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Biomedicinska istraživanja
2021, vol. 12, br. 2, str. 193-203
Značaj polimorfizama glutation transferaza za nastanak dijabetične nefropatije
Pavlović Draganaa, Ristić Sinišab
aUniverzitetska bolnica Foča, Republika Srpska, BiH
bUniverzitet u Istočnom Sarajevu, Medicinski fakultet, Foča, Republika Srpska, BiH

e-adresa: draganatosovic@yahoo.com
Ključne reči: dijabetes; dijabetesna nefropatija; polimorfizam glutation transferaza
Sažetak
Genetički faktori i faktori sredine imaju važnu ulogu u nastanku dijabetes melitusa tip 2 (DM2) i njegovih komplikacija. Dijabetesna nefropatija (DN) jedna je od najčešćih mikroangiopatskih hroničnih komplikacija dijabetesa. Oksidativni stres nastaje u uslovima povećane produkcije slobodnih radikala i/ili smanjenja aktivnosti enzima antioksidativne zaštite i predstavlja bitnu kariku u složenom mehanizmu nastanka dijabetičnih vaskularnih promjena. Glutation transferaze (GST) su enzimi koji su uključeni u procese metabolizma ksenobiotika i dio su kompleksnih mehanizama antioksidativne zaštite. Brojna istraživanja povezuju polimorfizam gena za GST sa predispozicijom za nastanak različitih bolesti, uključujuči dijabetes i dijabetičnu nefropatiju. Naši i rezultati drugih autora ukazuju na to da su genetske varijacije u enzimima koje su uključene u metabolizam slobodnih radikala povezane sa nastankom terminalne bubrežne insuficijencije kod bolesnika sa dijabetesom, što bi moglo postati osnova za razvoj preventivnih i ranih terapijskih strategija djelovanja kod osoba sa visokim rizikom.
Reference

*** Renalni registar Bosne i Hercegovine. https://undt.ba/en_US/registar [homepage on the Internet], Available from: https://undt.ba/. [Accessed September 23, 2020]

1

Alicic, R.Z., Rooney, M.T., Tuttle, K.R. (2017) Diabetic Kidney Disease: Challenges, Progress, and Possibilities. Clin J Am Soc Nephrol, 12(12): 2032-2045

29

American Diabetes Association (2018) Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 41(1): S13-S27

Atkinson, H.J., Babbitt, P.C. (2009) Glutathione Transferases Are Structural and Functional Outliers in the Thioredoxin Fold. Biochemistry, 48(46): 11108-11116

Ballatori, N., Krance, S.M., Notenboom, S., Shi, S., Tieu, K., Hammond, C.L. (2009) Glutathione Dysregulation and the Etiology and Progression of Human Diseases. Biol Chem, 390(3): 191-214

Bessa, S.S., Ali, E.M., Hamdy, S.M. (2009) The Role of Glutathione Stransferase M1 and T1 Gene Polymorphisms and Oxidative Stress-Related Parameters in Egyptian Patients with Essential Hypertension. Eur J Intern Med, 20(6): 625-630

Bid, H.K., Konwar, R., Saxena, M., Chaudhari, P., Agrawal, C.G., Banerjee, M. (2010) Association of Glutathione S-Transferase (GSTM1, T1 and P1) Gene Polymorphisms with Type 2 Diabetes Mellitus in North Indian Population. J Postgrad Med, 56(3): 176-181

2

Board, P.G., Menon, D. (2013) Glutathione Transferases, Regulators of Cellular Metabolism and Physiology. Biochim Biophys Acta, 1830(5): 3267-3288

Cilenšek, I., Mankoč, S., Petrovič, M.G., Petrovič, D.G. (2012) GSTT1 Null Genotype Is a Risk Factor for Diabetic Retinopathy in Caucasians with Type 2 Diabetes, whereas GSTM1 Null Genotype Might Confer Protection against Retinopathy. Dis Markers, 32(2): 93-99

Datta, S.K., Kumar, V., Ahmed, R.S., Tripathi, A.K., Kalra, O.P., Banerjee, B.D. (2010) Effect of GSTM1 and GSTT1 Double Deletions in the Development of Oxidative Stress in Diabetic Nephropathy Patients. Indian J Biochem Biophys, 47(2): 100-103

Datta, S.K., Kumar, V., Pathak, R., Tripathi, A.K., Ahmed, R.S., Kalra, O.P., et al. (2010) Association of Glutathione S-Transferasem1 and T1 Gene Polymorphism with Oxidative Stress in Diabetic and Nondiabetic Chronic Kidney Disease. Ren Fail, 32(10): 1189-1195

3

Defronzo, R.A., Ferrannini, E., Groop, L., Henry, R.R., Herman, W.H., Holst, J.J., et al. (2015) Type 2 Diabetes Mellitus. Nat Rev Dis Primers, 1(1): 15019

Doney, A.S., Lee, S., Leese, G.P., Morris, A.D., Palmer, C.N. (2005) Increased Cardiovascular Morbidity and Mortality in Type 2 Diabetes Is Associated with the Glutathione S-Transferase Theta-Null Genotype: A Go-DARTS Study. Circulation, 111(22): 2927-2934

Folli, F., Corradi, D., Fanti, P., Davalli, A., Paez, A., Giaccari, A., et al. (2011) The Role of Oxidative Stress in the Pathogenesis of Type 2 Diabetes Mellitus Microand Macrovascular Complications: Avenues for a Mechanistic-Based Therapeutic Approach. Curr Diabetes Rev, 7(5): 313-324

Fujita, H., Narita, T., Meguro, H., Shimotomai, T., Kitazato, H., Kagaya, E., et al. (2000) No Association of Glutathione S-transferase M1 Gene Polymorphism with Diabetic Nephropathy in Japanese Type 2 Diabetic Patients. Ren Fail, 22(4): 479-486

1

Gadde, K.M., Martin, C.K., Berthoud, H.R., Heymsfield, S.B. (2018) Obesity: Pathophysiology and Management. J Am Coll Cardiol, 71(1): 69-84

Gaulton, K.J., Ferreira, T., Lee, Y., Raimondo, A., Mägi, R., Reschen, M.E., et al. (2015) Genetic Fine Mapping and Genomic Annotation Defines Causal Mechanisms at Type 2 Diabetes Susceptibility Loci. Nat Genet, 47(12): 1415-1425

Genuth, S., Alberti, K.G., Bennett, P., Buse, J., Defronzo, R., Kahn, R., et al. (2003) Follow-Up Report on the Diagnosis of Diabetes Mellitus. Diabetes Care, 26(11): 3160-3167

Gönül, N., Kadioglu, E., Kocabaş, N.A., Özkaya, M., Karakaya, A.E., Karahalil, B. (2012) The Role of GSTM1, GSTT1, GSTP1, and OGG1 Polymorphisms in Type 2 Diabetes Mellitus Risk: A Case-Control Study in a Turkish Population. Gene, 505(1): 121-127

5

Hayes, J.D., Flanagan, J.U., Jowsey, I.R. (2005) Glutathione Transferases. Annu Rev Pharmacol Toxicol, 45(1): 51-88

Ioannou, K. (2017) Diabetic Nephropathy: Is It Always There?: Assumptions, Weaknesses and Pitfalls in the Diagnosis. Hormones, Athens, 16(4): 351-361

Kahn, S.E., Cooper, M.E., del Prato, S. (2014) Pathophysiology and Treatment of Type 2 Diabetes: Perspectives on the Past, Present, and Future. Lancet, 383(9922): 1068-1083

Kim, J.H., Moon, M.K., Kim, S.W., Shin, H.D., Hwang, Y.H., Ahn, C., et al. (2005) Glutathione S-Transferase M1 Gene Polymorphism is Associated with Type 2 Diabetic Nephropathy. J Kor Diabetes Assoc, 29(4): 315-321

King, G.L., Loeken, M.R. (2004) Hyperglycemia-Induced Oxidative Stress in Diabetic Complications. Histochem Cell Biol, 122(4): 333-338

Lee, C., An, D., Park, J. (2016) Hyperglycemic Memory in Metabolism and Cancer. Horm Mol Biol Clin Investig, 26(2): 77-85

Lotfy, M., Adeghate, J., Kalasz, H., Singh, J., Adeghate, E. (2016) Chronic Complications of Diabetes Mellitus: A Mini Review. Curr Diabetes Rev, 13(1): 3-10

Luc, K., Schramm-Luc, A., Guzik, T.J., Mikolajczyk, T.P. (2019) Oxidative Stress and Inflammatory Markers in Prediabetes and Diabetes. J Physiol Pharmacol, 70(6)

Mannervik, B., Board, P.G., Hayes, J.D., Listowsky, I., Pearson, W.R. (2005) Nomenclature for Mammalian Soluble Glutathione Transferases. Methods Enzymol, 401: 1-8

Matic, M., Pekmezovic, T., Djukic, T., Mimic-Oka, J., Dragicevic, D., Krivic, B., et al. (2013) GSTA1, GSTM1, GSTP1, and GSTT1 Polymorphisms and Susceptibility to Smoking-related Bladder Cancer: A Case-Control Study. Urol Oncol, 31(7): 1184-1192

Morris, A.P., Voight, B.F., Teslovich, T.M., Ferreira, T., Segrè, A.V., Steinthorsdottir, V., et al. (2012) Large-Scale Association Analysis Provides Insights into the Genetic Architecture and Pathophysiology of Type 2 Diabetes. Nat Genet, 44(9): 981-990

National Kidney Foundation (2012) KDOQI Clinical Practice Guideline for Diabetes and CKDd 2012 Update. Am J Kidney Dis, 60(5): 850-886

Nelson, H.H., Wiencke, J.K., Christiani, D.C., Cheng, T.J., Zuo, Z.F., Schwartz, B.S., et al. (1995) Ethnic Differences in the Prevalence of the Homozygous Deleted Genotype of Glutathione S-Transferase Theta. Carcinogenesis, 16(5): 1243-1245

Nishikawa, T., Edelstein, D., Du, X.L., Yamagishi, S., Matsumura, T., Kaneda, Y., et al. (2000) Normalizing Mitochondrial Superoxide Production Blocks Three Pathways of Hyperglycaemic Damage. Nature, 404(6779): 787-790

Pavlovic, D. (2019) Povezanost polimorfizama gena za glutation transferaze M1 i T1 sa rizikom za nastanak dijabetesne nefropatije. Foča: Univerzitet u Istočnom Sarajevu - Medicinski fakultet Foča, Doktorska disertacija

Pinheiro, D.S., Rocha, F.C.R., Mundim, C.A., Júnior, P.D.M., Ulhoa, C.J., Reis, A.A.S., et al. (2013) Evaluation of Glutathione S-Transferase GSTM1 and GSTT1 Deletion Polymorphisms on Type-2 Diabetes Mellitus Risk. PloS One, 8(10): e76262

Ramasamy, R., Goldberg, I.J. (2010) Aldose Reductase and Cardiovascular Diseases, Creating Human-Like Diabetic Complications in an Experimental Model. Circ Res, 106(9): 1449-1458

Ristić, S., Lukić, L., Maksimović, Z., Marić, S., Marić, V., Kovačević, M., et al. (2012) High Prevalence of Risk Factors for Chronic Kidney Disease in Balkan Endemic Nephropathy Foci. Ren Fail, 34(4): 467-471

Saadat, M. (2017) Evaluation of Glutathione S-Transferase P1 (GSTP1) Ile105Val Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Meta-Analysis. EXCLI J, 16: 1188-1197

8

Shaw, J.E., Sicree, R.A., Zimmet, P.Z. (2010) Global Estimates of the Prevalence of Diabetes for 2010 and 2030. Diabetes Res Clin Pract, 87(1): 4-14

Shimizu, M., Furuichi, K., Wada, T. (2017) Epidemiology and Pathogenesis of Diabetic Nephropathy. Nihon Jinzo Gakkai Shi, 59(2): 43-49

Strain, W., Paldánius, P.M. (2018) Diabetes, Cardiovascular Disease and the Microcirculation. Cardiovasc Diabetol, 17(1): 57-57

Suvakov, S., Damjanovic, T., Stefanovic, A., Pekmezovic, T., Savic-Radojevic, A., Pljesa-Ercegovac, M., et al. (2013) Glutathione S-Transferase A1, M1, P1 and T1 Null or Low-Activity Genotypes Are Associated with Enhanced Oxidative Damage Among Haemodialysis Patients. Nephrol Dial Transplant, 28(1): 202-212

Tesauro, M., Nisticò, S., Noce, A., Tarantino, A., Marrone, G., Costa, A., et al. (2015) The Possible Role of Glutathione-S-Transferase Activity in Diabetic Nephropathy. Int J Immunopathol Pharmacol, 28(1): 129-133

1

The ADVANCE Collaborative Group (2008) Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med, 358(24): 2560-2572

Townsend, D.M., Tew, K.D. (2003) Cancer Drugs, Genetic Variation and the Glutathione-S-Transferase Gene Family. Am J Pharmacogenomics, 3(3): 157-172

Wang, G., Zhang, L., Li, Q. (2006) Genetic Polymorphisms of GSTT1, GSTM1, and NQO1 Genes and Diabetes Mellitus Risk in Chinese Population. Biochem Biophys Res Commun, 341(2): 310-313

Watters, J.W., Mcleod, H.L. (2002) Recent Advances in the Pharmacogenetics of Cancer Chemotherapy. Curr Opin Mol Ther, 4(6): 565-71

Witka, B.Z., Oktaviani, D.J., Marcellino, M., Barliana, M.I., Abdulah, R. (2019) Type 2 Diabetes-Associated Genetic Polymorphisms as Potential Disease Predictors. Diabetes Metab Syndr Obes, 12: 2689-2706

1

Wu, B., Dong, D. (2012) Human Cytosolic Glutathione Transferases: Structure, Function, and Drug Discovery. Trends Pharmacol Sci, 33(12): 656-668

Yalin, S., Hatungil, R., Tamer, L., Ates, N.A., Dogruer, N., Yildirim, H., et al. (2007) Glutathione S-Transferase Gene Polymorphisms in Turkish Patients with Diabetes Mellitus. Cell Biochem Funct, 25(5): 509-513

Yang, Y., Kao, M.T., Chang, C.C., Chung, S.Y., Chen, C.M., Tsai, J., et al. (2004) Glutathione S-Transferase T1 Deletion Is a Risk Factor for Developing End-stage Renal Disease in Diabetic Patients. Int J Mol Med, 14(5): 855-859

Zhang, J., Liu, H., Yan, H., Huang, G., Wang, B. (2013) Null Genotypes of GSTM1 and GSTT1 Contribute to Increased Risk of Diabetes Mellitus: A Meta-Analysis. Gene, 518(2): 405-411

Zhang, J., Liu, J., Qin, X. (2018) Advances in Early Biomarkers of Diabetic Nephropathy. Rev Assoc Med Bras, 64(1): 85-92
   

O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.5937/BII2102193T
primljen: 23.09.2021.
prihvaćen: 10.12.2021.
objavljen u SCIndeksu: 25.04.2022.
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