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Praxis medica
2017, vol. 46, br. 3-4, str. 1-5
jezik rada: srpski
vrsta rada: originalan članak
doi:10.5937/pramed1704001K

Creative Commons License 4.0
Tehnike randomizacije u protokolima za klaster randomizovane studije
aUniverzitet u Prištini, Medicinski fakultet Priština, sedište Kosovska Mitrovica, Institut za preventivnu medicinu, Kosovska Mitrovica
bUniverzitet u Beogradu, Medicinski fakultet, Institut za medicinsku statistiku i informatiku
cUniverzitet u Beogradu, Medicinski fakultet

e-adresa: mirjana.kostic@med.pr.ac.rs

Sažetak

Klaster randomizovane studije zbog svog sprecifičnog dizajna zahtevaju posebnu pažnju prilikom planiranja. Da bi se postigao balans i na nivou klastera i na nivou pojedinca kod ovih studija potrebno je primeniti tehnike randomizacije koje podrazumevaju ograničenu randomizaciju. Cilj: Utvrditi načine randomizacije i njihovu učestalost u protokolima za klaster randomizovane studije. Materijali i metod: Pretraživanjem bibliografske baze podataka MEDLINE dobijeno je 1020 bibliografskih jedinica, a u analizu su ušli samo protokoli za klaster randomizovane studije što je činilo ukupno 169 studija. Ekstrahovani su podaci o tehnikama randomizacije, jedinicama randomizacije i godine publikovanja protokola. Rezultati:Tehnika randomizacije sa najvećom učestalošću bila je stratifikacija (35,9%). Nakon stratifikacije najučestalija je prosta randomizacija (13,5%), zatim kombinacija blok i stratifikacije (10%), blok randomizacija (9,4%) i mečovanje (9,4%). Najučestalije jedinice randomizacije su zdravstvene ustanove (52%). Broj publikovanih protokola statistički značajno raste tokom vremena (p<0,01). Zaključak: Istraživači češće pribegavaju tehnikama randomizacije koje podrazumevaju ograničenu randomizaciju.

Ključne reči

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