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Acta veterinaria 2011, vol. 61, br. 5-6, str. 479-488
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Fenotip limfocita periferne krvi u korelaciji sa histološkom slikom štitaste žlezde pacova tretiranih kalijum jodidom
aUniverzitet u Beogradu, Medicinski fakultet bSpecial Hospital for Mental Disorders, Belgrade cUniverzitet u Beogradu, Medicinski fakultet, Institut za mentalno zdravlje dUniverzitet u Beogradu, Medicinski fakultet, Institut za anatomiju
e-adresa: ljmarkovich@med.bg.ac.rs
Projekat
Opticko mikroskopska, imunomorfološka, molekularno-biološka i genetska ispitivanja malignih i nemalignih bolesti bubrega (MPNTR - 175059)
SažetakImajući u vidu ranije rezultate koji su potvrdili povezanost između štitaste žlezde i imunskog sistema, kao i praksu administriranja kalijum jodida u lečenju nekih autoimunih bolesti, smatrali smo da je od naučnog značaja ispitati patogenezu eksperimentalnog tireoiditisa indukovanog kalijum jodidom (KI). Proučavali smo morfologiju timusa, štitaste žlezde, slezine i fenotip T-ćelija (CD4 i CD8) u perifernoj krvi. Eksperimenti su izvedeni na muzjacima Wistar pacova (n=30), nasumično podeljenim u 3 grupe (n=10). Prva grupa je dobila KI (225 μg/g, i.p.), druga grupa je dobila takođe KI (675 μg/g, i.p.), dok je treća grupa bila kontrolna (0.9% NaCl, i.p.). Kalijum jodid je statistički značajno smanjio masu pacova, kao i mase štitastih žlezda (p<0,05). On je takođe izazvao visoko statistički značajne (p<0,01) histološke promene u vidu mononuklearne ćelijske infiltracije (manja doze KI), destrukcije žlezdanih acinusa i proliferacije vezivnog tkiva (veća doza). Kalijum jodid, sa druge strane, nije uticao na broj CD4 i CD8 T-ćelija u timusu i perifernoj krvi (p>0,05). Ovi rezultati ukazuju da KI u određenim dozama indukuje blagi limfocitni tireoiditis, i da ovaj jednostavni i pristupačni model eksperimentalnog tireoiditisa može biti od koristi za dalja istraživanja.
Ključne reči
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