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Vojnosanitetski pregled
2017, vol. 74, iss. 10, pp. 954-962
article language: English
document type: Original Scientific Paper
doi:10.2298/VSP151216270I

Creative Commons License 4.0
Etiology and resistance patterns of bacteria causing ventilator-associated pneumonia in a respiratory intensive care unit
aHemofarm AD, Research and Development Department, Belgrade
bInstitute of Lung Diseases
cInstitute for Pulmonary Diseases of Vojvodina, Clinic for Urgent Pulmonology, Intensive Care Unit, Sremska Kamenica + University of Novi Sad, Faculty of Medicine, Novi Sad
dUniverzitet u Beogradu, Medicinski fakultet, Institut za medicinsku statistiku i informatiku
eUniversity of Kragujevac, Faculty of Medicine

e-mail: vlada.cekic@yahoo.com

Abstract

Background/Aim. Ventilator-associated pneumonia (VAP) incidence, causative pathogens, and resistance patterns are different among countries and intensive care units (ICUs). In Europe, resistant organisms have progressively increased in the last decade. However, there is a lack of data from Serbian ICUs. The aims of this study were to evaluate etiology and antimicrobial resistance for pathogens causing VAP in ICU patients, to examine whether there were differences among pathogens in early-onset and late-onset VAP and to identify mortality in patients with VAP after 30 and 60 days of hospitalization. Methods. A retrospective cohort study was conducted in the respiratory ICU and all adult patients diagnosed with VAP from 2009 to 2014 were included. Results. Gram negative organisms were the major pathogens (80.3%). The most commonly isolated was Acinetobacter spp (59.8%). There was a statistically significant increase in the incidence of infection with Klebsiella pneumoniae (8.9% vs 25.6%; p = 0.019). Extensively drugresistant strains (XDR) were the most common (78.7%). Lateonset VAP was developed in 81.1% of patients without differences among pathogens in comparison with early-onset VAP. Acinetobacter spp was susceptible to tigecycline and colistin with a significant increase in resistance to ampicillin/sulbactam (30.2% vs 58.6%; p = 0.01). Resistance rate of Pseudomonas aeruginosa and Klebsiella pneumoniae to carbapenems was 38% and 11%, respectively. In methicillin-resistant Staphylococcus aureus no resistance was observed against vancomycin and linezolid. There was no difference in mortality rate between patients with earlyonset and late-onset VAP after 30 and 60 days of hospitalization. Conclusion. Gram negative organisms were the primary cause of bacterial VAP of which the most common was the XDR strain of Acinetobacter spp. Patients with early- and late-onset VAP had the same pathogens. There was no difference in mortality between this two group of patients during 60 days of hospitalization.

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References

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