Metrika članka

  • citati u SCindeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[=>]
  • posete u poslednjih 30 dana:2
  • preuzimanja u poslednjih 30 dana:2
članak: 9 od 16  
Back povratak na rezultate
Srce i krvni sudovi
2017, vol. 36, br. 1, str. 21-26
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 06/07/2018
doi: 10.5937/siks1701021D
Relationship between age and clinical and laboratory features at admission in patients with pulmonary embolism
(naslov ne postoji na srpskom)
aVojnomedicinska akademija, Klinika za urgentnu internu medicinu, Beograd
bVojnomedicinska akademija, Institut za medicinsku biohemiju, Beograd
cInstitut za plućne bolesti, Sremska Kamenica
dKlinički centar Niš, Klinika za kardiovaskularne bolesti



(ne postoji na srpskom)
Objective. The relation between age and clinical presentation of pulmonary embolism (PE) is not investigated in details. Methods. One hundred and seventy two consecutive patients with PE treated in the period of five years in the single center were enrolled in this study. According to age, patients were divided into tertiles, I ≤ 54 years, II 54-70 years and III > 70 years. Patients' characteristics, Wells score, risk distribution, basic symptoms, ECG signs, laboratory markers at admission and six-month outcome were compared between tertiles of age. Results. Patients in the third tertile were more often women, and had suffered more from common comorbidities. In the first tertile males and smokers predominated; patients had lower BMI and more frequently positive family history for venous thromboembolism. In the third tertile of age fewer patients were presented as a high probability Wells score and more patients could be classified as high-risk patients. Among ECG signs in the multivariant analysis only atrial fibrillation were significantly associated with advance age. Admission glycaemia, brain natriuretic peptide and d-dimers significantly increased and arterial oxygen pressure decreased across the tertiles no matter the presence of comorbidities which may have strong influence. The overall six-month mortality and major bleeding were not significantly different across the tertiles in whole group, but if we excluded patients with malignant disease, mortality rate was highest in the third tertile of age. Conclusion. In patients with PE there are several important differences in clinical presentation of PE which may have important influence on diagnostic procedures, therapy and outcome.

Ključne reči


Castelli, R., Bucciarelli, P., Porro, F., Depetri, F., Cugno, M. (2014) Pulmonary embolism in elderly patients: Prognostic impact of the Cumulative Illness Rating Scale (CIRS) on short-term mortality. Thrombosis Research, 134(2): 326-330
Cefalo, P., Weinberg, I., Hawkins, B.M., Hariharan, P., Okechukwu, I., Parry, B.A., Chang, Y., Rosovsky, R., Liu, S.W., Jaff, M.R., Kabrhel, C. (2015) A Comparison of Patients Diagnosed With Pulmonary Embolism Who Are ≥65 Years With Patients <65 Years. American Journal of Cardiology, 115(5): 681-686
Coutance, G., le Page, O., Lo, T., Hamon, M. (2008) Prognostic value of brain natriuretic peptide in acute pulmonary embolism. Critical Care, 12(4): R109
di Nisio, M., Ageno, W., Rutjes, A.W., Pap, A.F., Büller, H.R. (2015) Risk of major bleeding in patients with venous thromboembolism treated with rivaroxaban or with heparin and vitamin K antagonists. Thromb Haemost, 115(2)
Eichinger, S., Evers, J.L.H., Glasier, A., la Vecchia, C., Martinelli, I., Skouby, S., Somigliana, E., Baird, D.T., Benagiano, G., Crosignani, P.G., Gianaroli, L., Negri, E., Volpe, A., Glasier, A., Crosignani, P.G. (2013) Venous thromboembolism in women: a specific reproductive health risk. Human Reproduction Update, 19(5): 471-482
Fitzmaurice, D., Galiè, N., Gibbs, J.S., Huisman, M.V., Humbert, M., Kucher, N., Lang, I., Lankeit, M., Lekakis, J., Maack, C., Mayer, E., Meneveau, N., Perrier, A., Pruszczyk, P., Rasmussen, L.H., Schindler, T.H., Svitil, P., Noordegraaf, V.A., Zamorano, J.L. (2014) 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J, 35(43): 3030-80
Gong, X., Duan, Z., Yuan, Y. (2015) Long term prognosis and related factors towards patients with acute pulmonary embolism. Int J Clin Exp Med., 8(5): 7906-13
Keller, K., Beule, J., Coldewey, M., Dippold, W., Balzer, J.O. (2015) Impact of advanced age on the severity of normotensive pulmonary embolism. Heart and Vessels, 30(5): 647-656
Kokturk, N., Oguzulgen, I., Demir, N., Demirel, K., Ekim, N. (2005) Differences in Clinical Presentation of Pulmonary Embolism in Older vs Younger Patients. Circulation Journal, 69(8): 981-986
Laporte, S., Mismetti, P., Décousus, H., Uresandi, F., Otero, R., Lobo, J.L., Monreal, M. (2008) Clinical Predictors for Fatal Pulmonary Embolism in 15 520 Patients With Venous Thromboembolism. Circulation, 117(13): 1711-1716
le Gal, G., Righini, M., ROY, P.-M., Meyer, G., Aujesky, D., Perrier, A., Bounameaux, H. (2005) Differential value of risk factors and clinical signs for diagnosing pulmonary embolism according to age. Journal of Thrombosis and Haemostasis, 3(11): 2457-2464
Majeed, A., Goldhaber, S.Z., Kakkar, A., Kearon, C., Eriksson, H., Kreuzer, J., Feuring, M., Hantel, S., Friedman, J., Schellong, S., Schulman, S. (2015) Bleeding events with dabigatran or warfarin in patients with venous thromboembolism. Thromb Haemost, 115(2)
Nauffal, D., Ballester, M., Reyes, R., Jiménez, D., Otero, R., Quintavalla, R., Monreal, M. (2012) Influence of recent immobilization and recent surgery on mortality in patients with pulmonary embolism. Journal of Thrombosis and Haemostasis, 10(9): 1752-1760
Obradovic, S., Dzudovic, B., Rusovic, S., Subota, V., Obradovic, D. (2015) Gender related differences inclinical presentation, electrocardiography signs, laboratory markers and outcome in patients with acute pulmonary embolism. Vojnosanit Pregl First Online
Pollack, C.V., Schreiber, D., Goldhaber, S.Z., i dr. (2011) Clinical characteristics, management, and outcomes of patients diagnosed with acute pulmonary embolismin the emergency department: initial report of EMPEROR (Multicentar Emergency Medicine Pulmonary Embolism in the Real World registry). J Am Coll Cardiol, 57(6); 700-6
Punukollu, H., Khan, I.A., Punukollu, G., Gowda, R.M., Mendoza, C., Sacchi, T.J. (2005) Acute pulmonary embolism in elderly: clinical characteristics and outcome. International Journal of Cardiology, 99(2): 213-216
Righini, M., ROY, P.-M., Meyer, G., Verschuren, F., Aujesky, D., le Gal, G. (2011) The Simplified Pulmonary Embolism Severity Index (PESI): validation of a clinical prognostic model for pulmonary embolism. Journal of Thrombosis and Haemostasis, 9(10): 2115-2117
Sakuma, M., Nakamura, M., Yamada, N., Ota, S., Shirato, K., Nakano, T., Ito, M., Kobayashi, T. (2009) Deep vein thrombosis with pulmonary embolism, deep vein thrombosis alone, and pulmonary embolism alone. Circ J, 73: 305-9
Scherz, N., Labarere, J., Aujesky, D., Mean, M. (2012) Elevated Admission Glucose and Mortality in Patients With Acute Pulmonary Embolism. Diabetes Care, 35(1): 25-31
Schouten, H.J., Geersing, G., Oudega, R., van Delden, J.J.M., Moons, K.G.M., Koek, H.L. (2014) Accuracy of the Wells Clinical Prediction Rule for Pulmonary Embolism in Older Ambulatory Adults. Journal of the American Geriatrics Society, 62(11): 2136-2141
Søgaard, K.K., Schmidt, M., Pedersen, L., Horváth-Puhó, E., Sørensen, H.T. (2014) 30-Year Mortality After Venous Thromboembolism. Circulation, 130(10): 829-836
Torbicki, A., Galié, N., Covezzoli, A., Rossi, E., de Rosa, M., Goldhaber, S.Z. (2003) Right heart thrombi in pulmonary embolism. Journal of the American College of Cardiology, 41(12): 2245-2251
Tsai, J., Grosse, S.D., Grant, A.M., Reyes, N.L., Hooper, W., Atrash, H.K. (2012) Correlates of In-Hospital Deaths among Hospitalizations with Pulmonary Embolism: Findings from the 2001−2008 National Hospital Discharge Survey. PLoS one, 7(7): e34048
Venetz, C., Jiménez, D., Méan, M., Aujesky, D. (2011) A comparison of the original and simplified Pulmonary Embolism Severity Index. Thrombosis and Haemostasis, 106(09): 423-428
Wells, P.S., Anderson, D.R., Rodger, M., Stiell, I., Dreyer, J.F., Barnes, D., Forgie, M., Kovacs, G., Ward, J., Kovacs, M.J. (2001) Excluding pulmonary embolism at the bedside without diagnostic imaging: Management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer. Ann Intern Med, 135(2): 98-107
Zhang, N.F., Zhou, Y.M., Yang, X.Y., Tang, C.L., Wu, H., Zhong, N.S. (2010) Clinical characteristics and prognostic factors of pulmonary embolism in different age groups. Zhonghua Jie He He Hu Xi Za Zhi., 33(6); 436-40
Zöller, B., Li, X., Sundquist, J., Sundquist, K. (2011) Age- and Gender-Specific Familial Risks for Venous Thromboembolism. Circulation, 124(9): 1012-1020
Zöller, B., Li, X., Ohlsson, H., Ji, J., Sundquist, J., Sundquist, K. (2015) Family history of venous thromboembolism as a risk factor and genetic research tool. Thrombosis and Haemostasis, 114(11): 890-900