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Vojnosanitetski pregled
2017, vol. 74, br. 3, str. 232-240
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 09/03/2017
doi: 10.2298/VSP150816108O
Creative Commons License 4.0
Prognostička vrednost paratireoidnog hormona u serumu kod bolesnika sa infarktom miokarda sa elevacijom ST segmenta
aVojnomedicinska akademija, Klinika za urgentnu internu medicinu, Beograd + Univerzitet odbrane, Medicinski fakultet Vojnomedicinske akademije, Beograd
bVojnomedicinska akademija, Klinika za urgentnu internu medicinu, Beograd
cKlinički centar Srbije, Klinika za kardiologiju, Beograd
dUniverzitet u Beogradu, Medicinski fakultet, Institut za medicinsku statistiku i informatiku
eVojnomedicinska akademija, Institut za medicinsku biohemiju, Beograd
fVojnomedicinska akademija, Klinika za neurologiju, Beograd + Univerzitet odbrane, Medicinski fakultet Vojnomedicinske akademije, Beograd

Sažetak

Uvod/Cilj. Paratireoidni hormon (PTH) značajan je glasnik u regeneracionim procesima i može uticati na ishod kod bolesnika sa infarktom miokarda sa ST elevacijom (STEMI). Cilj ovog rada bio je da se ispita uloga PTH u poređenju sa drugim uobičajenim markerima za predviđanje srčane slabosti kod bolesnika sa STEMI. Metode. Kod 165 bolesnika sa STEMI, lečenih primarnom perkutanom koronarnom intervencijom, prva tri dana hospitalizacije merene su vrednosti u serumu: PTH, Btipa natriuretskog peptida (BNP), kreatin-kinaze miokarda (CK-MB), C-reaktivnog proteina (CRP) i glikemije na prijemu, te je ispitivan uticaj na primarni ishod - epizode akutne srčane slabosti u periodu od šest meseci. Rezultati. Površina ispod ROC krive bila je najveća u poređenju sa ostalim markerima (0,867 vs 0,835 vs 0,832 vs 0,627 vs 0,619), za PTH, CRP, BNP, CK-MB i glikemiju na prijemu za predviđanje primarnog ishoda. Maksimalna vrednost PTH imala je nezavisnu vrednost predviđanja za primarni ishod (p < 0,001). Zaključak. Serumske koncentracije PTH u ranoj fazi STEMI mogu predvideti epizode akutne srčane slabosti u prvih šest meseci kod bolesnika lečenih primarnom perkutanom koronarnom intervencijom.

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