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2012, vol. 62, br. 4, str. 385-401
Metabolizam biogenih amina u akutnoj ishemiji mozga - uticaj sistemske hiperglikemije
aUniverzitet u Beogradu, Medicinski fakultet, Institut za medicinu rada i radiološku zaštitu 'Dr Dragomir Karajović'
bKlinički centar Srbije, Beograd
cUniverzitet u Beogradu, Medicinski fakultet, Institut za rehabilitaciju 'Dr M. Zotović'
dHigh Health School of Professional Studies, Belgrade

e-adresamilalex@eunet.rs
Ključne reči: acute ischaemia; biogenic amines; systemic hyperglycaemia
Sažetak
Efekat ishemije na parenhim mozga zavisi od mnogih faktora, kao što su mehanizam nastalog prekida protoka krvi, brzina nastalog prekida protoka krvi, dužina trajanja ishemične epizode, organizacija anatomskih struktura krvnih sudova mozga itd., što sve utiče na krajnji ishod. Dopamin, noradrenalin i serotonin su biogenic amini koji se ubrajaju u transmitere centralnog nervnog sistema. Pri prekidu moždane cirkulacije u eksperimentalnim ili kliničkim uslovima metabolizam neurotransmitera, u prvom redu biogenih amina, je poremećen. Mnoga istraživanja na raznim eksperimentalnim modelima kompletne ishemije ukazuju na smanjenje sadržaja noradrenalina, dopamina i serotonina u centralnim nervnim tkivima. Dokazano je da hiperglikemija može drastično da poveća cerebralno oštećenje praćeno kratkotrajnom cerebralnom ishemijom. Imajući u vidu činjenicu da biogeni amini (dopamin, noradrenalin i serotonin) neposredno učestvuju u određivanju veličine neurološkog oštećenja i činjenicu da je u stanjima hiperglikemije veličina infarkta (sa morfološkog aspekta) veća u odnosu na normoglikemičnu situaciju, hteli smo da proverimo kolika je uloga biogenih amina u nastajanju oštećenja u stanjima hiperglikemije, odnosno u situacijama pojave apopleksije mozga u dijabetičara. Analizom metabolizma biogenih amina u stanjima akutne i hronične hiperglikemije i efekat reberzibilne i ireverzibilne ishemije mozga na metabolizam serotonina, dopamina i noradrenalina, ustanovljeno je da akutna hipeglikemija usporava metabolizam serotinana, dopamina i noradrenalina u kori mozga i n. caudatus-u. Ishemija mozga u normoglikemičnih životinja po sebi je bez uticaja na metabolizam biogenih amina, ali se efekat ishemije ispoljava u toku recirkulacije. U recirkulaciji, što odgovara događajima u penumbri, oslobađanje biogenih amina je nekontrolisano i pojačano. Ishemija mozga u akutno-hipeglikemičnih životinja povećava oslobađanje biogenih amina nezavisno od dužine trajanja ishemije (5 ili 15 minuta). Ovaj efekat je još više izražen tokom recirkulacije. Akutna hiperglikemija čini moždano tkivo osetljivim već na ishemiju kraćeg trajanja - reverzibilnu ishemiju.
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O članku

jezik rada: engleski
vrsta rada: neklasifikovan
DOI: 10.2298/AVB1204385M
objavljen u SCIndeksu: 22.03.2013.