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Timočki medicinski glasnik
2018, vol. 43, iss. 3, pp. 118-131
article language: Serbian
document type: Book/Journal Review
published on: 01/02/2019
doi: 10.5937/tmg1803118J
Sepsis and acute kidney injury: Patophysiological mechanisms and basic principles of treatment
aMedicines and medical devices agency of Serbian, Belgrade
bHealth center Zaječar, Department of nephrology and hemodialysis, Zaječar
cClinical Center Kragujevac, Clinic for Urology, Nephrology and Dialysis + University of Kragujevac, Faculty of Medicine
dMedical center Tutin, Center of hemodialysis, Tutin
eUniversity of Kragujevac, Faculty of Medicine
fUniversity of Kragujevac, Faculty of Medicine + Clinical Centre Kragujevac, Clinic for Infectious Diseases



Medical costs structure and budget impact analysis regarding most prevalent and/or most expensive diseases and cost/effectiveness/utility coefficient determination of common medical interventions (MESTD - 175014)


Authors would like to express their gratitude to the Ministry of Education, Science and Technological Development of the Republic of Serbia for the Grant N0175014, from which the funds were used as one of the sources to financially support this paper. Summary: Sepsis is the main cause of the development of acute kidney injury in critical ill patients in intensive care units. A reinforced and uncontrolled response of the host immune system to bacterial infection has a significant role in the pathogenesis of acute kidney injury in patients with sepsis. Early target therapy, early administration of antibiotics, optimal control of the site of infection, and kidney replacement therapy play a key role in the treatment of patients with sepsis. Continuous dialysis modalities are indicated in hemodynamically unstable patients with severe sepsis, septic shock and acute renal injury. Continuous veno-venous hemodiafiltration with the modified AN69ST membrane provides homeostasis of the immune system's response to bacterial infection, hemodynamic stability of the patient, improved kidney function and a higher survival rate for patients with septic shock and acute renal failure.



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