• citations in SCIndeks: [1]
  • citations in CrossRef:0
  • citations in Google Scholar:[]
  • visits in previous 30 days:6
  • full-text downloads in 30 days:6


article: 7 from 8  
Back back to result list
2016, vol. 50, iss. 2, pp. 54-62
The role of hyperhomocysteinemia in the development of postoperative vascular complications
aUniversity of Priština - Kosovska Mitrovica, Faculty of Medicine, Clinical Hospital Center
bClinical Center Kragujevac, Clinic for General and Thoracic Surgery + University of Kragujevac, Faculty of Medical Sciences
Hyperhomocysteinemia is one of the unconventional risk factors of cardiovascular morbidity - it is causally associated in both directions with oxidative stress, endothelial dysfunction, mechanisms of cell signaling and apoptosis. Numerous clinical and experimental studies have explained the mechanisms and clinical expression of atherosclerotic and prothrombotic effects of homocysteine. The main pathological substrate, previous therapy, and surgical procedure-intervention itself are associated with the state of oxidative stress and endothelial dysfunction, which is one of important factors for elevated plasma homocysteine levels. Recent studies point to the possibility of a successful correction of hyperhomocysteinemia, especially secondary one.
Bakoyiannis, C., Karaolanis, G., Moris, D., i dr. (2015) Homocysteine as a risk factor of restenosis after carotid endarterectomy. Int Angiol, 34: 166-71
Balogh, E. (2016) Plasma homocysteine levels are related to medium-term venous graft degeneration in coronary artery bypass graft patients. Anatolian Journal of Cardiology, 16: 868-73
Carluccio, M.A., Ancora, M.A., Massaro, M., Carluccio, M., Scoditti, E., Distante, A., Storelli, C., de Caterina, R. (2007) Homocysteine induces VCAM-1 gene expression through NF- B and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants. AJP: Heart and Circulatory Physiology, 293(4): H2344-H2354
Cascella, M., Arcamone, M., Morelli, E., Viscardi, D., Russo, V., de Franciscis, S., Belli, A., Accardo, R., Caliendo, D., de Luca, E., di Caprio, B., di Sauro, F., Giannoni, G., Iermano, C. (2015) Multidisciplinary approach and anesthetic management of a surgical cancer patient with methylene tetrahydrofolate reductase deficiency: a case report and review of the literature. Journal of Medical Case Reports, 9(1):175
Ekim, M., Sekeroglu, M. R., Balahoroglu, R., Ozkol, H., Ekim, H. (2014) Roles of the Oxidative Stress and ADMA in the Development of Deep Venous Thrombosis. Biochemistry Research International, 2014: 1-5
Gurda, D., Handschuh, L., Kotkowiak, W., Jakubowski, H. (2015) Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells. Amino Acids, 47(7): 1319-1339
Handy, D.E., Zhang, Y., Loscalzo, J. (2005) Homocysteine Down-regulates Cellular Glutathione Peroxidase (GPx1) by Decreasing Translation. Journal of Biological Chemistry, 280(16): 15518-15525
Hron, G., Lombardi, R., Eichinger, S., Lecchi, A., Kyrle, P.A., Cattaneo, M. (2007) Low vitamin B6 levels and the risk of recurrent venous thromboembolism. Haematologica, 92(9): 1250-1253
Jiang, X., Wu, B., Kang, J. (2015) Analysis of Risk Factors for Lower-limb Deep Venous Thrombosis in Old Patients after Knee Arthroplasty. Chinese Medical Journal, 128(10): 1358
Lech, M., Kościelniak, B., Bryk, A., Undas, A. (2016) Determinants of the elevated factor VIII activity in patients following venous thromboembolism. Przegl Lek, 73: 210-5
Loscalzo, J. (1996) The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest, 98(1): 5-7
Lubos, E., Loscalzo, J., Handy, D.E. (2007) Homocysteine and Glutathione Peroxidase-1. Antioxidants & Redox Signaling, 9(11): 1923-1940
Lupoli, R., di Minno, A., Spadarella, G., Franchini, M., Sorrentino, R., Cirino, G., di Minno, G. (2015) Methylation Reactions, the Redox Balance and Atherothrombosis: The Search for a Link with Hydrogen Sulfide. Seminars in Thrombosis and Hemostasis, 41(04): 423-432
Mccully, K.S. (2007) Homocysteine, vitamins, and vascular disease prevention. Am J Clin Nutr, 86(5):1563S-8S
Park, W., Chang, J. (2014) Clinical Implications of Methylenetetrahydrofolate Reductase Mutations and Plasma Homocysteine Levels in Patients with Thromboembolic Occlusion. Vascular Specialist International, 30(4): 113-119


article language: Serbian
document type: Review Paper
DOI: 10.5937/mckg50-11492
published in SCIndeks: 25/03/2017

Related records

Opšta medicina (2006)
Hyperhomocysteinemia and vascular disease
Čeperković Zoran

Srps arh celokup lekarstvo (2000)
Hiperhomocisteinemija kao faktor rizika za kardiovaskularne bolesti
Koraćević Goran, et al.

Scripta Medica (2013)
Risk factors for Venous thromboembolism and duration of anticoagulation therapy
Antonijević Nebojša M., et al.