitanika na rehabilitaciji nakon IMU i 40 ispitanika kontrolne grupe koji su bili na rehabilitaciji zbog bola u leđima starosti od 50 do 70 godina. Dijagnoza IMU je postavljena uvidom u medicinsku dokumentaciju i svi bolesnici su morali imati dijagnozu potvrđenu "imaging" metodom (KT ili MR endokranijuma). Svim ispitanicima kontrolne grupe isključeno je postojanje ranijih moždanih i srčanih udara, angine pektoris i periferne vaskularne bolesti. Dijagnoza MetS je postavljena na osnovu usaglašenih, zajedničkih kriterijuma iz 2009. godine. Rezultati. Učestalost MetS je bila značajno viša kod bolesnika sa moždanim udarom u odnosu na kontrolnu grupu (88,7% vs. 70,0%, p<0,05). Nivo Hcy u serumu i učestalost HHcy su bili viši kod bolesnika sa moždanim udarom u odnosu na kontrolnu grupu (15,0±5,50 µmol/L vs. 11,2±2,51 µmol/L, p<0,01 i 39,2% vs. 11,4%, p<0,01). Pacijenti sa IMU i MetS imali su veću učestalost HHcy u odnosu na one bez MetS (42,2% vs. 16,7%, p<0,05) i njena učestalost je rasla sa porastom broja pojedinačnih komponenti sindroma (11,1% kod pacijenata sa 3 komponente, 36,8% kod pacijenata sa 4 komponente i 64,7% kod pacijeneta sa 5 komponenti, p<0,05). Nivo Hcy u serumu je bio u pozitivnoj korelaciji sa nivoom triglicerida u serumu. Zaključak. Naši rezultati sugerišu da MetS i Hcy predstavljaju značajne faktore rizika za nastanak IMU. Čini se da postoji povezanost između ovih faktora rizika u patogenezi IMU, ali su potrebna daljnja istraživanja da bi se potvrdila ova hipoteza.
Reference
*** (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment in High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA, 285: 2486-2497
Abbasi, F., Facchini, F., Humphreys, M.H., Reaven, G.M. (1999) Plasma Homocysteine Concentrations in Healthy Volunteers Are Not Related to Differences in Insulin-Mediated Glucose Disposal. Atherosclerosis, 146(1): 175-178
Alberti, K.G.M.M., Eckel, R.H., Grundy, S.M., Zimmet, P.Z., Cleeman, J.I., Donato, K.A., et al. (2009) Harmonizing the Metabolic Syndrome. A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; Internati. Circulation, 120(16): 1640-1645
Azarpazhooh, M.R., Andalibi, M.S.S., Hackam, D.G., Spence, J.D. (2020) Interaction of Smoking, Hyperhomocysteinemia and Metabolic Syndrome with Carotid Atherosclerosis: A Cross Sectional Study in 972 Non-Diabetic Patients. Nutrition, 79-80
Bellia, C., Bivona, G., Scazzone, C., Ciaccio, M. (2007) Association Between Homocysteinemia and Metabolic Syndrome in Patients with Cardiovascular Disease. Ther Clin Risk Manag, 3(6): 999-1001
Chrysant, S.G., Chrysant, G.S. (2018) The Current Status of Homocysteine as a Risk Factor for Cardiovascular Disease: A Mini Review. Expert Rev Cardiovasc Ther, 16(8): 559-565
de Farias, C.P.R., Kinra, S., D'almeida, V., Assis, A.M.O. (2017) Serum Homocysteine and Cysteine Levels and Changes in the Lipid Profile of Children and Adolescents Over a 12-Month Follow-Up Period. Clinical Nutrition ESPEN, 21: 13-19
Fallon, U.B., Virtamo, J., Young, I., McMaster, D., Shlomo, Y.B., Wood, N., et al. (2003) Homocysteine and Cerebral Infarction in Finnish Male Smokers. Stroke, 34(6): 1359-1363
Frauscher, G., Karnaukhova, E., Muehl, A., Hoeger, H., Lubec, B. (1995) Oral Administration of Homocysteine Leads to Increased Plasma Triglycerides and Homocysteic Acid Additional Mechanisms in Homocysteine Induced Endothelial Damage?. Life Sci, 57(8): 813-817
Fu, S., Yao, Y., Zhao, Y., Luan, F. (2018) Relationships of Hyperhomocysteinemia and Hyperuricemia with Metabolic Syndrome and Renal Function in Chinese Centenarians. Front Endocrinol, Lausanne, 9: 502-502
Ganguly, P., Alam, S.F. (2015) Role of Homocysteine in the Development of Cardiovascular Disease. Nutr J, 14: 6-6
Godsland, I.F., Rosankiewich, J.R., Proudler, A.J., Johnston, D.G. (2001) Plasma Total Homocysteine Concentrations Are Unrelated to Insulin Sensitivity and Components of the Metabolic Syndrome in Healthy Men. J Clin Endocrinol Metab, 86(2): 719-723
Grundy, S.M. (2016) Metabolic Syndrome Update. Trends Cardiovasc Med, 26(4): 364-373
Kim, J., Pyo, S., Yoon, D.W., Lee, S., Lim, J., Heo, J.S., et al. (2018) The Co-Existence of Elevated High Sensitivity C-Reactive Protein and Homocysteine Levels Is Associated with Increased Risk of Metabolic Syndrome: A 6-Year Follow-Up Study. PloS One, 13(10): e0206157
Li, X., Li, X., Fang, F., Fu, X., Lin, H., Gao, Q. (2017) Is Metabolic Syndrome Associated with the Risk of Recurrent Stroke: A Meta-Analysis of Cohort Studies. J Stroke Cerebrovasc Dis, 26(12): 2700-2705
Liu, C., Sun, X., Lin, H., Zheng, R., Ruan, L., Sun, Z., et al. (2018) Associations of Hyperhomocysteinemia and Metabolic Syndrome with Early Carotid Artery Atherosclerosis: A Cross-Sectional Study in Middle-Aged Chinese Population. Nutrition, 53: 115-119
Meigs, J.B., Jacques, P.F., Selhub, J., de Singer,, Nathan, D.M., Rifai, N., et al. (2001) Fasting Plasma Homocysteine Levels in Insulin Resistance Syndrome: The Framingham Offspring Study. Diabetes Care, 24(8): 1403-1410
Miller, C.M. (2017) Stroke Epidemiology. u: Lapchak P.; Yang G.Y. [ur.] Translational Research in Stroke: Translational Medicine Research, Singapore: Springer
Momin, M., Jia, J., Fan, F., Li, J., Dou, J., Chen, D., et al. (2017) Relationship Between Plasma Homocysteine Level and Lipid Profiles in a Community-Based Chinese Population. Lipids Health Dis, 16(1): 54-54
Mozaffarian, D., Benjamin, E.J., Go, A.S., Donna, K.A., Blaha, M.J., Cushman, M., et al. (2016) Heart Disease and Stroke Statistics 2016, Update: A Report from the American Heart Association. Circulation, 133(4): e38-360
Olijhoek, J.K., van der Graaf, Y., Banga, J.D., Algra, A., Rabelink, T.J., Visseren, F.L.J. (2004) The Metabolic Syndrome Is Associated with Advanced Vascular Damage in Patients with Coronary Heart Disease, Stroke, Peripheral Arterial Disease or Abdominal Aortic Aneurysm. Eur Heart J, 25(4): 342-348
Patterson, S., Flatt, P.R., Brennan, L., Newsholme, P., McClenaghan, N.H. (2006) Detrimental Actions of Metabolic Syndrome Risk Factor, Homocysteine, on Pancreatic B-Cell Glucose Metabolism and Insulin Secretion. J Endocrinol, 189(2): 301-310
Piazzolla, G., Candigliota, M., Fanelli, M., Castrovilli, A., Berardi, E., Antonica, G., et al. (2019) Hyperhomocysteinemia Is an Independent Risk Factor of Atherosclerosis in Patients with Metabolic Syndrome. Diabetol Metab Syndr, 11: 87-87
Reffat, S., Sheikh, B., Fath-El-bab, M., Gabal, A.M., Ibrahim, M., Hassan, A., et al. (2010) Metabolic Syndrome in Acute Stroke Patients in Al-Madinah Al-Munawarah Kingdom of Saudi Arabia. Journal of Medicine and Biomedical Sciences, 1: 2078-2083
Rosolova, H., Šimon, J., Mayer, O., Racek, J., Dierze, T., Jacobsen, D.W. (2002) Unexpected Inverse Relationship Between Insulin Resistance and Serum Homocysteine in Healthy Subjects. Physiol Res, 51(1): 93-98
Serdarević, N., Begić, L., Mulaomerović-Softić, A. (2011) The Concentration of Homocysteine in Patients After Ischemic Brain Stroke and Vascular Dementia. Journal of Health Sciences, 1(1): 27-32
Setola, E., Monti, L.D., Galluccio, E., Palloshi, A., Fragasso, G., Paroni, R., et al. (2004) Insulin Resistance and Endothelial Function Are Improved After Folate and Vitamin B12 Therapy in Patients with Metabolic Syndrome: Relationship Between Homocysteine Levels and Hyperinsulinemia. Eur J Endocrinol, 151(4): 483-489
Shi, Z., Liu, S., Guan, Y., Zhang, M., Lu, H., Yue, W., et al. (2018) Changes in Total Homocysteine Levels After Acute Stroke and Recurrence of Stroke. Sci Rep, 8(1): 6993-6993
Sreckovic, B., Sreckovic, V.D., Soldatovic, I., Colak, E., Sumarac-Dumanovic, M., Janeski, H., et al. (2017) Homocysteine Is a Marker for Metabolic Syndrome and Atherosclerosis. Diabetes Metab Syndr, 11(3): 179-182
Srećković, B., Soldatovic, I., Colak, E., Mrdovic, I., Sumarac-Dumanovic, M., Janeski, H., et al. (2018) Homocysteine Is the Confounding Factor of Metabolic Syndrome-Confirmed by siMS score. Drug Metab Pers Ther, 33(2): 99-103
Uysal, O., Arikan, E., Cakir, B. (2005) Plasma Total Homocysteine Level and Its Association with Carotid Intima-Media Thickness in Obesity. J Endocrinol Invest, 28(1): 928-934
Vayá, A., Rivera, L., Hernández-Mijares, A., de la Fuente, M., Solá, E., Romagnoli, M., et al. (2012) Homocysteine Levels in Morbidly Obese Patients: Its Association with Waist Circumference and Insulin Resistance. Clin Hemorheol Microcirc, 52(1): 49-56
Vujnic, M., Peric, S., Popovic, S., Raseta, N., Ralic, V., Dobricic, V., et al. (2015) Metabolic Syndrome in Patients with Myotonic Dystrophy Type 1. Muscle Nerve, 52(2): 273-277
Wang, J., You, D., Wang, H., Yang, Y., Zhang, D., Lv, J., et al. (2021) Association Between Homocysteine and Obesity: A Meta-Analysis. J Evid Based Med, 14(3): 208-217
Zhang, Z., Fang, X., Hua, Y., Liu, B., Ji, X., Tang, Z., et al. (2016) Combined Effect of Hyperhomocysteinemia and Hypertension on the Presence of Early Carotid Artery Atherosclerosis. J Stroke Cerebrovas Dis, 25(5): 1254-1262
 

O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.5937/BII2102160V
primljen: 15.08.2021.
prihvaćen: 06.12.2021.
objavljen u SCIndeksu: 25.04.2022.
Creative Commons License 4.0

Povezani članci

Nema povezanih članaka