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Acta Facultatis Medicae Naissensis
2007, vol. 24, iss. 3, pp. 165-169
article language: English
document type: Original Scientific Paper
published on: 28/02/2008
Lipid peroxidation and total SH group in patients with different forms of glomerulonephritis
aUniveristy of Niš, Faculty of Medicine, Institute of Biochemistry + Clinical Centre Niš, Clinic of Nephrology
bClinical Centre Niš, Clinic of Nephrology
cUniveristy of Niš, Faculty of Medicine, Institute of Biochemistry

e-mail: tanja_cvetkovic@yahoo.co.uk

Abstract

Reactive oxygen species (ROS) are believed to be the most important intracellular signaling molecules involved in the pathogenesis of glomerulonephritis (GN). The aim of this study was to determine the concentration of lipid peroxidation products (TBARS-thiobarbituric acid reactive substances), parameters of oxidative stress in serum and urine, as well as the concentration of serum total SH groups as one of antioxidative parameters in patients with different forms of glomerulonephritis. Our study included 42 patients treated at the Institute of Nephrology and Haemodialysis, Clinical Centre Niš. All patients with various glomerular diseases were divided into four groups: I group (n=8) comprised patients with membranous glomerulonephritis (MN). II group (n=12) comprised patients with IgA nephropathy (IgA), while III group (n=10) recruited patients with lupus nephropathy (SLE). In the control group (IV group), there were 11 healthy subjects. The obtained results indicate that the level of TBARS in serum and urine patients with MN glomerulopathy was significantly decreased, while the concentration of total SH group was significantly increased compared to the control group. Linear correlation between TBARS as well as SH groups and creatinine clearance were established. Great importance of studying the role of oxidative stress for the onset of the illness or its complications in different forms of glomerulonephritis lies in the possibility of administration of antioxidants in the sense of therapeutic support and damage decrease.

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References

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