Article metrics

  • citations in SCindeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[=>]
  • visits in previous 30 days:2
  • full-text downloads in 30 days:2
article: 3 from 4  
Back back to result list
Scripta Medica
2011, vol. 42, iss. 2, pp. 80-83
article language: Serbian
document type: Original Scientific Paper
published on: 10/10/2019
doi: 10.5937/ScriMed1102080V
Metabolic syndrome affects stroke
aUniversity of Banja Luka, Faculty of Medicine, Department of Pathophysiology, Republic of Srpska, B&H
bUniversity Clinical Centre of the Republic of Srpska, Clinic of Neurology, Banja Luka, Republic of Srpska, B&H
cUniversity Clinical Centre of the Republic of Srpska, Banja Luka, Republic of Srpska, B&H

e-mail: miloradv79@yahoo.com

Project

M. V. je dobitnik finansijske pomoći Ministarstva za nauku i tehnologiju Vlade RS za izradu ovog istraživanja.

Abstract

Introduction. Metabolic syndrome is a set of metabolic and hemodynamic disorders that appear associated with certain persons and multiply the risk of atherosclerotic cardiovascular diseases and diabetes mellitus type 2. The aim of this study was to examine the prevalence of metabolic syndrome in patients with ischemic stroke, to analyze the representation of individual components of metabolic syndrome, and to determine the risk of ischemic stroke in relation to the number of individual metabolic syndrome components. Methods. The study was conducted at the Institute "Dr Miroslav Zotović". The experimental group included 53 examinees who had ischemic stroke and control group included 40 examinees with degenerative lumbo-sacral spine diseases.Data on waist circumferences, blood pressure, blood glucose, triglycerides and HDL holesterol levels were recorded for all examinees. Diagnosis of metabolic syndrome was set based on new criteria, which were agreed by a number of international organizations in 2009. year. Results. The prevalence of metabolic syndrome in examinees with ischemic stroke amounted 89% and 70% of the control group (p<0.05). The most common single component of the metabolic syndrome in the group with stroke was hypertension (100%) and least common one was impaired glycoregulation (51%). Out of all examinees who had three individual components of metabolic syndrome 33% had ischemic stroke, while the percentage of those who had all five individual components was 77% (p<0.05). Conclusion. There is significantly higher prevalence of metabolic syndrome in examinees with ischemic stroke than in the control group. The most common single component of the metabolic syndrome in the experimental group was hypertension. The presence of a large number of individual components of metabolic syndrome increases the risk for developing ischemic stroke.

Keywords

References

Alberti, K.G.M.M., Eckel, R.H., Grundy, S.M., Zimmet, P.Z., Cleeman, J.I., Donato, K.A. (2009) Harmonizing the metabolic syndrome: A joint interim statement of the International diabetes federation task force on epidemiology and prevention. Circulation, 120(16): 1640-5, National heart, lung, and blood institute; American heart association; World heart federation; International atherosclerosis society; and International association for the study of ob
Chen, H., Bai, C., Yeh, W., Chiu, H., Pan, W. (2006) Influence of metabolic syndrome and general obesity on the risk of ischemic stroke. Stroke, 37(4): 1060-1064
da Silva, D.A., Woon, F.P., Xie, X.Y., Chen, C.L.H., Chang, H.M., Wong, M.C. (2007) Metabolic syndrome among ethnic South Asian patients with ischemic stroke and comparison with ethnic Chinese patients: The Singapore general hospital experience. J Stroke Cerebrovasc Dis, 16: 119-21
Defronzo, R.A., Abdul-Ghani, M. (2011) Assessment and treatment of cardiovascular risk in prediabetes: Impaired glucose tolerance and impaired fasting glucose. American Journal of Cardiology, 108(3 Suppl): 3B-24B
Dekker, J.M., Girman, C., Rhodes, T., Nijpels, G., Stehouwer, C.D.A., Bouter, L.M., Heine, R.J. (2005) Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study. Circulation, 112(5): 666-673
Doi, Y., Ninomiya, T., Hata, J., Yonemoto, K., Arima, H., Kubo, M., Tanizaki, Y., Iwase, M., Iida, M., Kiyohara, Y. (2009) Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: The Hisayama study. Stroke, 40(4): 1187-1194
Grundy, S.M., Cleeman, J.I., Daniels, S.R., Donato, K.A., Eckel, R.H., Franklin, B.A., Gordon, D.J., Krauss, R.M., Savage, P.J., Smith, S.C., Spertus, J.A., Costa, F. (2005) Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation, 112(17): 2735-52
Handelsman, Y. (2009) Metabolic syndrome pathophysiology and clinical presentation. Toxicologic Pathology, 37(1): 18-20
Huang, P.L. (2009) A comprehensive definition for metabolic syndrome. Disease Models & Mechanisms, 2(5-6): 231-237
International Diabetes Federation (2005) The IDF consensus worldwide definition of the metabolic syndrome
Malik, S., Wong, N.D., Franklin, S.S., Kamath, T.V., L'italien, G.J., Pio, J.R., Williams, G. R. (2004) Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation, 110(10): 1245-1250
Milionis, H.J., Kostapanos, M.S., Liberopoulos, E.N., Goudevenos, J., Athyros, V.G., Mikhailidis, D.P., Elisaf, M.S. (2007) Different definitions of the metabolic syndrome and risk of first-ever acute ischaemic non-embolic stroke in elderly subjects. International Journal of Clinical Practice, 61(4): 545-551
Morag, N.K., Goldbourt, U., Tanne, D. (2005) Relation between the metabolic syndrome and ischaemic stroke or transient ischaemic attack: A prospective cohort study in patients with atherosclerotic cardiovascular disease. Stroke, 36: 1366-71
Olijhoek, J.K., van der Graaf, Y., Banga, J., Algra, A., Rabelink, T.J., Visseren, F.L.J. (2004) The Metabolic Syndrome is associated with advanced vascular damage in patients with coronary heart disease, stroke, peripheral arterial disease or abdominal aortic aneurysm. European Heart Journal, 25(4): 342-348
Reffat, S., Sheikh, B., Fath-El-bab, M., Gabal, A.M., Ibrahim, M., Hassan, A., Sandgji, H. (2010) Metabolic syndrome in acute stroke patients in Al-Madinah Al-Munawarah Kingdom of Saudi Arabia. Journal of Medicine and Biomedical Sciences, 1: 2078-83