Metrika članka

  • citati u SCindeksu: [1]
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[=>]
  • posete u poslednjih 30 dana:8
  • preuzimanja u poslednjih 30 dana:1
članak: 1 od 1  
Back povratak na rezultate
Medicinski pregled
2016, vol. 69, br. 3-4, str. 110-114
jezik rada: engleski
vrsta rada: stručni članak
objavljeno: 27/04/2016
doi: 10.2298/mpns1604110D
Osetljivost respiratornih izolata Streptococcus pneumoniae dobijenih iz materijala dece hospitalizovane u Kliničkom centru Niš
aInstitute for Public Health, Niš
bKlinički centar Niš

e-adresa: dinicmarina@gmail.com

Sažetak

Uvod. Streptococcus pneumoniae predstavlja jedan od najčešćih uzročnika infekcija respiratornog trakta. Cilj istraživanja bio je ispitati osetljivost izolata Streptococcus pneumoniae dobijenih iz materijala hospitalizovane dece sa infekcijom respiratornog trakta. Materijal i metode. Istraživanjem je obuhvaćeno 190 pneumokoknih izolata dobijenih iz endotrahealnih aspirata dece uzrasta 0-14 godina. Identifikovanje je izvršeno primenom standardnih mikrobioloških metoda. Primenom diskdifuzione metode ispitivanaje osetljivost na oksacilin, eritromicin, klindamicin, tetraciklin, trimetoprim/sulfametoksazol, ofloksacin i rifampicin. Osetljivost na amoksicilin i ceftriakson ispitivana je određivanjem minimalnih inhibitornih koncentracija primenom E-testa. Fenotip rezistencije na makrolide određivan je primenom duplog disk-testa diskovima eritromicina i klindamicina. Rezultati. Svi izolati bili su osetljivi na amoksicilin i ceftriakson. Minimalna inhibitorna koncentracija amoksicilina koja inhibira rast 50% izolata iznosila je 0,50 μg/ml dok je za 90% izolata iznosila 1 μg/ml. Minimalna inhibitorna koncentracija ceftriaksona koja inhibira rast 50% izolata iznosila je 0,25 μg/ml dok je za 90% izolata iznosila 0,50 μg/ml. Na eritromicin je bilo osetljivo 21,6% a na klindamicin 29,47% izolata. Kod 10,07% izolata detektovana je rezistencija na makrolide - M fenotip, dok je čak 89,93% izolata pokazalo rezistenciju na makrolide, linkozamide i streptogramine (konstitutivni MLS fenotip). Svi ispitivani izolati bili su osetljjivi na ofloksacin i rifampicin. Zaključak. Ampicilin predstavlja lek izbora u empirijskoj terapiji respiratornih infekcija kod dece. U našoj sredini makrolide ne bi trebalo primenjivati u empirijskoj terapiji infekcija izazvanih pneumokokom.

Ključne reči

Reference

Bansal, A., Singhi, S.C., Jayashree, M. (2006) Penicillin and gentamicin therapyvs amoxicillin/clavulanate in severe hypoxemic pneumonia. Indian Journal of Pediatrics, 73(4): 305-309
Clinical and Laboratory Standards Institute (2009) Performance standards for antimicrobial susceptibility testing: Nineteenth informational supplement. Wayne, USA, M100-S19, 29
Doit, C., Loukil, C., Fitoussi, F., Geslin, P., Bingen, E. (1999) Emergence in France of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin. Antimicrob Agents Chemother, 43: 1480-3
Gajić, I., Mijač, V., Ranin, L., Anđelković, D., Radičević, M., Opavski, N. (2013) Invasive isolates of Streptococcus pneumoniae in Serbia: Antimicrobial susceptibility and serotypes. Srpski arhiv za celokupno lekarstvo, vol. 141, br. 1-2, str. 48-53
Garau, J. (2005) Both penicillin and amoxycillin should be tested in antimicrobial surveillance for Streptococcus pneumoniae. Clinical Microbiology and Infection, 11(5): 422-423
Hammerschmidt, S., Paterson, G.K., Bergmann, S., Mitchell, T.J. (2007) Pathogenesis of Streptococcus pneumoniae infections: Adaptive immunity, innate immunity, cell biology, virulence factors. u: Suttorp N., Welte T., Marre R. [ur.] Community-Acquired Pneumonia, Basel: Birkhauser Verlag, p. 139-81
Horvat, O., Mihajlović-Ukropina, M., Mijatović, V., Sabo, A. (2014) Susceptibility of common bacterial respiratory pathogens to antimicrobial agents in outpatients from south Backa District. Medicinski pregled, vol. 67, br. 3-4, str. 71-77
Invasive Bacterial Infection Surveillance (IBIS) group, International Clinical Epidemiology Network (1999) Prospective multicentre hospital surveillance of Streptococcus pneumoniae disease in India. Lancet, 353: 1216-21
Jacobs, M.R. (2003) The Alexander Project 1998-2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents. Journal of Antimicrobial Chemotherapy, 52(2): 229-246
Jones, R.N., Jacobs, M.R., Sader, H.S. (2010) Evolving trends in Streptococcus pneumoniae resistance: implications for therapy of community-acquired bacterial pneumonia. International Journal of Antimicrobial Agents, 36(3): 197-204
Lin, W., Lo, W., Chou, C., Chen, Y., Tsai, S., Chu, M., Wang, C. (2006) Antimicrobial resistance patterns and serotype distribution of invasive Streptococcus pneumoniae isolates from children in Taiwan from 1999 to 2004. Diagnostic Microbiology and Infectious Disease, 56(2): 189-196
Linares, J., Ardanuy, C., Pallares, R., Fenoll, A. (2010) Changes in antimicrobial resistance, serotypes and genotypes in Streptococcus pneumoniae over a 30-year period. Clin Microbiol Infect, 16: 402-10
Lismond, A., Carbonnelle, S., Verhaegen, J., Schatt, P., de Bel, A., Jordens, P., Jacobs, F., Dediste, A., Verschuren, F., Huang, T. (2012) Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically confirmed diagnosis of community-acquired pneumonia in Belgium. International Journal of Antimicrobial Agents, 39(3): 208-216
Ma, X., Zhao, R., Ma, Z., Yao, K., Yu, S., Zheng, Y., Yang, Y. (2013) Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Isolates Causing Invasive Diseases from Shenzhen Children’s Hospital. PLoS ONE, 8(6): e67507
Mijac, V., Opavski, N., Markovic, M., Gajic, I., Vasiljevic, Z., Sipetic, T., i dr. (2015) Trends in macrolide resistance of respiratory tract pathogens in the paediatric population in Serbia from 2004 to 2009. Epidemiol Infect, 143: 648-52
Ovetchkine, P., Rieder, M.J. (2013) Azithromycin use in paediatrics: A practical overview. Paediatr Child Health, 18: 311-3
Reinert, R.R., Reinert, S., van der Linden, M., Cil, M.Y., Al-Lahham, A., Appelbaum, P. (2005) Antimicrobial Susceptibility of Streptococcus pneumoniae in Eight European Countries from 2001 to 2003. Antimicrobial Agents and Chemotherapy, 49(7): 2903-2913
Reynolds, C.A., Finkelstein, J.A., Ray, G., Moore, M.R., Huang, S.S. (2014) Attributable healthcare utilization and cost of pneumonia due to drug-resistant streptococcus pneumonia: a cost analysis. Antimicrobial Resistance and Infection Control, 3(1): 16
Yokota, S., Sato, K., Fujii, N., Sato, K., Yoshida, S., Akizawa, H., Hayashi, T., Matsuda, K., Kuwahara, O., Habadera, S. (2004) Macrolide-resistant Streptococcus pneumoniae clinical isolates that occur in Hokkaido prefecture, Japan. Journal of Infection and Chemotherapy, 10(5): 284-287