Metrika članka

  • citati u SCindeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[=>]
  • posete u poslednjih 30 dana:6
  • preuzimanja u poslednjih 30 dana:6
članak: 3 od 4  
Back povratak na rezultate
Vojnosanitetski pregled
2016, vol. 73, br. 12, str. 1094-1101
jezik rada: engleski
vrsta rada: izvorni naučni članak
doi:10.2298/VSP150510134D

Creative Commons License 4.0
Psorijaza jeste nezavisni faktor rane ateroskleroze - prospektivna studija kardiometaboličkog rizika
aVojnomedicinska akademija
bClinic of Dermatology and Venereology, Military Medical Academy, Belgrade + Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade
cFaculty of Medicine of the Military Medical Academy, University of Defence, Belgrade + Clinic of Endocrinology, Military Medical Academy, Belgrade
dFaculty of Medicine of the Military Medical Academy, University of Defence, Belgrade + Clinic of Nephrology, Military Medical Academy, Belgrade
eFaculty of Medicine of the Military Medical Academy, University of Defence, Belgrade + Clinic of Cardiology, Military Medical Academy, Belgrade
fClinic of Nephrology, Military Medical Academy, Belgrade
gFaculty of Medicine of the Military Medical Academy, University of Defence, Belgrade + Institute of Biochemistry, Military Medical Academy, Belgrade

e-adresa: lkandolfsekulovic@gmail.com

Sažetak

Uvod/Cilj. Psorijaza kao multisistemska inflamatorna bolest u vezi je sa povećanim kardiometaboličkim rizikom. Cilj rada bio je da se analiziraju biomarkeri rizika, ultrasonografske odlike perifernih i renalnih arterija, kao i ehoskardiografski podaci kod 106 ispitanika (66 obolelih od psorijaze i 40 kontrolnih ispitanika 20 obolelih od ekcema i 20 zdravih dobrovoljaca). Metode. Kod svih ispitanika analizirani su sledeći parametri: indeks telesne mase (ITM), C-reaktivni protein, D-dimer, serumski amiloid A (SAA), apolipoprotein (Apo) A1, ApoB, ApoB/Apo A1 odnos, jutarnja glikemija, bazalna insu-linemija, C-peptid, homeostaticmodel assessment-insulin resistance (HOMA-IR), HOMA-β -ćelija, serumska mokraćna kiselina (SMK), 24-h proteinurija i mikroalbuminurija; učinjeni su ultrasonografija karotidne, brahijalne, femoralne i renalnih arterija, kao i ehokardiografija. Rezultati. Pet od 66 (7,6%) bolesnika sa psorijazom ispunjavalo je kriterijume za metabolički sindrom (nije registrovan u kontrolnim grupama). Sledeće varijable bile su povećane kod obolelih od psorijaze u poređenju sa obe kontrolne grupe: ITM (p = 0,012), insulinemija (p < 0,001), HOMA-IR (p = 0,003), HOMA-β ćelija (p < 0,001), SMK (p = 0,006), ApoB/ApoA1 odnos (p = 0,006) i mikroal­buminurija (p < 0,001). Takođe, povećane koncentracije C-peptida (p = 0,034), D-dimera (p = 0,029), triglicerida (p = 0,044), SAA (p = 0,005) kao i snižena koncentracija ApoA1 (p = 0,014) nađeni su kod obolelih od psorijaze u poređenju sa zdravim kontrolním ispitanicima. HDL holesterol bio je snižen kod obolelih od psorijaze u poređenju sa kontrolnom grupom obolelih od ekcema (p = 0,004). Debljina intime-medije karotidne i femoralne arterije bila je značajno veća (p < 0,001), a maksimalna brzina protoka (cm/s) u brahijalnoj arteriji bila je značajno manja (p = 0,017) kod obolelih od psorijaze nego kod ispitanika obe kontrolne grupe. Multivarijantna regresiona analiza pokazala je da ga posle prilagođavanja za pridružene varijable, najznačajniji prediktor za debljinu intime-medije karotidne i femoralne arterije sama psorijaza (p < 0,001). Zaključak. Kardiometabolički biomarkeri rizika i ultrasonografski znaci rane ateroskleroze u vezi su sa postojećom psorijazom, a ne sa generalizovanim ekcemom. Nađeno je da je psorijaza nezavisan faktor rizika od supkliničke ateroskleroze.
Za ovaj članak postoji povezani rad (ispravka, opoziv ili komentar) koji je dostupan ovde.

Ključne reči

Reference

Akhyani, M., Ehsani, A.H., Robati, R.M., Robati, A.M. (2007) The lipid profile in psoriasis: a controlled study. Journal of the European Academy of Dermatology and Venereology, 21(10): 1330-2
Albareda, M., Ravella, A., Castelló, M., Saborit, S., Peramiquel, L., Vila, L. (2014) Metabolic syndrome and its components in patients with psoriasis. SpringerPlus, 3(1): 612
Alberti, K.G., Zimmet, P.Z. (1998) Definition, diagnosis and classification of diabetes mellitus and its complications, Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med, 15(7): 539-53
Amin, T., Saied, E., Abdou, S.H. (2005) Atherosclerotic risk in psoriasis. J Pan-Arab League Dermatol, 16(2); 39-45
Armstrong, A.W., Harskamp, C.T., Armstrong, E.J. (2013) Psoriasis and metabolic syndrome: a systematic review and meta-analysis of observational studies. Journal of the American Academy of Dermatology / J. Am. Acad. Dermatol., 68(4): 654-62
Asha, K., Sharma, S.B., Singal, A., Aggarwal, A. (2014) Association of carotid intima-media thickness with leptin and apoliprotein b/apoliprotein a-I ratio reveals imminent predictors of subclinical atherosclerosis in psoriasis patients. Acta medica (Hradec Kralove) / Acta Medica (Hradec Kralove), 57(1): 21-7
Aurangabadkar, S. (2013) Comorbidities in psoriasis. Indian Journal of Dermatology, Venereology, and Leprology, 79(7): 10
Bajaj, D.R., Mahesar, S.M., Devrajani, B.R., Iqbal, M.P. (2009) Lipid profile in patients with psoriasis presenting at Liaquat University Hospital Hyderabad. J Pak Med Assoc, 59(8); 512-5
Balkau, B., Charles, M.A. (1999) Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet Med, 16(5): 442-3
Biyik, I., Narin, A., Bozok, M., Ergene, O. (2006) Echocardiographic and Clinical Abnormalities in Patients with Psoriasis. Journal of International Medical Research, 34(6): 632-639
Boehncke, S., Thaci, D., Beschmann, H., Ludwig, R.J., Ackermann, H., Badenhoop, K., Boehncke, W. (2007) Psoriasis patients show signs of insulin resistance. British journal of dermatology / Br. J. Dermatol., 157(6): 1249-51
Boehncke, W., Boehncke, S., Tobin, A., Kirby, B. (2011) The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity. Experimental dermatology / Exp. Dermatol., 20(4): 303-7
Cameron, A.J., Shaw, J.E., Zimmet, P.Z. (2004) The metabolic syndrome: Prevalence in worldwide populations. Endocrinol Metab Clin North Am, 33(2): 351-75
Cassano, N., Vestita, M., Panaro, M., Carbonara, M., Vena, G.A. (2011) Renal function in psoriasis patients. Eur J Dermatol, 21(2); 264-5
Chodorowska, G., Wojnowska, D., Juszkiewicz-Borowiec, M. (2004) C-reactive protein and alpha2-macroglobulin plasma activity in medium-severe and severe psoriasis. Journal of the European Academy of Dermatology and Venereology, 18(2): 180-3
Choudhury, R. P., Leyva, F. (1999) C-Reactive Protein, Serum Amyloid A Protein, and Coronary Events. Circulation, 100(15): e65-e65
Coimbra, S., Oliveira, H., Reis, F., Belo, L., Rocha, S., Quintanilha, A., Figueiredo, A., Teixeira, F., Castro, E., Rocha-Pereira, P., Santos-Silva, A. (2009) Circulating levels of adiponectin, oxidized LDL and C-reactive protein in Portuguese patients with psoriasis vulgaris, according to body mass index, severity and duration of the disease. Journal of dermatological science / J. Dermatol. Sci., 55(3): 202-4
Dervisoglu, E., Akturk, A.S., Yildiz, K., Kiran, R., Yilmaz, A. (2012) The spectrum of renal abnormalities in patients with psoriasis. International urology and nephrology / Int Urol Nephrol, 44(2): 509-14
Detection, E.P.on, Adults and Treatment of High Blood Cholesterol (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA: The Journal of the American Medical Association, 285(19): 2486-2497
Dogan, S., Atakan, N. (2010) Is serum amyloid A protein a better indicator of inflammation in severe psoriasis?. British journal of dermatology / Br. J. Dermatol., 163(4): 895-6
El-Mongy, S., Fathy, H., Abdelaziz, A., Omran, E., George, S., Neseem, N., El-Nour, N. (2010) Subclinical atherosclerosis in patients with chronic psoriasis: a potential association. Journal of the European Academy of Dermatology and Venereology, 24(6): 661-6
Essiarab, F., Taki, H., Lebrazi, H., Derouiche, A., Kettani, A., Sabri, M., Saile, R., Essiarab, F., Taki, H., Lebrazi, H., Derouiche, A., Kettani, A., Sabri, M., Saile, R. (2014) Inflammation and cardiovascular risk assessment in Moroccan obese patients with and without metabolic syndrome: importance of lipoproteins ratios. Ethnicity & disease / Ethn Dis, 24(4): 462-8
Frank, P.G., Marcel, Y.L. (2000) Apolipoprote in A-I: structurefunction relationships. J Lipid Res, 41(6); 853-72
Gelfand, J.M., Neimann, A.L., Shin, D.B., Wang, X., Margolis, D.J., Troxel, A.B. (2006) Risk of myocardial infarction in patients with psoriasis. JAMA / JAMA, 296(14): 1735-41
Gonzalez-Juanatey, C., Amigo-Diaz, E., Miranda-Filloy, J.A., Testa, A., Revuelta, J., Garcia-Porrua, C., Martin, J., Llorca, J., Gonzalez-Gay, M.A. (2006) Lack of Echocardiographic and Doppler Abnormalities in Psoriatic Arthritis Patients Without Clinically Evident Cardiovascular Disease or Classic Atherosclerosis Risk Factors. Seminars in Arthritis and Rheumatism, 35(5): 333-339
Grzybowski, G., Fafara, I., Zaba, R., Wierusz-Wysocka, B. (2001) Evaluation of glucose, insulin, C-peptide uric acid serum levels in patients with psoriasis. Polski merkuriusz lekarski, 11(66): 495-8
Hamminga, E.A., van der Lely, A.J., Neumann, H.A.M., Thio, H.B. (2006) Chronic inflammation in psoriasis and obesity: Implications for therapy. Medical Hypotheses, 67(4): 768-773
Javidi, Z., Meibodi, N., Nahidi, Y. (2007) Serum lipids abnormalities and psoriasis. Indian Journal of Dermatology, 52(2): 89
Jensen, P., Zachariae, C., Hansen, P., Skov, L. (2011) Normal Endothelial Function in Patients with Mild-to-Moderate Psoriasis: A Case-control Study. Acta Dermato Venereologica, 91(5): 516-520
Karoli, R., Fatima, J., Shukla, V., Dhillon, K.S., Khanduri, S., Maini, S., Chandra, A. (2013) A study of cardio-metabolic risk profile in patients with psoriasis. Journal of the Association of Physicians of India / J Assoc Physicians India, 61(11): 798-803
Kural, B.V., Örem, A., Çimşit, G., Yandı, Y.E., Calapoǧlu, M. (2003) Evaluation of the atherogenic tendency of lipids and lipoprotein content and their relationships with oxidant–antioxidant system in patients with psoriasis. Clinica Chimica Acta, 328(1-2): 71-82
Lowes, M.A., Kikuchi, T., Fuentes-Duculan, J., Cardinale, I., Zaba, L.C., Haider, A.S., Bowman, E.P., Krueger, J.G. (2008) Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells. Journal of Investigative Dermatology, 128(5): 1207-1211
Marongiu, F., Sorano, G.G., Bibbò, C., Pistis, M.P., Conti, M., Mulas, P., Balestrieri, A., Biggio, P. (1994) Abnormalities of blood coagulation and fibrinolysis in psoriasis. Dermatology (Basel, Switzerland) / Dermatology (Basel), 189(1): 32-7
Meigs, J.B., Wilson, P.W.F., Fox, C.S., Vasan, R.S., Nathan, D.M., Sullivan, L.M., D`Agostino, R.B. (2006) Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. Journal of clinical endocrinology and metabolism, 91(8): 2906-12
Menter, A., Gottlieb, A., Feldman, S.R., van Voorhees, A.S., Leonardi, C.L., Gordon, K.B., Lebwohl, M., Koo, J.Y.M., Elmets, C.A., Korman, N.J., Beutner, K.R., Bhushan, R. (2008) Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. Journal of the American Academy of Dermatology / J. Am. Acad. Dermatol., 58(5): 826-50
Moller, D.E., Kaufman, K.D. (2005) Metabolic Syndrome: A Clinical and Molecular Perspective. Annual Review of Medicine, 56(1): 45-62
Naldi, L., Chatenoud, L., Linder, D., Fortina, A.B., Peserico, A., Virgili, A.R., Bruni, P.L., Ingordo, V., Scocco, G.L., Solaroli, C., Schena, D., Barba, A., di Landro, A., Pezzarossa, E. (2005) Cigarette Smoking, Body Mass Index, and Stressful Life Events as Risk Factors for Psoriasis: Results from an Italian Case–Control Study. Journal of Investigative Dermatology, 125(1): 61-67
Neimann, A.L., Shin, D.B., Wang, X., Margolis, D.J., Troxel, A.B., Gelfand, J.M. (2006) Prevalence of cardiovascular risk factors in patients with psoriasis. Journal of the American Academy of Dermatology / J. Am. Acad. Dermatol., 55(5): 829-35
Ohtsuka, T. (2008) The relation between high-sensitivity C-reactive protein and maximum body mass index in patients with psoriasis. British journal of dermatology / Br. J. Dermatol., 158(5): 1141-3
Pietrzak, J., Chodorowska, G. (2010) Psoriasis and serum lipid abnormalities. Derma. tol Ther, 23(2): 160-73
Reich, K. (2012) The concept of psoriasis as a systemic inflammation: implications for disease management. Journal of the European Academy of Dermatology and Venereology, 26: 3-11
Reynoso-von, D.C., Martínez-Abundis, E., Balcázar-Muñoz, B.R., Bustos-Saldaña, R., González-Ortiz, M. (2003) Lipid profile, insulin secretion, and insulin sensitivity in psoriasis. Journal of the American Academy of Dermatology / J. Am. Acad. Dermatol., 48(6): 882-5
Rocha-Pereira, P., Santos-Silva, A., Rebelo, I., Figueiredo, A., Quintanilha, A., Teixeira, F. (2001) Dislipidemia and oxidative stress in mild and in severe psoriasis as a risk for cardiovascular disease. Clinica Chimica Acta, 303(1-2): 33-39
Schiffrin, E.L. (2002) Beyond blood pressure: the endothelium and atherosclerosis progression*. American Journal of Hypertension, 15(S5): 115S-122S
Sergeant, A., Makrygeorgou, A., Chan, W.C., Thorrat, A., Burden, D., Walker, S.L., Kahawita, I. (2008) C-reactive protein in psoriasis. British journal of dermatology / Br. J. Dermatol., 158(2): 417-9
Shapiro, J., Cohen, A.D., Weitzman, D., Tal, R., David, M. (2012) Psoriasis and cardiovascular risk factors: a case-control study on inpatients comparing psoriasis to dermatitis. Journal of the American Academy of Dermatology / J. Am. Acad. Dermatol., 66(2): 252-8
Shirai, K. (2004) Obesity as the core of the metabolic syndrome and the management of coronary heart disease. Current medical research and opinion / Curr Med Res Opin, 20(3): 295-304
Sommer, D.M., Jenisch, S., Suchan, M., Christophers, E., Weichenthal, M. (2006) Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Archives of dermatological research / Arch. Dermatol. Res., 298(7): 321-8
Sterry, W., Strober, B.E., Menter, A., on behalf of the International Psoriasis Council (2007) Obesity in psoriasis: the metabolic, clinical and therapeutic implications. Report of an interdisciplinary conference and review. British Journal of Dermatology, 157(4): 649-655
Strober, B., Teller, C., Yamauchi, P., Miller, J.L., Hooper, M., Yang, Y., Dann, F. (2008) Effects of etanercept on C-reactive protein levels in psoriasis and psoriatic arthritis. British journal of dermatology / Br. J. Dermatol., 159(2): 322-30
Su, V.Y., Chen, T., Yeh, C., Chou, K., Hung, M., Chu, S., Su, K., Chang, Y., Lin, Y., Liu, C. (2014) Atopic dermatitis and risk of ischemic stroke: a nationwide population-based study. Annals of medicine / Ann. Med., 46(2): 84-9
Viazzi, F., Leoncini, G., Derchi, L.E., Pontremoli, R. (2014) Ultrasound Doppler renal resistive index: a useful tool for the management of the hypertensive patient. Journal of hypertension / J. Hypertens., 32(1): 149-53
Wakkee, M., Thio, H.B., Prens, E.P., Sijbrands, E.J.G., Neumann, H.A.M. (2007) Unfavorable cardiovascular risk profiles in untreated and treated psoriasis patients. Atherosclerosis / Atherosclerosis, 190(1): 1-9
Wallace, T.M., Levy, J.C., Matthews, D.R. (2004) Use and abuse of HOMA modeling. Diabetes care / Diabetes Care, 27(6): 1487-95
Wan, J., Wang, S., Haynes, K., Denburg, M. R., Shin, D. B., Gelfand, J. M. (2013) Risk of moderate to advanced kidney disease in patients with psoriasis: population based cohort study. BMJ, 347(oct15 7): f5961-f5961
Wannamethee, S. G., Shaper, A. G., Lennon, L., Morris, R.W. (2005) Metabolic Syndrome vs Framingham Risk Score for Prediction of Coronary Heart Disease, Stroke, and Type 2 Diabetes Mellitus. Archives of Internal Medicine, 165(22): 2644
Wellen, K.E., Hotamisligil, G.S. (2005) Inflammation, stress, and diabetes. Journal of Clinical Investigation, 115(5): 1111-1119
Yang, Y., Keller, J.J., Lin, H. (2011) Medical comorbidity associated with psoriasis in adults: a population-based study. British journal of dermatology / Br. J. Dermatol., 165(5): 1037-43