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Acta medica Medianae
2006, vol. 45, iss. 2, pp. 16-19
article language: Serbian
document type: Original Scientific Paper
published on: 02/06/2007
Tumors of the kidney and urinary tract in endemic area of village Brestovac: Twenty-five-year retrograde study
aClinical Centre Niš, Clinic of Nephrology
bZdravstvena stanica, Brestovac, Medicinski centar, Leskovac
cSerbian Academy of Sciences and Arts - SASA, Belgrade


During the twenty- five-year period the incidence of urothelial tumors was followed in the endemic village Brestovac. Thirty patients (3 of which with confirmed endemic nephropathy and 15 persons with suspected nephropathy) were investigated. Our retrograde study showed that there is a relationship between endemic nephropathy and urothelial cancer, and this association persisted with marked tendency to rise. Tumors were more common among males, aged from 50 to 70 years, with upper urinary tract urothelial cancer, papillary or trancellular forms, predominantly. Clinical feature showed classic triad of hematuria, flank pain and, rarely, flank mass, accompanied with non-specific symptomatology. Normal renal function was observed in 25 patients, but chronic renal failure was proven in five. Ten patients were treated by surgery, while 20 patients were treated by conservative therapy. There are no marked risk factors.


endemic nephropathy; renal tumor; urinary tract cancer


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