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Acta Facultatis Medicae Naissensis
2012, vol. 29, br. 2, str. 69-80
jezik rada: engleski
vrsta rada: naučni članak

Virusni miokarditis - dijagnostički i terapijski izazov za lekare
aUniverzitet u Nišu, Medicinski fakultet, Institut za prevenciju, lečenje i rehabilitaciju reumatičkih i kardioloških bolesti 'Niška Banja' - Niška Banja
bInstitute for Treatment and Rehabilitation Niška Banja, Niška Banja + Faculty of Medicine, Niš

e-adresa: drdejan76@gmail.com

Sažetak

Miokarditis se definiše kao zapaljenje srčanog mišića prema kliničkim, imunohistohemijskim i patološkim kriterijumima. Miokarditis se može manifestovati širokim spektrom simptoma od blage dispneje do bola u grudima, a ponekad bez specifične terapije može dovesti do kardiogenog šoka i smrti. Prema podacima, učestalost miokarditisa je 8-10 slučajeva na 100000, a prevalenca na neselektovanim obdukcijama je 1-5 na 100 slučajeva. Najčešći mogući izazivači miokarditisa: koksaki virus B3, parvovirus B19, adenovirusi i humani herpesvirus 6. Patogeneza virusnog miokarditisa prolazi kroz tri faze: akutne virusne infekcije, infiltracije zapaljenskim ćelijama i remodelovanja miokarda. Početna evaluacija bolesnika obuhvata detaljnu istoriju bolesti i pažljiv fizički pregled; u daljem toku treba uraditi elektrokardiogram, rentgen srca i pluća, analize krvi, neinvazivne metode snimanja srca. Dijagnoza miokarditisa može se postaviti samo endomiokardnom biopsijom, uključujući: histologiju, immunohistologiju i molekularnu biologiju ili virusologiju. Terapija se može podeliti na suporativnu i specifičnu terapiju (imunosupresivna terapija, interferon, imunoglobulini, imuno adsorptivna terapija, imuno-modulacija, vakcinacija).

Ključne reči

Reference

Baccouche, H., Mahrholdt, H., Meinhardt, G., Merher, R., Voehringer, M., Hill, S., Klingel, K., Kandolf, R., Sechtem, U., Yilmaz, A. (2009) Diagnostic synergy of non-invasive cardiovascular magnetic resonance and invasive endomyocardial biopsy in troponin-positive patients without coronary artery disease. European heart journal, 30(23): 2869-79
Bowles, N.E., Ni, J., Kearney, D.L., Pauschinger, M., Schultheiss, H., McCarthy, R., Hare, J., Bricker, T.J., Bowles, K.R., Towbin, J.A. (2003) Detection of viruses in myocardial tissues by polymerase chain reaction: Evidence of adenovirus as a common cause of myocarditis in children and adults. Journal of the American College of Cardiology, 42(3): 466-72
Caforio, A.L.P., Calabrese, F., Angelini, A., Tona, F., Vinci, A., Bottaro, S., Ramondo, A., Carturan, E., Iliceto, S., Thiene, G., Daliento, L. (2007) A prospective study of biopsy-proven myocarditis: Prognostic relevance of clinical and aetiopathogenetic features at diagnosis. European heart journal, 28(11): 1326-33
Cooper, L.T., Baughman, K.L., Feldman, A.M., Frustaci, A., Jessup, M., Kuhl, U., Levine, G.N., Narula, J., Starling, R.C., Towbin, J., Virmani, R. (2007) The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease. Journal of the American College of Cardiology, 50(19): 1914-1931
Cooper, L.T., Rader, V., Ralston, N.V.C. (2007) The roles of selenium and mercury in the pathogenesis of viral cardiomyopathy. Congestive heart failure, 13(4): 193-9
Coyne, C.B., Bergelson, J.M. (2006) Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions. Cell, 124(1): 119-31
Frustaci, A., Russo, M.A., Chimenti, C. (2009) Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: The TIMIC study. European heart journal, 30(16): 1995-2002
Gutberlet, M., Spors, B., Thoma, T., Bertram, H., Denecke, T., Felix, R., Noutsias, M., Schultheiss, H., Kühl, U. (2008) Suspected chronic myocarditis at cardiac MR: Diagnostic accuracy and association with immunohistologically detected inflammation and viral persistence. Radiology, 246(2): 401-9
Kindermann, I., Kindermann, M., Kandolf, R., Klingel, K., Bültmann, B., Müller, T., Lindinger, A., Böhm, M. (2008) Predictors of outcome in patients with suspected myocarditis. Circulation, 118(6): 639-48
Kühl, U., Pauschinger, M., Noutsias, M., Seeberg, B., Bock, T., Lassner, D., Poller, W., Kandolf, R., Schultheiss, H. (2005) High prevalence of viral genomes and multiple viral infections in the myocardium of adults with 'idiopathic' left ventricular dysfunction. Circulation, 111(7): 887-93
Kühl, U., Pauschinger, M., Schwimmbeck, P.L., Seeberg, B., Lober, C., Noutsias, M., Poller, W., Schultheiss, H. (2003) Interferon-beta treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction. Circulation, 107(22): 2793-8
Lui, P.P., Schultheiss, H.P. (2007) Myocarditis. u: Braunwald E., Zipes D.P., Libby P. [ur.] The text book of cardiovascular medicine, Philadelphia-Toronto: WB Saundres Company, 1775-92; 8th edition
Magnani, J.W., Danik, J.S.H., Dec, W.G., DiSalvo, T.G. (2006) Survival in biopsy-proven myocarditis: A long-term retrospective analysis of the histopathologic, clinical, and hemodynamic predictors. American heart journal, 151(2): 463-70
Mahfoud, F., Gärtner, B., Kindermann, M., Ukena, C., Gadomski, K., Klingel, K., Kandolf, R., Böhm, M., Kindermann, I. (2011) Virus serology in patients with suspected myocarditis: Utility or futility?. European heart journal, 32(7): 897-903
Mahrholdt, H., Goedecke, C., Wagner, A., Meinhardt, G., Athanasiadis, A., Vogelsberg, H., Fritz, P., Klingel, K., Kandolf, R., Sechtem, U. (2004) Cardiovascular magnetic resonance assessment of human myocarditis: A comparison to histology and molecular pathology. Circulation, 109(10): 1250-8
Mahrholdt, H., Wagner, A., Deluigi, C.C., Kispert, E., Hager, S., Meinhardt, G., Vogelsberg, H., Fritz, P., Dippon, J., Bock-Thomas, C., Klingel, K., Kandolf, R., Sechtem, U. (2006) Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation, 114(15): 1581-90
Maron, B.J., Doerer, J.J., Haas, T.S., Tierney, D.M., Mueller, F.O. (2009) Sudden deaths in young competitive athletes: Analysis of 1866 deaths in the United States, 1980-2006. Circulation, 119, str. 1085-1092
McCarthy, R.E., Boehmer, J.P., Hruban, R.H., Hutchins, G.M., Kasper, E.K., Hare, J.M., Baughman, K.L. (2000) Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis. New England journal of medicine, 342(10): 690-5
McCully, R.B., Cooper, L.T., Schreiter, S. (2005) Coronary artery spasm in lymphocytic myocarditis: A rare cause of acute myocardial infarction. Heart, 91(2): 202
Nugent, A.W., Daubeney, P.E.F., Chondros, P., Carlin, J.B., Cheung, M., Wilkinson, L.C., Davis, A.M., Kahler, S.G., Chow, C.W., Wilkinson, J.L., Weintraub, R.G. (2003) The Epidemiology of Childhood Cardiomyopathy in Australia. New England Journal of Medicine, 348(17): 1639-1646
Schmidt-Lucke, C., Spillmann, F., Bock, T., Kühl, U., van Linthout, S., Schultheiss, H., Tschöpe, C. (2010) Interferon beta modulates endothelial damage in patients with cardiac persistence of human parvovirus b19 infection. Journal of infectious diseases, 201(6): 936-45
Schultheiss, H.P., Kuehl, U. (2010) Cardiovascular viral infections. u: Lennette E.H. [ur.] Lennette's Laboratory Diagnosis of Viral Infections, New York: Informa Healthcare USA Inc, Chapter 18. 304-18; http://dx.doi.org/10.3109/9781420084962.018. 4th ed
Schultheiss, H., Kühl, U., Cooper, L.T. (2011) The management of myocarditis. European heart journal, 32(21): 2616-25
Ukena, C., Mahfoud, F., Kindermann, I., Kandolf, R., Kindermann, M., Bohm, M. (2011) Prognostic electrocardiographic parameters in patients with suspected myocarditis. European Journal of Heart Failure, 13(4): 398-405
Yamauchi-Takihara, K. (2011) What we learned from pandemic H1N1 influenza A. Cardiovascular research, 89(3): 483-4