Article metrics

  • citations in SCindeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[=>]
  • visits in previous 30 days:5
  • full-text downloads in 30 days:2
article: 1 from 2  
Back back to result list
Medicinski pregled
2017, vol. 70, iss. 3-4, pp. 99-106
article language: English
document type: Professional Paper
doi:10.2298/MPNS1704099M


Antimicrobial susceptibility pattern of Acinetobacter spp in the period 2012 - 2015
University of Novi Sad, Faculty of Medicine, Department of Infectious Diseases + Clinical Center of Vojvodina, Novi Sad, Clinic of Infectious Diseases

e-mail: sandrastefanm@yahoo.co.uk

Abstract

Introduction. Representatives of the genus Acinetobacter have become an important cause of hospital-acquired infections due to their great ability to survive and spread in a hospital environment, as well as rapid development of resistance to many antibiotics. The aim of this study was to determine the incidence of nosocomial infections caused by Acinetobacter spp among patients hospitalized at the Clinic of Infectious Diseases of the Clinical Center of Vojvodina; determine the presence and prevalence of resistance to antimicrobials in strains Acinetobacter spp, isolated from patient materials routinely sampled at the Clinic of Infectious Diseases of the Clinical Center of Vojvodina in the period January 1, 2012 to December 31, 2015. Material and Methods. A retrospective study included 1.673 patients with infectious diseases of bacterial etiology treated at the Clinic of Infectious Diseases of the Clinical Center of Vojvodina. The analysis of blood cultures, urine, cerebrospinal fluid culture, wound/decubitus swab, throat swabs, cannula/ tube swabs, and bronchial aspirate was performed to establish the incidence of infections caused by Acinetobacter spp and antimicrobial resistance. Results. During the four-year research, Acinetobacter spp was isolated from blood samples in 14/260 (5.4%), urine in 6/198 (3.0%), cerebrospinal fluid in 2/43 (4.7%), wound/decubitus swabs in 33/128 (25.8%), throat swabs in 14/124 (11.3%) cannula/ tube swabs and bronchial aspirate in 32/72 (44.4%) samples. The isolates of Acinetobacter spp showed the highest susceptibility to colistin (100%). Resistance to carbapenems and piperacillin/tazobactam accounted for nearly 100% in all tested isolates, while resistance to other antibiotics was over 63.6%, except to tobramycin whose resistance accounted for 11.1%. Conclusion. Representatives of the genus Acinetobacter are a common cause of nosocomial infections in hospitalized patients. Acinetobacter spp is only sensitive to colistin (100%), while it is resistant in various percentages to all other tested antibiotics.
For this article there is a related paper (correction, retraction, or comment) which is available here.

Keywords

References

*** (2015) Antimicrobial resistance. Geneva: World Health Organization, [updated 2016 Sep; cited 2016 Sept 19]. Available from: http://www.who.int/mediacentre/factsheets/fs194/en
Al, M.S.B., Aly, M.M., Al, humidi N.Q., Halwani, M. (2013) Incidence and prevalence of Acinetobacter baumannii in King Fahd General Hospital, Saudi Arabia. Life Sci J, 10(4): 1702-10
Aucken, H., Berlau, J., Malnick, H., Pitt, T. (1999) Distribution of Acinetobacter Species on Skin of Healthy Humans. European Journal of Clinical Microbiology & Infectious Diseases, 18(3): 179-183
Bassetti, M., Righi, E., Esposito, S., Petrosillo, N., Nicolini, L. (2008) Drug treatment for multidrug-resistant Acinetobacter baumannii infections. Future microbiology, 3(6): 649-60
Bergogne-Bérézin, E., Towner, K.J. (1996) Acinetobacter spp. as nosocomial pathogens: Microbiological, clinical, and epidemiological features. Clin Microbiol Rev, 9(2), str. 148-65
Cisneros, J.M., Rodríguez-Baño, J. (2002) Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment. Clinical microbiology and infection, 8(11): 687-93
Dijkshoorn, L., van Aken, E., Shunburne, L., van der Reijden, T., Bernards, A.T., Nemec, A., Towner, K.J. (2005) Prevalence of Acinetobacter baumannii and other Acinetobacter spp. in faecal samples from non-hospitalised individuals. Clinical Microbiology and Infection, 11(4): 329-332
Doi, Y., Murray, G., Peleg, A. (2015) Acinetobacter baumannii: Evolution of Antimicrobial Resistance-Treatment Options. Seminars in Respiratory and Critical Care Medicine, 36(01): 085-098
European Commission (2009) Assessment of the antibiotic resistance effects of biocides. Brussels: Scientific Committee on Emerging and Newly Identified Health Risks, [cited 2016 Sep 20]. Available from: http://ec.europa.eu/health/ph_risk/committees/04_scenihr/docs/scenihr_o_021.pdf
Gerner-Smidt, P., Tjernberg, I., Ursing, J. (1991) Reliability of phenotypic tests for identification of Acinetobacter species. J Clin Microbiol, 29(2): 277-82
Goić-Barišić, I. (2012) Multiplorezistentni Acinetobacter baumannii (MRAB) - deset godina nakon pojave prvih izolata u Hrvatskoj. Infektološki glasnik, 32(2): 67-70
Hawkey, P., Bergogne-Berezin, E. (2006) Acinetobacter spp. in: Gillespie, Stephen H.; Hawkey, Peter M. [ed.] Principles and Practice of Clinical Bacteriology, Chichester, UK: Wiley-Blackwell, str. 231-244
Hsueh, P., Teng, L., Chen, C., Chen, W., Yu, C., Ho, S., Luh, K. (2002) Pandrug-resistant Acinetobacter baumannii causing nosocomial infections in a university hospital, Taiwan. Emerging infectious diseases, 8(8): 827-32
Jones, M.E., Draghi, D.C., Thornsberry, C., Karlowski, J.A., Sahm, D.F., Wenzel, P.R. (2014) Emerging resistance among bacterial pathogens in the intensive care unit: A European and North American surveillance study (2000-2002). Ann Clin Microbiol Antimicrob, 3: 14
Kallen, Alexander J., Hidron, Alicia I., Patel, J., Srinivasan, A. (2010) Multidrug Resistance among Gram‐Negative Pathogens That Caused Healthcare‐Associated Infections Reported to the National Healthcare Safety Network, 2006-2008. Infection Control and Hospital Epidemiology, 31(5): 528-531
Kim, J.W., Heo, S.T., Jin, J.S., Choi, C.H., Lee, Y.C., Jeong, Y.G., Kim, S., Lee, J.C. (2008) Characterization of Acinetobacter baumannii carrying bla(OXA-23), bla(PER-1) and armA in a Korean hospital. Clinical microbiology and infection, 14(7): 716-8
Medić, D., Mihajlović-Ukropina, M., Gusman, V., Jelesić, Z., Milosavljević, B. (2011) Rezistencija na karbapeneme kod sojeva Acinetobacter spp izolovanih iz briseva rana tokom 2009. i 2010. godine. Medicinski pregled, vol. 64, br. 11-12, str. 583-587
Peleg, A.Y., Seifert, H., Paterson, D.L. (2008) Acinetobacter baumannii: emergence of a successful pathogen. Clinical microbiology reviews, 21(3): 538-82
Popović, R., Kolak, R., Ikonić, N., Tomić, Z., Rakić, G., Šunjkić, A., Božić, T. (2012) Surveillance of antimicrobial resistance at the Clinic of anesthesia and intensive care Clinical center of Vojvodina. Medicina danas, vol. 11, br. 4-6, str. 172-180
Rosić, I., Rosić, N., Simović, S. (2013) Antimicrobial susceptibility pattern of Acinetobacter species isolated from infected wounds at a tertiary care hospital. Racionalna terapija, vol. 5, br. 2, str. 15-26
Seifert, H., Dijkshoorn, L., Gerner-Smidt, P., Pelzer, N., Tjernberg, I., Vaneechoutte, M. (1997) Distribution of Acinetobacter species on human skin: Comparison of phenotypic and genotypic identification methods. J Clin Microbiol, 35(11): 2819-25
Stoeva, T., Higgins, P.G., Bojkova, K., Seifert, H. (2008) Clonal spread of carbapenem-resistant OXA-23-positive Acinetobacter baumannii in a Bulgarian university hospital. Clinical microbiology and infection, 14(7): 723-7
Šuljagić, V., Mirović, V. (2006) Epidemiological characteristics of nosocomial bloodstream infections and their causes. Vojnosanitetski pregled, vol. 63, br. 2, str. 124-131
Tambić, A.A. (2007) Otpornost bakterija na antibiotike - vodeći problem medicine u 21. stoljeću. Medicina, 43: 7-14
Towner, K.J., Levi, K., Vlassiadi, M. (2008) Genetic diversity of carbapenem-resistant isolates of Acinetobacter baumannii in Europe. Clinical Microbiology and Infection, 14(2): 161-167
Unal, S., Garcia-Rodriguez, J.A. (2005) Activity of meropenem and comparators against Pseudomonas aeruginosa and Acinetobacter spp. isolated in the MYSTIC Program, 2002-2004. Diagnostic Microbiology and Infectious Disease, 53(4): 265-271
Viehman, J. A., Nguyen, M. H., Doi, Y. (2014) Treatment Options for Carbapenem-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Infections. Drugs, 74(12): 1315-1333