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Journal of Medical Biochemistry
2015, vol. 34, iss. 2, pp. 160-169
article language: English
document type: Original Scientific Paper
doi:10.2478/jomb-2014-0037


Oxidized low density lipoprotein and high sensitive C-reactive protein in non-diabetic, pre-diabetic and diabetic patients in the acute phase of the first myocardial infarction treated by primary percutaneous coronary intervention
aClinical Centre of Serbia, Department of Cardiology + University of Belgrade, School of Medicine
bUniversity of Belgrade, School of Pharmacy, Clinical Centre of Serbia, Center for Medical Biochemistry
cUniverzitet u Beogradu, Medicinski fakultet, Institut za medicinsku statistiku i informatiku
dUniverzitet u Beogradu, Medicinski fakultet, Klinički centar Srbije
eUniversity of Belgrade + Serbian Academy of Sciences and Arts

e-mail: danijelatrif@gmail.com

Project

145053

Abstract

Background: Oxidized low density lipoprotein (ox-LDL) and high-sensitive C-reactive protein (hs-CRP) are elevated in diabetes mellitus (DM) and associated with accelerated atherosclerosis. Little is known about their dynamics in the acute phase of ST segment elevation myocardial infarction (STEMI), especially in relation to the presence of DM and pre-diabetes (pre-DM). This study aimed to analyze time-dependent changes in ox-LDL and hs-CRP regarding the presence of pre-DM and DM in STEMI patients treated by primary percutaneous coronary intervention (pPCI). Methods: In 103 consecutive patients with the first anterior STEMI ox-LDL and hs-CRP were measured before pPCI, on day 2 and day 7 after pPCI. Results: Patients were classified into: non-diabetics, pre-diabetics and diabetics. In each group the maximal ox-LDL concentration was found on admission, decreased on day 2 and reached the lowest values on day 7 (p<0.001). Diabetics had the highest ox-LDL concentrations compared to pre-diabetics and non-diabetics (on admission: p=0.028, on day 2: p= 0.056, on day 7: p=0.004). hs-CRP concentration rose from admission, reached its peak on day 2 and decreased on day 7, in each group (p<0.001). Significant differences in hs-CRP concentrations were found between non-diabetics and pre-diabetics on admission (p=0.018) and day 2 (p=0.026). In a multivariate analysis DM was an independent determinant of high ox-LDL concentrations. Both ox-LDL and hs-CRP significantly correlated with Killip class, left ventricular ejection fraction, NT-proBNP and peak troponin I. Conclusions: In patients with the first STEMI treated by pPCI there were significant differences in ox-LDL and hs-CRP concentrations between non-diabetics, pre-diabetics and diabetics. Ox-LDL and hs-CRP concentrations were related to heart failure parameters.

Keywords

oxidized LDL; high-sensitive C-reactive protein; acute myocardial infarction; diabetes mellitus

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