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2019, vol. 147, br. 11-12, str. 718-723
Teksturalni parametri hromatina neutrofilnih granulocita krvi su asocirani sa stepenom stresa kod bolesnika sa rekurentnim depresivnim poremećajem
aUniverzitet u Beogradu, Medicinski fakultet, Institut za fiziologiju, Srbija + Univerzitet u Haifi, Haifa, Izrael
bKlinički centar Srbije, Klinika za psihijatriju, Beograd, Srbija
cUniverzitet u Beogradu, Medicinski fakultet, Institut za fiziologiju, Srbija
dUniverzitet u Beogradu, Medicinski fakultet, Institut za anatomiju, Srbija
eUniverzitet u Istočnom Sarajevu, Istočno Sarajevo, Republika Srpska, BiH
fKatolički univerzitet "Jovan Pavle II", Lublin, Poljska

e-adresaigorpantic@gmail.com
Projekat:
Optičko mikroskopska, imunomorfološka, molekularno-biološka i genetska ispitivanja malignih i nemalignih bolesti bubrega (MPNTR - 175059)
Ćelijske i molekulske osnove malignih i kardiovaskularnih oboljenja-kliničke implikacije (MPNTR - 41027)
The authors are grateful to the project 92018 of the Mediterranean Society for Metabolic Syndrome, Diabetes and Hypertension in Pregnancy DEGU

Ključne reči: jedro; struktura; anksioznost; depresija
Sažetak
Uvod/Cilj Tokom proteklih 20 godina postojali su brojni pokušaji dizajniranja i primene jednostavnog, pristupačnog metoda za analizu krvi za dijagnostičke i prognostičke potrebe u psihijatriji. U ovom radu pokazujemo da su neki matematički parametri organizovanja i distribucije hromatina u neutrofilnim granulocitima krvi povezani sa nivoima stresa kod bolesnika sa dijagnozom rekurentnog depresivnog poremećaja. Metode Studija je sprovedena na 50 bolesnika sa dijagnozom rekurentnog depresivnog poremećaja, od kojih je zatraženo da popune upitnik za depresiju, anksioznost i stres (DASS-21). Uzorci periferne krvi dobijeni su od svih učesnika, napravljeni su razmazi na predmetnim staklima i obojeni korišćenjem modifikacije metode po Gimzi. Ukupno 500 reprezentativnih hromatinskih struktura (10 po bolesniku) neutrofila analizirano je korišćenjem teksturalne analize, odnosno matematičkog algoritma GLCM (gray level co-occurrence matrix). Izračunati su parametri poput angularnog drugog momenta (indikator teksturalne uniformnosti), inverznog momenta razlike (teksturalna homogenost) i teksturalne sume varijanse. Rezultati Rezultati pokazuju da postoji statistički značajna korelacija (p < 0,01) između određenih GLCM parametara hromatina, kao što je inverzni momenat razlike, i DASS-21 skora za stres. Postojala je i značajna razlika (p < 0,05) u nekim GLCM parametrima hromatina kod bolesnika sa dijagnostifikovanim depresivnim poremećajem sa psihotičkim karakteristikama u poređenju sa onima bez psihoze. Zaključak Ovi nalazi ukazuju na to da teksturalna analiza hromatina krvnih ćelija u budućnosti može imati određenu prediktivnu vrednost za neke kliničke osobine rekurentnog depresivnog poremećaja.
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O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.2298/SARH181030074P
objavljen u SCIndeksu: 16.01.2020.

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