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Vojnosanitetski pregled
2017, vol. 74, br. 7, str. 615-624
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 07/07/2017
doi: 10.2298/VSP150828084R
Creative Commons License 4.0
Dejstvo antidepresiva na serumske koncentracije markera metabolizma kosti i glavnih elektrolita kod bolesnika u rutinskoj psihijatrijskoj praksi
aSerbian Armed Forces, Institute of Aviation Medicine, Belgrade
bUniverzitet u Kragujevcu, Medicinski fakultet + Klinički centar Kragujevac, Služba za kliničku farmakologiju
cUniverzitet u Kragujevcu, Medicinski fakultet + Klinički centar Kragujevac, Klinika za psihijatriju
dUniverzitet u Kragujevcu, Medicinski fakultet + Klinički centar Kragujevac, Klinika za internu medicinu
eUniverzitet u Kragujevcu, Medicinski fakultet

e-adresa: piki@medf.kg.ac.rs

Projekat

Farmakološka analiza efekata biološki aktivnih supstanci na izolovane glatke mišiće gastrointestinalnog i urogenitalnog trakta čoveka (MPNTR - 175007)

Sažetak

Uvod/Cilj. Nema dovoljno podataka o uticaju antidepresiva na metabolizam kalcijuma, fosfora i magnezijuma. Cilj rada bio je da se istraže efekti antidepresiva na serumsku koncentraciju markera metabolizma kosti i glavnih elektrolita kod bolesnika u psihijatrijskoj praksi. Metode. U prospektivnu studiju, dizajna vremenske serije pre i posle, bio je uključeno 9 muškaraca i 24 žene, prosečne starosti 53,3 ± 11,5 godina, koji su bolovali od depresije n = 26 i neurotičnih poremećaja n = 7 i koji su uglavnom lečeni selektivnim inhibitorima preuzimanja serotonina. Određivani su analiti na početku, u 4, 6. i 12. nedelje lečenja i analizirane promene parametara i trendovi u odnosu na početne vrednosti uz statističku značajnost od p ≤ 0,05. Rezultati. Utvrđeno je da starost iznad 60 godina predstavlja značajan faktor rizika od pojave negativnih kumulativnih promena (u procentima) u odnosu na bazalne koncentracije 25-hidroksivitamina D - 25(OH)D (OR = 11,4, 95% CI 1,2-113,1, p = 0,037). Koncentracije kalcijuma u serumu značajno su korelisale sa koncentracijama natrijuma (rs = 0,531, p < 0,001), hlorida (r = 0,496, p < 0,001), magnezijuma (rs = 0,402, p < 0.001 i osteokalcina r = 0,240, p = 0,019. Značajne korelacije nađene su između koncentracija fosfora i hlorida (r = -0,218, p = 0,035); magnezijuma i natrijuma (r = 0,295, p = 0,004) i kalijuma (r = 0,273, p = 0,009); osteokalcina i C-telopeptida (r = 0,760, p < 0,001), natrijuma (r = 0,215, p = 0,039) i hlorida (r = 0,209, p = 0,041); natrijuma i hlorida (r = 0,722, p < 0,001). Nije utvrđena statistički značajna razlika između terapije antidepresivima i promena apsolutnih vrednosti serumskih koncentracija kalcijuma, magnezijuma, fosfora, 25 OH D, osteokalcina, C-telopeptida, natrijuma, kalijuma i hlorida. Takođe nisu utvrđene statistički značajne razlike ni u učestalosti poremećaja i vrednostima laboratorijskih analita (ispod/iznad donje/gornje granice referentnih vrednosti. Zaključak. Lečenje antidepresivima nije značajno povezano sa promenama studijskih analita ali neki od njih su međusobno bili u pozitivnoj korelaciji, što sugeriše potrebu individualnog pristupa bolesniku i daljih istraživanja u oblasti kosti metabolizma kod osoba sa mentalnim poremećajima.

Ključne reči

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