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Serbian Journal of Experimental and Clinical Research
2019, vol. 20, iss. 1, pp. 33-38
article language: English
document type: Original Paper
published on: 12/05/2019
doi: 10.1515/SJECR-2017-0023
Tumor necrosis factor-alpha as differential diagnostic marker for patients with fever of unknown origin
aUniversity of Kragujevac, Faculty of Medicine
bUniversity of Kragujevac, Faculty of Medicine
cUniversity of Kragujevac, Faculty of Medicine, Department of Internal Medicine
dUniversity of Kragujevac, Faculty of Medicine, Department of Microbiology and Immunology



Febrile conditions of unidentifi ed origin are still unknown in modern medicine despite the development of diagnostic procedures. Th ere are various agents of long-term temperature encompassing numerous infectious or non-infectious diseases. Th e aim of this study was to determine if there was a statistically signifi cant diff erence in the values of proinfl amma-tory cytokines (IL-1, TNFα, IL-6) in patients who meet the criteria for febrile conditions of unidentifi ed origin, between the group of infectious, malignant, rheumatic, "other" diseases and undiagnosed patients. Th e study was conducted in the Immunology laboratory of the Center for Molecular Medicine and Stem Cells Research of the Faculty of Medical Sciences in Kragujevac. Blood samples were taken from patients tested at the Clinic for Infectious Diseases , of the Clinical Center of Kragujevac, in the period from 2014 to 2016. Th e study included 70 patients. Th e measured values of the level of TNFα showed significantly higher values in a group of malignant diseases than in the group of infectious diseases, while the values of IL-1 and IL-6 did not show statistical signifi cance. TNFα can improve diagnosing in case of patients with an unknown febrile condition, which can shorten the length of the hospital stay and reduce the volume of performance of diagnostic procedures.


temperature; temperature of an unknown cause; IL-1; TNFα; IL-6