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2016, vol. 144, br. 9-10, str. 490-496
Faktori rizika za razvoj bolničkih infekcija urinarnog trakta uzrokovanih multirezistentnim mikroorganizmima
aKlinički centar Kragujevac
bUniverzitet u Kragujevcu, Medicinski fakultet + Klinički centar Kragujevac, Služba za kliničku farmakologiju
cKlinički centar Kragujevac, Klinika za infektivne bolesti

e-adresamarkof@medf.kg.ac.rs
Projekat:
Farmakološka analiza efekata biološki aktivnih supstanci na izolovane glatke mišiće gastrointestinalnog i urogenitalnog trakta čoveka (MPNTR - 175007)
Projekat Ministarstva nauke Crne Gore, br.404

Ključne reči: infekcije urinarnog trakta; bolničke infekcije; multipla rezistencija na antibiotike; faktori rizika
Sažetak
Uvod Bolničke infekcije urinarnog trakta čine i do 40% svih bolničkih infekcija i značajno doprinose bolničkom morbiditetu, mortalitetu i rastu ukupnih troškova lečenja. Cilj rada Cilj našeg istraživanja bio je da se utvrde potencijalni faktori rizika za razvoj bolničkih infekcija urinarnog trakta uzrokovanih multirezistentnim (MR) patogenima. Metode rada Sprovedena je klinička studija tipa slučaj kontrola u periodu od pet godina u zdravstvenoj ustanovi tercijarnog nivoa zdravstvene delatnosti. Grupu slučajeva činili su bolesnici sa bolničkim infekcijama urinarnog trakta prouzrokovanim MR bakterijama, dok su kontrolnu grupu činili pacijenti sa bolničkim infekcijama urinarnog trakta uzrokovanim bakterijama koje nisu pripadale prethodno navedenoj grupi uzročnika infekcija. Rezultati Ukupno je bilo 562 (62,6%) bolesnika sa verifikovanim MR izolatima, odnosno 336 (37,4%) pacijenata sa izolatima koji nisu pripadali MR grupi patogena. Identifikovana su četiri značajna prediktora koja mogu doprineti razvoju bolničkih infekcija urinarnog trakta prouzrokovanih multirezistentnim patogenima: hospitalizacija pre plasiranja urinarnog katetera duža od osam dana (ORadjusted = 2,763; 95% CI = 1,352-5,647, p = 0,005), dužina hospitalizacija od 15 i više dana (ORadjusted = 2,144; 95% CI = 1,547-2,970, p < 0,001), prethodni boravak na drugom odeljenju (intenzivna nega, druga odeljenja ili bolnice) (ORadjusted = 2,147; 95% CI = 1,585-2,908, p < 0,001) i karcinomi različitih lokalizacija (ORadjusted = 2,313; 95% CI = 1,255-4,262; p = 0,007). Zaključak Pravovremeno (rano) uklanjanje urinarnog katetera i smanjenje vremena provedenog u bolnici ili u intenzivnoj nezi mogli bi značajno da doprinesu redukciji stope bolničkih infekcija urinarnog trakta prouzrokovanih multirezistentnim patogenima.
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O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.2298/sarh1610490d
objavljen u SCIndeksu: 26.11.2016.