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Vojnosanitetski pregled
2015, vol. 72, br. 12, str. 1098-1104
jezik rada: engleski
vrsta rada: originalan članak
doi:10.2298/vsp140718115s
Epidemija infekcija centralnog nervnog sistema virusom zapadnog Nila na teritoriji Južnobačkog okruga, Vojvodina, Srbija
aClinic for Infectious Diseases, Clinical Center of Vojvodina, Faculty of Medicine, Novi Sad
bHealth Care Center 'Novi Sad', Novi Sad
cKlinički centar Novi Sad

e-adresa: sevicsinisa@yahoo.com

Projekat

Praćenje zdravstvenog stanja divljači i uvođenje novih biotehnoloških postupaka u detekciji zaraznih i zoonoznih agenasa - analiza rizika za zdravlje ljudi, domaćih i divljih životinja i kontaminaciju životne sredine (MPNTR - 31084)

Sažetak

Uvod/Cilj. Virus West Nile (WNV) je neurotropna RNA virusna partikula koja pripada porodici Flaviviridae, rodu Flavivirus. Održava se u artropodama u okviru transmisivnog ciklusa između komaraca i ptica. WNV infekcije su asimptomatske kod 80% ljudi. Manje od 1% inficiranih osoba razvije neuroinvazivni oblik bolesti, meningitis, encefalitis ili akutnu flakcidnu paralizu. Cilj rada bio je da se utvrde najčešće kliničko-laboratorijske manifestacije, prisustvo komorbiditeta i ishod lečenja kod obolelih od WNV infekcije. Metode. U ovu retrospektivnu studiju, sprovedenu u periodu od 1. 1. 2012. do 31. 12. 2013. godine, bila su uključena 32 bolesnika, kojima je na osnovu kliničkog nalaza, laboratorijskih i seroloških analiza dijagnostikovana WNV infekcija. U svrhu ocene statističke značajnosti korišćeni su χ2 i t-test. Rezultati. U studiju je bilo uključeno 22 (69%) bolesnika muškog pola i 10 (31%) žena, starosti 31 do 65 godina. Povišenu temperaturu na prijemu imalo je 16 (50%) bolesnika, pozitivne meningealne znake 27 (84.4%), patološke neurološke znake 17 (53,2%), a poremećaj stanja svesti 10 (31,3%). WNV infekcija je kod svih obolelih potvrđena metodom enzyme linked immuno sorbent assay (ELISA). Istovremeno reverse transcription polymerase chain reaction (RT-PCR) test bio je pozitivan kod 3 (30%) testirana bolesnika. Od komorbiditeta, najčešće su registrovane kardiovaskularne bolesti, kod 7 (21,9%) bolesnika. Potpuni oporavak postignut je kod 87,5% bolesnika. Zaključak. Rezultati naše studije pokazali su da su odsustvo febrilnosti i pozitivnih meningealnih znakova sedmog dana hospitalizacije pokazatelji dobrog ishoda neuroinvazivnih oblika WNV infekcije, a da prisustvo komorbiditeta ne povećava rizik od obolevanja od ove bolesti. ELISA predstavlja vrhunsku metodu za postavljanje dijagnoze. Kod najvećeg broja obolelih simptomatska terapija dovodi do potpunog oporavka.

Ključne reči

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