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Medicinski časopis
2016, vol. 50, br. 2, str. 54-62
jezik rada: srpski
vrsta rada: pregledni članak
objavljeno: 25/03/2017
doi: 10.5937/mckg50-11492
Uloga hiperhomocisteinemije u nastanku postoperativnih vaskularnih komplikacija
aUniverzitet u Prištini sa privremenim sedištem u Kosovskoj Mitrovici, Medicinski fakultet, Kliničko-bolnički centar
bKlinički centar Kragujevac, Klinika za opštu i grudnu hirurgiju + Univerzitet u Kragujevcu, Medicinski fakultet

e-adresa: mladenpavlovic@gmx.com

Sažetak

Hiperhomocisteinemija se ubraja u nekonvencionalne faktore rizika kardiovaskularnog morbiditeta - uzročno-posledično je u oba smera povezana sa oksidativnim stresom, endotelnom disfunkcijom, ćelijskim signalnim mehanizmima i apoptozom. Brojne kliničke i eksperimentalne studije su objasnile mehanizme i kliničku ekspresiju protrombotičnog i aterosklerotičnog delovanja homocisteina. Osnovni patološki supstrat, prethodna terapija i sama hirurška intervencija povezani su sa stanjem oksidativnog stresa i endotelne disfunkcije, čiji je jedan od važnih činilaca povišen plazmatski nivo homocisteina. Novija istraživanja ukazuju na mogućnosti uspešnog korigovanja hiperhomocisteinemije, posebno sekundarne.

Ključne reči

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