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Srpski arhiv za celokupno lekarstvo
2019, vol. 147, iss. 7-8, pp. 488-491
article language: English
document type: Book/Journal Review
published on: 15/08/2019
doi: 10.2298/SARH181121034C
Malaria in the 21st century: Still a threatening problem
aClinical Centre Kragujevac, Clinic for Infectious Diseases + University of Kragujevac, Faculty of Medicine



There are six parasite species (P. falciparum, P. vivax, P. ovale curtisi, P. ovale wallikeri, P. malariae, and P. knowlesi) that cause malaria in humans. P. falciparum is responsible for most malaria-related deaths globally. P. vivax is the dominant malaria parasite in most countries outside of the Sub-Saharan Africa. In 2016, 91 countries reported a total of 216 million cases of malaria. The global tally of malaria deaths reached 445,000. In 2016, 24 cases of imported malaria were registered in the Republic of Serbia, with an incidence of 0.33/100,000. According to the World Health Organization recommendations, every suspected malaria case should be confirmed by microscopy or a rapid diagnostic test before treatment. The main stone of antimalarial therapy should be artemisinin-based combinations. Since malaria occurs in Europe as an imported (though rarely also autochthonous and a hospital-borne infection), the objective of this paper is to point out current problems and attitudes in the diagnosis and treatment of malaria, without entering the data field significant for professionals (infectologists, epidemiologists, intensivists).



Ashley, E.A., Dhorda, M., Fairhurst, R.M., Amaratunga, C., Lim, P., Suon, S., et al. (2014) Spread of Artemisinin Resistance in Plasmodium falciparum Malaria. New England Journal of Medicine, 371(8): 786-786
Ashley, E.A., Phyo, A.P. (2018) Drugs in Development for Malaria. Drugs, 78(9): 861-879
Baird, K.J. (2013) Malaria caused by Plasmodium vivax: Recurrent, difficult to treat, disabling, and threatening to life -averting the infectious bite preempts these hazards. Pathog Glob Health, 107(8): 475-484
Bouchaud, O., Mühlberger, N., Parola, P., Calleri, G., Matteelli, A., Peyerl-Hoffmann, G., Méchaï, F., Gautret, P., Clerinx, J., Kremsner, P.G., Jelinek, T., Kaiser, A., Beltrame, A., Schmid, M.L. (2012) Therapy of uncomplicated falciparum malaria in Europe: MALTHER: A prospective observational multicentre study. Malaria Journal, 11(1): 212-212
Centers for Control and Disease Prevention (CDC) (2015) Rapid diagnostic tests: How they work. [internet]. [cited 2018 Sept 8]; Avaible from:
Cui, L., Su, X. (2009) Discovery, mechanisms of action and combination therapy of artemisinin. Expert Review of Anti-infective Therapy, 7(8): 999-1013
Dakić, Z., Kulišić, Z., Stajković, N., Pelemiš, M., Čobeljić, M., Stanimirović, Z., Inđić, N., Poluga, J., Pavlović, M. (2008) Ecology of Anopheles mosquitoes in Belgrade area: Estimating vector potential for malaria retransmission. Acta veterinaria, vol. 58, br. 5-6, str. 603-614
Dakić, Z., Ivović, V., Pavlović, M., Lavadinović, L., Marković, M., Djurković-Djaković, O. (2014) Clinical significance of molecular methods in the diagnosis of imported malaria in returning travelers in Serbia. International Journal of Infectious Diseases, 29: 24-30
Dakić, Z., Pelemiš, M., Djurković-Djaković, O., Lavadinović, L., Nikolić, A., Stevanović, G., Poluga, J., Ofori-Belić, I., Milošević, B., Pavlović, M. (2011) Imported malaria in Belgrade, Serbia, between 2001 and 2009. Wiener klinische Wochenschrift, 123(S1): 15-19
Draper, S.J., Sack, B.K., King, R.C., Nielsen, C.M., Rayner, J.C., Higgins, M.K., Long, C.A., Seder, R.A. (2018) Malaria Vaccines: Recent Advances and New Horizons. Cell Host & Microbe, 24(1): 43-56
European Centre for Disease Prevention and Control (ECDC) (2018) Rapid risk assessment: Hospital-acquired malaria infections in the European Union. Stockholm, 30 April 2018, [internet]. [cited 2018 Sept 28]; Available from:
Eyasu, M. (2015) Antimalarial Drug Resistance: In the Past, Current Status and Future Perspectives. British Journal of Pharmacology and Toxicology, 6(1): 1-15
God, P.G., Frey, A., Eisenhut, M. (2008) Artemisinin derivatives versus quinine in treating severe malaria in children: A systematic review. Malar J, 7: 210-210
Jovanović, V., ur. (2017) Izveštaj o zaraznim bolestima u Republici Srbiji za 2016. godinu. Beograd: Institut za javno zdravlje Srbije 'Dr Milan Jovanović Batut', [internet]. str. 48-9. [cited 2018 Sept 26]; Avaible from:
Kavran, M., Zgomba, M., Weitzel, T., Petric, D., Manz, C., Becker, N. (2018) Distribution of Anopheles daciae and other Anopheles maculipennis complex species in Serbia. Parasitology Research, 117(10): 3277-3287
Kuladeepa, V.A., Sukesh, A. (2012) Quantitative buffy coat (QBC) test and other diagnostic techniques for diagnosing malaria: Review of literature. Natl J of Med Res, 2(3): 386-394
Kurth, F., Develoux, M., Mechain, M., Malvy, D., Clerinx, J., Antinori, S., Gjørup, I.E., Gascon, J., Mørch, K., Nicastri, E., Ramharter, M., Bartoloni, A., Visser, L., Rolling, T., Zanger, P. (2017) Severe malaria in Europe: An 8-year multi-centre observational study. Malaria Journal, 16(1): 57-57
Lalloo, D.G., Shingadia, D., Bell, D.J., Beeching, N.J., Whitty, C.J.M., Chiodini, P.L. (2016) PHE Advisory Committee on Malaria Prevention in UK Travellers: UK malaria treatment guidelines 2016. J Infect, 72(6): 635-684
Manjunath, P., Salmani,, Peerapur, B.V. (2011) Comparative study of peripheral blood smear, QBC and antigen detection in malaria diagnosis. J Clin Diagn Res, 5(5): 967-976
Mukry, S.N., Saud, M., Sufaida, G.M., Shaikh, K., Naz, A., Shamsi, T.S. (2017) Laboratory Diagnosis of Malaria: Comparison of Manual and Automated Diagnostic Tests. Canadian Journal of Infectious Diseases and Medical Microbiology, 2017: 1-7
Piperaki, E.T., Daikos, G.L. (2016) Malaria in Europe: Emerging threat or minor nuisance?. Clinical Microbiology and Infection, 22(6): 487-493
Schwartz, E. (2012) Prophylaxis of Malaria. Mediterranean Journal of Hematology and Infectious Diseases, 4(1): e2012045-e2012045
Shreekant, D., Bhimanna, K. (2016) 4-aminoquinolines: An overview of antimalarial chemotherapy. Med chem, 6: 1-011
Toovey, S., Nieforth, K., Smith, P., Schlagenhauf, P., Adamcova, M., Tatt, I., Tomianovic, D., Schnetzler, G. (2014) Comparative benefit of malaria chemoprophylaxis modelled in United Kingdom travellers. Travel Medicine and Infectious Disease, 12(6): 726-732
Toure, O.A., Rulisa, S., Anvikar, A.R., Rao, B.S., Mishra, P., Jalali, R.K., Arora, S., Roy, A., Saha, N., Iyer, S.S., Sharma, P., Valecha, N. (2015) Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate dispersible tablets in paediatric patients with acute uncomplicated Plasmodium falciparum malaria: A phase II, multicentric, open-label study. Malaria Journal, 14(1): 469-469
Watson, J., Taylor, W.R., Bancone, G., Bancone, G., Chu, C.S., Jittamala, P., et al. (2018) Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria. PLOS Neglected Tropical Diseases, 12(4): e0006440-e0006440
Wilby, K.J., Lau, T.T., Gilchrist, S.E., Ensom, M.H. (2012) Mosquirix (RTS,S): A Novel Vaccine for the Prevention of Plasmodium falciparum Malaria. Annals of Pharmacotherapy, 46(3): 384-393
Wilosn, L.M. (2012) Malaria Rapid Diagnostic Tests. Clinical Infectious Diseases, 54(11): 1637-1641
World Health Organization (WHO) (2015) Guidelines for the treatment of malaria. Geneva, third edition, (
World Health Organization (WHO) (2017) Guidelines for the treatment of malaria. third edition [internet]. [cited 2018 Sept 8]; Available from: atoz/9789241549127/en