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2021, vol. 12, br. 2, str. 193-203
Značaj polimorfizama glutation transferaza za nastanak dijabetične nefropatije
aUniverzitetska bolnica Foča, Republika Srpska, BiH
bUniverzitet u Istočnom Sarajevu, Medicinski fakultet, Foča, Republika Srpska, BiH

e-adresadraganatosovic@yahoo.com
Ključne reči: dijabetes; dijabetesna nefropatija; polimorfizam glutation transferaza
Sažetak
Genetički faktori i faktori sredine imaju važnu ulogu u nastanku dijabetes melitusa tip 2 (DM2) i njegovih komplikacija. Dijabetesna nefropatija (DN) jedna je od najčešćih mikroangiopatskih hroničnih komplikacija dijabetesa. Oksidativni stres nastaje u uslovima povećane produkcije slobodnih radikala i/ili smanjenja aktivnosti enzima antioksidativne zaštite i predstavlja bitnu kariku u složenom mehanizmu nastanka dijabetičnih vaskularnih promjena. Glutation transferaze (GST) su enzimi koji su uključeni u procese metabolizma ksenobiotika i dio su kompleksnih mehanizama antioksidativne zaštite. Brojna istraživanja povezuju polimorfizam gena za GST sa predispozicijom za nastanak različitih bolesti, uključujuči dijabetes i dijabetičnu nefropatiju. Naši i rezultati drugih autora ukazuju na to da su genetske varijacije u enzimima koje su uključene u metabolizam slobodnih radikala povezane sa nastankom terminalne bubrežne insuficijencije kod bolesnika sa dijabetesom, što bi moglo postati osnova za razvoj preventivnih i ranih terapijskih strategija djelovanja kod osoba sa visokim rizikom.
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O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.5937/BII2102193T
primljen: 23.09.2021.
prihvaćen: 10.12.2021.
objavljen u SCIndeksu: 25.04.2022.
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